In this volume a distinguished group of internationally renowned clinicians and basic researchers discuss the present state of knowledge of the etiologyand pathogenesis of Dupuytren's contracture, a disease responsible for a considerable portion of disabilities within the working population allover the world. Although the riddle of how the contracture of the palmar fascia develops is still unsolved, the data on the pathobiochemistry and clinic of Dupuytren's Disease achieved in recent years has led to a better understanding of the biochemical and morphological processes underlying the deformation and malfunction of the afflicted tissues. Research in Dupuytren's Disease now enters the era of molecular medicine, which opens up new experimental means of studying the pathological changes which occur during the formation of the contracture on a molecular level. In particular, data are presented as to the role of specific biological macromolecules influencing the phenotype expression of the palmar fascia cells which are involved in autoimmune reactions and present both at the cell surface as well as in the extracellular matrix to regulate cell-to-cell and cell-to-matrix interactions. In vitro cell culture models to investigate fibro-cytic modulations are available and havebeen applied to study the effects of specific biological molecules on isolated cells from healthy palmar fascia and Dupuytren's contracture. Complementary evaluations of morphological, epidemiological, and clinical data contribute essentially to the present understanding of the etiology and pathogenesis of Dupuytren's Disease. This comprehensive and informative summary of the state of the art is completed by numerous references affixed to the individual contributions.

1,9 Millionen Deutsche sind vom Morbus Dupuytren betroffen. Eine Rezidivrate von uber 50% nach chirurgischen Therapieversuchen zeigt, dass die Erkrankung nicht ausschliesslich chirurgisch behandelbar ist. In diesem Werk werden daher zwei Wege eingeschlagen: Einerseits wird durch eine Beschreibung der biochemischen und molekularbiologischen Veranderungen des erkrankten Bindegewebes der systemische Charakter des Morbus Dupuytren im Kontext mit anderen Bindegewebserkrankungen hervorgehoben. Andererseits werden die unterschiedlichen therapeutischen Ansatze aus einer differenzierten Darstellung der anatomischen Gegebenheiten hergeleitet. Neben den Grundzugen konservativer Therapie werden alle gangigen chirurgischen Verfahren inklusive verfahrensspezifischer Komplikationen beschrieben sowie zeichnerisch in ihren wesentlichen Zugen vorgestellt. Das Buch wendet sich an alle, die eine aktuelle UEbersicht zum Morbus Dupuytren wunschen und uber die etablierten Therapiekonzepte instruktiv unterrichtet werden wollen.

This is a reproduction of a book published before 1923. This book may have occasional imperfections such as missing or blurred pages, poor pictures, errant marks, etc. that were either part of the original artifact, or were introduced by the scanning process. We believe this work is culturally important, and despite the imperfections, have elected to bring it back into print as part of our continuing commitment to the preservation of printed works worldwide. We appreciate your understanding of the imperfections in the preservation process, and hope you enjoy this valuable book. ++++ The below data was compiled from various identification fields in the bibliographic record of this title. This data is provided as an additional tool in helping to ensure edition identification: ++++ Petri Brenners Letzte Rede, Wie Er Durch Die Suder-Pforte Der Stadt Stockholm Zu Einem Gewaltigen Tode Ausgefuhret Worden, Den 14./15. Julii Anno 1720 Peter Brenner

Andachten f r Kinder, kindgerecht zubereitet mit einer k stlichen Beilage in Form eines Kinderkrimis- das ist Geschichtsandachten