In many parts of the world, there is a crisis of mobility. The choices we have made over the past 200 years on modes and technologies of transport have brought us unprecedented global interaction and in many respects increased personal freedom. However, all this mobility has come at a cost to society, to the economy and to the environment. Mobility is in crisis, but few seem aware of the full extent of it. Though most people will be aware of congestion, accidents (although this aspect is often overlooked), parking restrictions or fuel prices, few will have considered the effects of the dramatic increase in mobility expected in China, India and elsewhere. Nor do many people in their daily lives consider the impact of climate change on our environment and the contribution our cars make to it. It is often thought that technology alone can solve this problem. For some observers, salvation could be achieved by means of hydrogen fuel cells, by hybrid cars, or by increased fuel efficiency, or even by telematics to reduce congestion. This book shows that "technology" may well not be enough in itself and that for a genuinely sustainable transport future far more radical change - affecting many aspects of society - is needed. It is likely, for example, that new business models are needed, as well as users and consumers adopting new forms of behaviour. Disruptive technological innovation may well contribute, but needs to be induced by a combination of market forces and government regulation. Many studies touch on transport and mobility issues and more mainstream books aimed at challenging the dominance of automobility are common, yet works dealing with the longer-term strategic, theoretical and broader conceptual issues needed to inform the move towards more sustainable transport are rare. Yet policy-makers, practitioners, as well as many sections of academia, acknowledge a need for guidance on new thinking on sustainable mobility. This book brings together a range of views representing both leading-edge thinking and best practice in the mobility sector. The individual expert contributions form the basis for framing a broader vision of future mobility and proposed transition trajectories towards that future. Much of the effort reflected in the chapters in this book is concerned with going beyond the "technofix" of new cars, to confront the more difficult challenges of institutional, cultural and social change within and beyond the industry that have to be resolved in the transition towards sustainability. It therefore seeks to break through the conventional boundary between engineering and the social sciences, and the contributors come from both sides of this traditional but unnecessary divide, combining economists, engineers, geographers, designers and others. The work is based on the sustainable mobility stream in the 2003 International Greening of Industry Network conference in San Francisco. This event brought together experts from industry and government, and the book combines some of the papers presented there, developed and updated into full chapters, with a number of additional chapters to capture some of the themes that emerged from the conference. The central problem addressed in this book is the private car: how to power it, how to build it and how to deliver it to customers in a more sustainable future. It starts with ideas of radical innovation in the propulsion system of the car, notably the hydrogen fuel cell. In one section, the book examines business models that could be used to deliver automobility in a more sustainable manner. This section looks at how the car is made and used, and looks beyond it by examining how we could change those aspects in our quest for sustainable mobility. The book then considers a number of recently introduced vehicles and alternative vehicle concepts within the context of a dominant existing paradigm. These vary from a minimalist single-seat commuter to a powertrain exchange concept that could breathe new life into the electric vehicle. A number of chapters then report on current practice and experience in the initial moves toward more sustainable automobility. Finally, more visionary views are presented to look at what conclusions we can draw from the strands discussed and suggest possible future scenarios: where do we go from here? When thinking about the car, it is often not appreciated to what extent our modern culture is integrated with the car and its systems: we have literally built our world around the car in its current form, and this inevitably shapes the scope for constructing sustainable mobility. We therefore need to tackle any change to the current automobility paradigm on a very broad front and we need to be prepared for the possibly dramatic social and economic changes we may bring about by changing just some elements. The Business of Sustainable Mobility will be essential reading for academics, practitioners, policy-makers and others interested in the latest thinking on sustainable mobility.

In 1966, the first Germinal Centre Conference was held in Bern, Switzerland, as a result of an initiative from C. C. Longdon of Oak Ridge, Tennessee and H. Cottier of Bern. Fifteen years later, in June of 1981, the 7th conference in this series was held in Groningen, the Netherlands. At this "International Conference on Lymphatic Tissues and Germinal Centers in Immune Reactions," instead of focusing on germinal centres only, the intricate relationships between various constituents of the lympho-myeloid complex consti tuted the theme of the meeting. As Yoffee stated in 1966, "Perhaps we should consider not only the germinal centre itself but the surrounding tissue as well. " Over the years, these conferences have brought together a small but dedicated group of scientists, sharing (1) a fundamental interest in the physiology of the lymphoid system proper, and (2) the recognition that, only in the in vivo situation can the final answers be obtained, however ingeniously in vitro experiments may mimic reality. In 1966, the conference lasted three days and included 57 contributions "which were discussed at length. " The present conference accomodated 62 free papers and 64 poster presentations as well as some 24 additional abstracts selected from more than 200 submissions. Prominent among the selection criteria was the adage "in vivo veritas. " This volume represents the presentations from the 1981 Germinal Centre Conference."

These Proceedings contain the contributions of the participants of the Second International Symposium on Dendritic Cells that was held from the 1st to 25th of June 1992 in Amsterdam, the Netherlands. The First International Symposium on Dendritic Cells was organized as a Satellite symposium at the occasion of the 30th anniversary of the Japanese Reticuloendothelial Society by Dr. Y. Imai in Yamagata (Japan), in 1990. It was entitled "Dendritic Cells in Lymphoid Tissues," and focused primarily on the Interdigitating Cells (IDC), Epidermal Langerhans cells (LC) and Follicular Dendritic Cells (FDC) , from the point of view of human pathology. However, the concept of Dendritic Cell System, comprising the bone marrow derived IDC and LC but not the FDC, was based on animal experiments and mainly on in vitro experiments on isolated cells. In a report from the Reticuloendothelial Society Committee on Nomenclature in 1982, Tew, Thorbecke and Steinman had already characterized these different types of DC, but the gap between in vivo and in vitro function remained. In Amsterdam, the Symposium focused on the Role of Dendritic Cells in Fundamental and Clinical Immunology. First, recent developments in molecular biology of antigen presentation and cell biological aspects of signal transduction were discussed, in relation to the potential of DC to stimulate lymphocytes and to trigger their in vitro differentiation.