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Dendritic Cells in Fundamental and Clinical Immunology (Paperback, Softcover reprint of the original 1st ed. 1993)
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Dendritic Cells in Fundamental and Clinical Immunology (Paperback, Softcover reprint of the original 1st ed. 1993)
Series: Advances in Experimental Medicine and Biology, 329
Expected to ship within 10 - 15 working days
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These Proceedings contain the contributions of the participants of
the Second International Symposium on Dendritic Cells that was held
from the 1st to 25th of June 1992 in Amsterdam, the Netherlands.
The First International Symposium on Dendritic Cells was organized
as a Satellite symposium at the occasion of the 30th anniversary of
the Japanese Reticuloendothelial Society by Dr. Y. Imai in Yamagata
(Japan), in 1990. It was entitled "Dendritic Cells in Lymphoid
Tissues," and focused primarily on the Interdigitating Cells (IDC),
Epidermal Langerhans cells (LC) and Follicular Dendritic Cells
(FDC) , from the point of view of human pathology. However, the
concept of Dendritic Cell System, comprising the bone marrow
derived IDC and LC but not the FDC, was based on animal experiments
and mainly on in vitro experiments on isolated cells. In a report
from the Reticuloendothelial Society Committee on Nomenclature in
1982, Tew, Thorbecke and Steinman had already characterized these
different types of DC, but the gap between in vivo and in vitro
function remained. In Amsterdam, the Symposium focused on the Role
of Dendritic Cells in Fundamental and Clinical Immunology. First,
recent developments in molecular biology of antigen presentation
and cell biological aspects of signal transduction were discussed,
in relation to the potential of DC to stimulate lymphocytes and to
trigger their in vitro differentiation.
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