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Dupuytren's Disease - Pathobiochemistry and Clinical Management (Paperback, Softcover reprint of the original 1st ed. 1994)
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Dupuytren's Disease - Pathobiochemistry and Clinical Management (Paperback, Softcover reprint of the original 1st ed. 1994)
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In this volume a distinguished group of internationally renowned
clinicians and basic researchers discuss the present state of
knowledge of the etiologyand pathogenesis of Dupuytren's
contracture, a disease responsible for a considerable portion of
disabilities within the working population allover the world.
Although the riddle of how the contracture of the palmar fascia
develops is still unsolved, the data on the pathobiochemistry and
clinic of Dupuytren's Disease achieved in recent years has led to a
better understanding of the biochemical and morphological processes
underlying the deformation and malfunction of the afflicted
tissues. Research in Dupuytren's Disease now enters the era of
molecular medicine, which opens up new experimental means of
studying the pathological changes which occur during the formation
of the contracture on a molecular level. In particular, data are
presented as to the role of specific biological macromolecules
influencing the phenotype expression of the palmar fascia cells
which are involved in autoimmune reactions and present both at the
cell surface as well as in the extracellular matrix to regulate
cell-to-cell and cell-to-matrix interactions. In vitro cell culture
models to investigate fibro-cytic modulations are available and
havebeen applied to study the effects of specific biological
molecules on isolated cells from healthy palmar fascia and
Dupuytren's contracture. Complementary evaluations of
morphological, epidemiological, and clinical data contribute
essentially to the present understanding of the etiology and
pathogenesis of Dupuytren's Disease. This comprehensive and
informative summary of the state of the art is completed by
numerous references affixed to the individual contributions.
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