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Reviews on New Drug Targets in Age-Related Disorders (Paperback, 1st ed. 2020)
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Reviews on New Drug Targets in Age-Related Disorders (Paperback, 1st ed. 2020)
Series: Advances in Experimental Medicine and Biology, 1260
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Aging is an inevitable part of life and is becoming a worldwide
social, economic and health problem. This is mainly due to the fact
that the increasing proportion of individuals in the advanced age
category have a higher probability of developing age-related
disorders, such as type II diabetes mellitus, cardiovascular
disorders, sarcopenia, and neurodegenerative conditions. New
therapeutic approaches are still needed to decrease or slow the
effects of such diseases. Advances in -omic technologies, such as
genomics, transcriptomics, proteomics and metabolomics, have
significantly advanced our understanding of disease in multiple
medical areas, as the analysis of multiple molecular networks has
simultaneously provided a more integrated view of disease pathways.
It is hoped that emerging hits from these analyses might be
prioritized for further screening as potential novel drug targets
for increasing the human healthspan in line with the lifespan. In
turn, this will lead to new therapeutic strategies as well as drug
development projects by the pharmaceutical industry. This book
presents a series of reviews describing studies that have resulted
in identification of new potential drug targets for age-related
disorders. Much of this information has come from -omic comparisons
of healthy and disease states or from testing the effects of new
therapeutic approaches. Authored by experts from around the globe,
each chapter is presented in the context of specific chronic
diseases or therapeutic strategies. This book is designed for
researchers in the areas of aging and chronic disease, as well as
clinical scientists, physicians and stakeholders in major drug
companies.
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