This volume provides detailed coverage of modern methods for molecular analysis of enzymes and enzyme systems that function in the maintenance of genome integrity. Coverage areas include base excision repair, nucleotide excision repair, translesion DNA polymerases, mismatch repair, genetic recombination, and double strand break repair.
*A laboratory standard for more than 40 years
*Over 400 volumes strong
*Also available on ScienceDirect
*Part A of a 2-part series

This volume emphasizes the intracellular consequences of DNA damage, describing procedures for analysis of checkpoint responses, DNA repair in vivo, replication fork encounter of DNA damage, as well as biological methods for analysis of mutation production and chromosome rearrangements. It also describes molecular methods for analysis of a number of genome maintenance activities including DNA ligases, helicases, and single-strand binding proteins.
*Part B of a 2-part series
*Addresses DNA maintenance enzymes
*Discusses damage signaling
*Presents "In vivo" analysis of DNA repair
*Covers mutation and chromosome rearrangements