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In this volume a distinguished group of internationally renowned
clinicians and basic researchers discuss the present state of
knowledge of the etiologyand pathogenesis of Dupuytren's
contracture, a disease responsible for a considerable portion of
disabilities within the working population allover the world.
Although the riddle of how the contracture of the palmar fascia
develops is still unsolved, the data on the pathobiochemistry and
clinic of Dupuytren's Disease achieved in recent years has led to a
better understanding of the biochemical and morphological processes
underlying the deformation and malfunction of the afflicted
tissues. Research in Dupuytren's Disease now enters the era of
molecular medicine, which opens up new experimental means of
studying the pathological changes which occur during the formation
of the contracture on a molecular level. In particular, data are
presented as to the role of specific biological macromolecules
influencing the phenotype expression of the palmar fascia cells
which are involved in autoimmune reactions and present both at the
cell surface as well as in the extracellular matrix to regulate
cell-to-cell and cell-to-matrix interactions. In vitro cell culture
models to investigate fibro-cytic modulations are available and
havebeen applied to study the effects of specific biological
molecules on isolated cells from healthy palmar fascia and
Dupuytren's contracture. Complementary evaluations of
morphological, epidemiological, and clinical data contribute
essentially to the present understanding of the etiology and
pathogenesis of Dupuytren's Disease. This comprehensive and
informative summary of the state of the art is completed by
numerous references affixed to the individual contributions.
1,9 Millionen Deutsche sind vom Morbus Dupuytren betroffen. Eine
Rezidivrate von uber 50% nach chirurgischen Therapieversuchen
zeigt, dass die Erkrankung nicht ausschliesslich chirurgisch
behandelbar ist. In diesem Werk werden daher zwei Wege
eingeschlagen: Einerseits wird durch eine Beschreibung der
biochemischen und molekularbiologischen Veranderungen des
erkrankten Bindegewebes der systemische Charakter des Morbus
Dupuytren im Kontext mit anderen Bindegewebserkrankungen
hervorgehoben. Andererseits werden die unterschiedlichen
therapeutischen Ansatze aus einer differenzierten Darstellung der
anatomischen Gegebenheiten hergeleitet. Neben den Grundzugen
konservativer Therapie werden alle gangigen chirurgischen Verfahren
inklusive verfahrensspezifischer Komplikationen beschrieben sowie
zeichnerisch in ihren wesentlichen Zugen vorgestellt. Das Buch
wendet sich an alle, die eine aktuelle UEbersicht zum Morbus
Dupuytren wunschen und uber die etablierten Therapiekonzepte
instruktiv unterrichtet werden wollen.
This is a reproduction of a book published before 1923. This book
may have occasional imperfections such as missing or blurred pages,
poor pictures, errant marks, etc. that were either part of the
original artifact, or were introduced by the scanning process. We
believe this work is culturally important, and despite the
imperfections, have elected to bring it back into print as part of
our continuing commitment to the preservation of printed works
worldwide. We appreciate your understanding of the imperfections in
the preservation process, and hope you enjoy this valuable book.
++++ The below data was compiled from various identification fields
in the bibliographic record of this title. This data is provided as
an additional tool in helping to ensure edition identification:
++++ Petri Brenners Letzte Rede, Wie Er Durch Die Suder-Pforte Der
Stadt Stockholm Zu Einem Gewaltigen Tode Ausgefuhret Worden, Den
14./15. Julii Anno 1720 Peter Brenner
Andachten f r Kinder, kindgerecht zubereitet mit einer k stlichen
Beilage in Form eines Kinderkrimis- das ist Geschichtsandachten
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