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This detailed volume explores the application of multiplex
biomarker methods in the critical area of COVID-19 research through
state-of-the-art technologies in the fields of genomics,
proteomics, transcriptomics, metabolomics, and imaging. The book
features a series of protocols from labs across the globe employing
multiplex molecular approaches, which can be applied to accelerate
progress in the research of SARS-CoV-2 and other infectious
illnesses. Written for the highly successful Methods in Molecular
Biology series, chapters include introductions to their respective
topics, lists of the necessary materials and reagents,
step-by-step, readily reproducible laboratory protocols, and tips
on troubleshooting and avoiding known pitfalls.Â
Authoritative and essential, Multiplex Biomarker Techniques:
Methods and Applications for COVID-19 Disease Diagnosis and Risk
Stratification serves as a vital resource for researchers in the
areas of virology, metabolic diseases, respiratory disorders, as
well as to clinical scientists, physicians, pharmacologists, and
the healthcare services.
The novel coronavirus 2019 (COVID-19) has caused a serious global
pandemic in just eight months. Nearly every country and territory
in the world has been affected by the virus. The virulence and
infection rate of the virus are profound, and has required extreme
social distancing measures across the globe in order to prevent
overwhelming the healthcare services and hospitals. COVID-19
appears to have the greatest effects on elderly individuals and
those who have co-morbid diseases, such as heart disease, asthma,
and diabetes. As the peak begins to slow in many countries, the
death rates remain high amidst justified fears of a second wave. A
rapid worldwide mobilization has begun to identify effective
treatments and develop vaccines. This new volume will increase
readers' understanding of the ongoing COVID-19 pandemic through a
series of chapters that address these concerns. Leading experts
will discuss the effects of the virus in cases of co-morbidities,
new treatment approaches, mental health aspects of the pandemic,
and convey the results of survey studies. The book will be an
excellent resource for researchers studying virology, metabolic
diseases, respiratory disorders, and clinical scientists,
physicians, drug companies, and healthcare services and workers.
Using both epidemiological and model organism approaches, we have
gained new insights into the physiological and molecular aspects of
aging, which has led to significant advancements in potential
anti-aging strategies. Reviews on Biomarker Studies in Aging and
Anti-Aging Research presents a series of reviews in various aspects
of aging and age-related disease research along with several
methods which have shown progress as potential anti-aging
approaches. The book is aimed at researchers in the areas of aging
and chronic disease, as well as to clinical scientists, physicians
and major drug companies. It provides important information on
disease mechanisms, and each chapter is presented in the context of
the aging process, specific chronic diseases or different
therapeutic areas.
This detailed book arrives as there is an increasing need for
multiplex biomarker readouts for improved clinical management and
to support the development of new drugs by pharmaceutical
companies, due to continuous technical developments and new
insights into the high complexity of many diseases. Chapters
explore the basic technology platforms being applied in the fields
of genomics, proteomics, transcriptomics, metabolomics, and
imaging, which are currently the methods of choice in multiplex
biomarker research. The book also describes the chief medical areas
in which the greatest progress has been made and highlight areas
where further resources are required. Written for the highly
successful Methods in Molecular Biology series, methodology
chapters include introductions to their respective topics, lists of
the necessary materials and reagents, step-by-step, readily
reproducible laboratory protocols, and tips on troubleshooting and
avoiding known pitfalls. Multiplex Biomarker Techniques: Methods
and Applications serves as an ideal resource for a wide variety of
researchers interested in these vital multiplex techniques.
Employing accessible language throughout, this book covers the
history of psychiatric research, the current state-of-the art in
psychiatric practice, the physiological systems affected by
psychiatric illnesses, the whole-body nature of these diseases and
the impact that this aspect has on emerging biomarker discoveries.
Further, it provides descriptions of the major specific psychiatric
disorders and the special challenges regarding the diagnosis and
treatment of each. The book concludes with insights into the latest
developments in hand-held biomarker test devices, which can provide
diagnostic information in less than 15 minutes in point-of-care
settings. This book investigates the emerging use of biomarkers in
the study of psychiatric diseases, a topic of considerable
importance for a broad range of people including researchers,
clinicians, psychiatrists, university students and even those whose
lives are affected in some way by a psychiatric illness. The last
category is hardly trivial, since a staggering one in three people
worldwide show the criteria for at least one psychiatric disorder
at some point in their lifetime.
This volume contains several reviews in the field as well as the
step-by-step use of targeted and global approaches within the areas
of genomics, epigenetics, proteomics, transcriptomics and
metabolomics which aim to address this dilemma and to help pinpoint
new treatment strategies. Chapters detail the generation of several
models and methods for assessing health and provide researchers
potential approaches for reversing or minimizing effects of
disease. In addition, important information on disease mechanisms
is provided, as each method is described in the context of a
specific disease or therapeutic area. Written in the highly
successful Methods in Molecular Biology series format, the chapters
include introductions to their respective topics, lists of the
necessary materials and reagents, step-by-step, readily
reproducible laboratory protocols, and tips on troubleshooting and
avoiding known pitfalls. Authoritative and practical,
Investigations of Early Nutrition Effects on Long-Term Health:
Methods and Applications aim is to provide insights into the latest
ideas and technologies .enabling progress in this field.
Employing accessible language throughout, this book covers the
history of psychiatric research, the current state-of-the art in
psychiatric practice, the physiological systems affected by
psychiatric illnesses, the whole-body nature of these diseases and
the impact that this aspect has on emerging biomarker discoveries.
Further, it provides descriptions of the major specific psychiatric
disorders and the special challenges regarding the diagnosis and
treatment of each. The book concludes with insights into the latest
developments in hand-held biomarker test devices, which can provide
diagnostic information in less than 15 minutes in point-of-care
settings. This book investigates the emerging use of biomarkers in
the study of psychiatric diseases, a topic of considerable
importance for a broad range of people including researchers,
clinicians, psychiatrists, university students and even those whose
lives are affected in some way by a psychiatric illness. The last
category is hardly trivial, since a staggering one in three people
worldwide show the criteria for at least one psychiatric disorder
at some point in their lifetime.
This detailed book arrives as there is an increasing need for
multiplex biomarker readouts for improved clinical management and
to support the development of new drugs by pharmaceutical
companies, due to continuous technical developments and new
insights into the high complexity of many diseases. Chapters
explore the basic technology platforms being applied in the fields
of genomics, proteomics, transcriptomics, metabolomics, and
imaging, which are currently the methods of choice in multiplex
biomarker research. The book also describes the chief medical areas
in which the greatest progress has been made and highlight areas
where further resources are required. Written for the highly
successful Methods in Molecular Biology series, methodology
chapters include introductions to their respective topics, lists of
the necessary materials and reagents, step-by-step, readily
reproducible laboratory protocols, and tips on troubleshooting and
avoiding known pitfalls. Multiplex Biomarker Techniques: Methods
and Applications serves as an ideal resource for a wide variety of
researchers interested in these vital multiplex techniques.
The COVID-19 pandemic caused by the SARS-CoV-2 virus has affected
nearly every country and territory in the world. Although worldwide
vaccination efforts have reduced the risk of serious disease
outcomes, disparities in distribution have led to multiple waves of
SARS-CoV-2 outbreaks and the emergence of variants of concern, some
of which have enhanced infectivity and ability to evade existing
vaccines. Hence there is an increasing interest in understanding
the evolution of viruses like SARS-CoV-2, as well as improving our
capacity to effectively current and manage future pandemics. This
new volume reviews the most effective omic techniques for
increasing our understanding of COVID-19, to improve diagnostics,
prognostics, and genomic surveillance, and to facilitate
development of effective treatments and vaccines. Chapters are
written by an international team of experts and explore methods in
the areas of genomics, transcriptomics, proteomics, and
metabolomics. Techniques used to assess physiological function at
the molecular level and artificial intelligence approaches used for
more effective validation and translation of biomarker candidates
into clinical use are also discussed. This book is an excellent
resource for researchers studying biomarkers, virology, metabolic
diseases, and infectious diseases, as well as clinical scientists,
physicians, drug company scientists, and healthcare workers.
This detailed book explores protocols with the aim of testing
aerobic exercise, resistance training, special diets, additives and
natural products, which have led to new insights into the
physiological and molecular aspects of health and disease. Many of
these approaches have contributed to significant improvements in
disease areas such as cardiovascular disease, cognitive
dysfunction, diabetes, frailty, gliobastoma, metabolic syndrome,
obesity, oxidative stress, and various cancers. This collection
also provides important information on disease mechanisms and novel
drug targets as each protocol is presented in the context of
specific chronic diseases or different therapeutic areas. Written
for the highly successful Methods in Molecular Biology series,
chapters include introductions to their respective topics, lists of
the necessary materials, step-by-step, readily reproducible
protocols, and tips on troubleshooting and avoiding known pitfalls.
Authoritative and reflective of research from all around the globe,
Physical Exercise and Natural and Synthetic Products in Health and
Disease serves as an ideal guide for researchers in the areas of
chronic disease, exercise, and nutrition, as well as to clinical
scientists, physicians, and pharmacologists as it gives insights
into possibilities for the development of novel therapeutics and
the means of monitoring therapeutic response through the
measurement of molecular and physiometric biomarkers.
This detailed volume explores the application of multiplex
biomarker methods in the critical area of COVID-19 research through
state-of-the-art technologies in the fields of genomics,
proteomics, transcriptomics, metabolomics, and imaging. The book
features a series of protocols from labs across the globe employing
multiplex molecular approaches, which can be applied to accelerate
progress in the research of SARS-CoV-2 and other infectious
illnesses. Written for the highly successful Methods in Molecular
Biology series, chapters include introductions to their respective
topics, lists of the necessary materials and reagents,
step-by-step, readily reproducible laboratory protocols, and tips
on troubleshooting and avoiding known pitfalls. Authoritative and
essential, Multiplex Biomarker Techniques: Methods and Applications
for COVID-19 Disease Diagnosis and Risk Stratification serves as a
vital resource for researchers in the areas of virology, metabolic
diseases, respiratory disorders, as well as to clinical scientists,
physicians, pharmacologists, and the healthcare services.
This detailed book explores protocols with the aim of testing
aerobic exercise, resistance training, special diets, additives and
natural products, which have led to new insights into the
physiological and molecular aspects of health and disease. Many of
these approaches have contributed to significant improvements in
disease areas such as cardiovascular disease, cognitive
dysfunction, diabetes, frailty, gliobastoma, metabolic syndrome,
obesity, oxidative stress, and various cancers. This collection
also provides important information on disease mechanisms and novel
drug targets as each protocol is presented in the context of
specific chronic diseases or different therapeutic areas. Written
for the highly successful Methods in Molecular Biology series,
chapters include introductions to their respective topics, lists of
the necessary materials, step-by-step, readily reproducible
protocols, and tips on troubleshooting and avoiding known pitfalls.
Authoritative and reflective of research from all around the globe,
Physical Exercise and Natural and Synthetic Products in Health and
Disease serves as an ideal guide for researchers in the areas of
chronic disease, exercise, and nutrition, as well as to clinical
scientists, physicians, and pharmacologists as it gives insights
into possibilities for the development of novel therapeutics and
the means of monitoring therapeutic response through the
measurement of molecular and physiometric biomarkers.
The Middle East is known as the cradle of civilization. It was the
crossroads of ancient empires and the birthplace of major world
religions. Today it is the center of many world issues due to its
economic, religious and political importance. Although it has
lagged behind many other regions of the world in medicinal
research, this has increased dramatically in recent years with
increasing numbers of relevant publications and the country of Iran
has spearheaded this progress. Much of the research has focused on
increasing our understanding of the aging process and attempting to
identify biomarkers and natural products to improve the human
healthspan. This book provides a comprehensive overview of the
research conducted in the Middle East on the health benefits of
curcumin, a phytochemical derived from the famous spice turmeric.
Hundreds of studies have now been published describing the health
benefits of this spice. The importance of this research is
exemplified by poor data regarding health and longevity as only
0.08% of the population in Iran consists of individuals over 90
years of age. This is approximately 10 times lower than the
percentage of this same age group in the United Kingdom and the
United States of America and almost 20 times lower than that in
Japan. This book presents a series of reviews and meta-studies
describing research which has resulted in identification potential
new biomarkers and drug targets for age-related disorders. All of
the studies have focussed on the testing of curcumin and related
products, which have already shown some promising leads in
age-related conditions such as heart-disease, diabetes, cognitive
impairment and cancer. The authors in this series come from
different centers and cities of Iran, including Mashhad, Tehran,
Isfahan, Ahvaz, Birjand, Quchan and Yazd, and many of the chapters
feature collaborations with other countries of the Middle East and
throughout the world, including Brazil, Italy, Mexico, Oman,
Poland, Switzerland, the United Kingdom and the United States of
America. This underscores the emergence of the Middle East into
this arena of research. The book will be of high interest to
scientific and clinical researchers in the subject of aging and
age-related disease, and to physicians and pharmaceutical company
scientists since it gives insights into the latest strategies,
biomarkers and targets involved in the mechanism of action of
curcumin to promote healthy aging. It will also provide important
information on disease mechanisms related to age-related disorders,
as each chapter will be presented in the context of specific
chronic diseases.
The novel coronavirus 2019 (COVID-19) has caused a serious global
pandemic in just one year. Nearly every country and territory in
the world has been affected by the virus. The virulence and
infection rate of the virus are profound, and has required extreme
social distancing measures across the globe in order to prevent
overwhelming the healthcare services and hospitals. COVID-19
appears to have the greatest effects on elderly individuals and
those who have co-morbid diseases, such as diabetes and obesity. As
the cases and death rate remain high, there are justified fears of
this virus remaining for several months or years to come. To
address this, a rapid and unprecedented worldwide mobilization
effort has begun to identify effective treatments and develop
vaccines. As these begin to be deployed and administered across the
globe, many now feel the virus will be brought under control and
lives will eventually return to normal. This new volume will
increase readers' understanding of the ongoing COVID-19 pandemic
through a series of chapters that address these concerns. Leading
experts will discuss new treatment approaches, vaccine development,
mental health aspects of the pandemic, and convey the results of
survey studies. The book will be an excellent resource for
researchers studying virology, metabolic diseases, respiratory
disorders, and clinical scientists, physicians, drug companies, and
healthcare services and workers.
This book includes a series of reviews on general aspects of
biomarker use in the study of psychiatric and neurodegenerative
diseases and the development of medications involved in their
treatment. It describes the pros and cons of the various approaches
and covers the successes and failures in this research field. It is
only by a thorough understanding of the shortcomings that progress
can be made. The overall goal is to facilitate the understanding
and treatment of these disorders, by providing a viable mechanism
of catching up with other areas of modern medicine, such as
diabetes and heart disease. Finally, it is anticipated that the
development and application of valid biomarker tests and the
leveraging of novel drug targets will help the fields of psychiatry
on neurodegenerative disorders move into the area of personalized
medicine where the right patients can receive the right medication
at the right time for the best possible outcome.
Aging is an inevitable part of life and is becoming a worldwide
social, economic and health problem. This is mainly due to the fact
that the increasing proportion of individuals in the advanced age
category have a higher probability of developing age-related
disorders, such as type II diabetes mellitus, cardiovascular
disorders, sarcopenia, and neurodegenerative conditions. New
therapeutic approaches are still needed to decrease or slow the
effects of such diseases. Advances in -omic technologies, such as
genomics, transcriptomics, proteomics and metabolomics, have
significantly advanced our understanding of disease in multiple
medical areas, as the analysis of multiple molecular networks has
simultaneously provided a more integrated view of disease pathways.
It is hoped that emerging hits from these analyses might be
prioritized for further screening as potential novel drug targets
for increasing the human healthspan in line with the lifespan. In
turn, this will lead to new therapeutic strategies as well as drug
development projects by the pharmaceutical industry. This book
presents a series of reviews describing studies that have resulted
in identification of new potential drug targets for age-related
disorders. Much of this information has come from -omic comparisons
of healthy and disease states or from testing the effects of new
therapeutic approaches. Authored by experts from around the globe,
each chapter is presented in the context of specific chronic
diseases or therapeutic strategies. This book is designed for
researchers in the areas of aging and chronic disease, as well as
clinical scientists, physicians and stakeholders in major drug
companies.
Aging is an inevitable part of life, and is becoming a worldwide
social, economic and health problem due to the fact that an
increasing proportion of individuals in the advanced age category
have a higher probability of developing age-related disorders. New
therapeutic approaches are still in need to decrease or slow the
effects of such diseases in this aging society. Advances in 'omic
technologies such as genomics, transcriptomics, proteomics and
metabolomics have significantly advanced our understanding of
diseases in multiple medical areas. It is hoped that emerging hits
from these analyses might be prioritized for further screening as
potential novel drug targets for increasing the human healthspan in
line with the lifespan, which will in turn lead to new therapeutic
strategies and drug development projects by the pharmaceutical
industry. This new book presents a series of reviews describing
studies which have resulted in the identification of potential new
drug targets for age-related disorders. Much of this information
has come from 'omic comparisons of healthy and disease states or
from testing the effects of potential new therapeutic approaches.
Each chapter will be presented in the context of specific chronic
diseases or different therapeutic strategies, providing important
information on disease mechanisms related to the aging process.
This book will be of interest to researchers in the areas of aging
and chronic disease, as well as clinical scientists, physicians,
and major drug companies. With contributors from Australia, Brazil,
Canada, France, Germany, India, Iran, Iraq, South Africa, South
Korea, Thailand, Ukraine, United Kingdom, United States of America,
Uruguay and Vietnam, this is a timely follow up to Guest's previous
book Reviews on New Drug Targets in Age-Related Disorders.
Using both epidemiological and model organism approaches, we have
gained new insights into the physiological and molecular aspects of
aging, which has led to significant advancements in potential
anti-aging strategies. Reviews on Biomarker Studies in Aging and
Anti-Aging Research presents a series of reviews in various aspects
of aging and age-related disease research along with several
methods which have shown progress as potential anti-aging
approaches. The book is aimed at researchers in the areas of aging
and chronic disease, as well as to clinical scientists, physicians
and major drug companies. It provides important information on
disease mechanisms, and each chapter is presented in the context of
the aging process, specific chronic diseases or different
therapeutic areas.
The book recognizes that throughout the scientific, medical, and
economic communities, new tests incorporating biomarkers are needed
to improve the diagnosis of patients suffering from metabolic
disorders. The early identification of those at risk of developing
obesity will help to place these individuals on the best treatment
course as early as possible for improved treatment outcomes. This
will also help to cut costs incurred by the healthcare services.
For all of this to occur, new research efforts are needed to
identify novel biomarkers that can be used to predict the disease
in the presymptomatic stage, for disease monitoring and for
prediction of treatment response. It is also possible that new drug
targets can be identified using these approaches which, in turn,
can lead to the development of new treatment approaches. This
volume also includes a series of reviews on biomarker discovery and
usage in the study of diseases marked by perturbations in
metabolism. It will describe the pros and cons of the various
approaches and cover the successes and failures in this important
research field.
Aging is an inevitable part of life and is becoming a worldwide
social, economic and health problem. This is mainly due to the fact
that the increasing proportion of individuals in the advanced age
category have a higher probability of developing age-related
disorders, such as type II diabetes mellitus, cardiovascular
disorders, sarcopenia, and neurodegenerative conditions. New
therapeutic approaches are still needed to decrease or slow the
effects of such diseases. Advances in -omic technologies, such as
genomics, transcriptomics, proteomics and metabolomics, have
significantly advanced our understanding of disease in multiple
medical areas, as the analysis of multiple molecular networks has
simultaneously provided a more integrated view of disease pathways.
It is hoped that emerging hits from these analyses might be
prioritized for further screening as potential novel drug targets
for increasing the human healthspan in line with the lifespan. In
turn, this will lead to new therapeutic strategies as well as drug
development projects by the pharmaceutical industry. This book
presents a series of reviews describing studies that have resulted
in identification of new potential drug targets for age-related
disorders. Much of this information has come from -omic comparisons
of healthy and disease states or from testing the effects of new
therapeutic approaches. Authored by experts from around the globe,
each chapter is presented in the context of specific chronic
diseases or therapeutic strategies. This book is designed for
researchers in the areas of aging and chronic disease, as well as
clinical scientists, physicians and stakeholders in major drug
companies.
The book recognizes that throughout the scientific, medical, and
economic communities, new tests incorporating biomarkers are needed
to improve the diagnosis of patients suffering from metabolic
disorders. The early identification of those at risk of developing
obesity will help to place these individuals on the best treatment
course as early as possible for improved treatment outcomes. This
will also help to cut costs incurred by the healthcare services.
For all of this to occur, new research efforts are needed to
identify novel biomarkers that can be used to predict the disease
in the presymptomatic stage, for disease monitoring and for
prediction of treatment response. It is also possible that new drug
targets can be identified using these approaches which, in turn,
can lead to the development of new treatment approaches. This
volume also includes a series of reviews on biomarker discovery and
usage in the study of diseases marked by perturbations in
metabolism. It will describe the pros and cons of the various
approaches and cover the successes and failures in this important
research field.
Due to continuous technical developments and new insights into the
high complexity of neurological diseases, there is an increasing
need for the application of proteomic technologies which can yield
potential biomarker readouts for improved clinical management as
well as for the development of new drugs by struggling
pharmaceutical companies. This book describes the step-by-step use
of proteomic methods such as two-dimensional gel electrophoresis,
multiplex immunoassay, liquid chromatography mass spectrometry
(LC-MS) and selective reaction monitoring MS, to increase our
understanding of these diseases, with the ultimate aim of improving
patient care. The volume will be of high interest to clinical
scientists, physicians and pharmaceutical company scientists as it
gives insights into the latest technologies enabling the revolution
of personalized medicine. It is of direct interest to both
technical and bench biomarker scientists as it gives step by step
instructions on how to carry out each of the protocols. It is also
of interest to researchers as each technique will be presented in
the context of a specific neurological disorder, including
Alzheimer's disease, multiple sclerosis, autism spectrum disorders,
schizophrenia, major depressive disorder and bipolar disorder.
Finally, it will also highlight the future research efforts in this
field, which are endeavoring to convert proteomic platforms to the
form of hand held devices which can be used in a point of care
setting and return diagnostic results within the timeframe of a
visit to the general practitioner.
Due to continuous technical developments and new insights into the
high complexity of neurological diseases, there is an increasing
need for the application of proteomic technologies which can yield
potential biomarker readouts for improved clinical management as
well as for the development of new drugs by struggling
pharmaceutical companies. This book describes the step-by-step use
of proteomic methods such as two-dimensional gel electrophoresis,
multiplex immunoassay, liquid chromatography mass spectrometry
(LC-MS) and selective reaction monitoring MS, to increase our
understanding of these diseases, with the ultimate aim of improving
patient care. The volume will be of high interest to clinical
scientists, physicians and pharmaceutical company scientists as it
gives insights into the latest technologies enabling the revolution
of personalized medicine. It is of direct interest to both
technical and bench biomarker scientists as it gives step by step
instructions on how to carry out each of the protocols. It is also
of interest to researchers as each technique will be presented in
the context of a specific neurological disorder, including
Alzheimer's disease, multiple sclerosis, autism spectrum disorders,
schizophrenia, major depressive disorder and bipolar disorder.
Finally, it will also highlight the future research efforts in this
field, which are endeavoring to convert proteomic platforms to the
form of hand held devices which can be used in a point of care
setting and return diagnostic results within the timeframe of a
visit to the general practitioner.
This volume details reviews and protocols on the development and
analysis of both cellular and animal-based pre-clinical models in a
number of medical areas, including metabolic disorders, longevity,
cancer, heart disease and psychiatric disorders. Written in the
highly successful Methods in Molecular Biology series format,
chapters include introductions to their respective topics, lists of
the necessary materials and reagents, step-by-step, readily
reproducible laboratory protocols, and tips on troubleshooting and
avoiding known pitfalls. Authoritative and cutting-edge,
Pre-Clinical Models: Techniques and Protocols aims to provide
methods that describe the context of specific disease or
therapeutic areas.
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