In the late 1980s, a promising new treatment for breast cancer emerged: high-dose chemotherapy with autologous bone marrow transplantation or HDC/ABMT. By the 1990s, it had burst upon the oncology scene and disseminated rapidly before having been carefully evaluated. By the time published studies showed that the procedure was ineffective, more than 30,000 women had received the treatment, shortening their lives and adding to their suffering. This book tells of the rise and demise of HDC/ABMT for metastatic and early stage breast cancer, and fully explores the story's implications, which go well beyond the immediate procedure, and beyond breast cancer, to how we in the United States evaluate other medical procedures, especially life-saving ones.
It details how the factors that drove clinical use--patient demand, physician enthusiasm, media reporting, litigation, economic exploitation, and legislative and administrative mandates--converged to propel the procedure forward despite a lack of proven clinical effectiveness. It also analyzes the limited effect of technology assessments before randomized clinical trials evaluated decisively the procedure and the ramifications of this system on healthcare today.
Sections of the book consider the initial conditions surrounding the emergence of the new breast cancer treatment, the drivers of clinical use, and the struggle for evidence-based medicine. A concluding section considers the significance of the story for our healthcare system.

Unlike some other reproductions of classic texts (1) We have not used OCR(Optical Character Recognition), as this leads to bad quality books with introduced typos. (2) In books where there are images such as portraits, maps, sketches etc We have endeavoured to keep the quality of these images, so they represent accurately the original artefact. Although occasionally there may be certain imperfections with these old texts, we feel they deserve to be made available for future generations to enjoy.

Eat Right 4 Your Type harnesses the power of our own amazing bio-chemistry to help you to cast aside the fad diets for good! Dr Peter D'Adamo and Catherine Whitney are back with a fully updated and revised edition of their sensational book to demonstrate how working with your blood type plays a key role in losing weight, avoiding disease and promoting fitness and longevity. After selling over a 7 million copies worldwide, this revised edition of the global phenomenon blood-type diet is packed with even more material - including a 10-Day Jump-Start Plan - to help you tailor your diet to suit you and your blood type, enabling you stay to healthy, live longer and achieve your ideal weight.

Advances in Digitalization and Machine Learning for Integrated Building-Transportation Energy Systems examines the combined impact of buildings and transportation systems on energy demand and use. With a strong focus on AI and machine learning approaches, the book comprehensively discusses each part of the energy life cycle, considering source, grid, demand, storage, and usage. Opening with an introduction to smart buildings and intelligent transportation systems, the book presents the fundamentals of AI and its application in renewable energy sources, alongside the latest technological advances. Other topics presented include building occupants’ behavior and vehicle driving schedule with demand prediction and analysis, hybrid energy storages in buildings with AI, smart grid with energy digitalization, and prosumer-based P2P energy trading. The book concludes with discussions on blockchain technologies, IoT in smart grid operation, and the application of big data and cloud computing in integrated smart building-transportation energy systems. A smart and flexible energy system is essential for reaching Net Zero whilst keeping energy bills affordable. This title provides critical information to students, researchers and engineers wanting to understand, design, and implement flexible energy systems to meet the rising demand in electricity.

Consciousness Mattering presents a contemporary Buddhist theory in which brains, bodies, environments, and cultures are relational infrastructures for human consciousness. Drawing on insights from meditation, neuroscience, physics, and evolutionary theory, it demonstrates that human consciousness is not something that occurs only in our heads and consists in coherent differentiation—the creative elaboration of relations among sensed and sensing presences, and more fundamentally between matter and what matters. Hershock argues that without consciousness there would only be either unordered sameness or nothing at all. Evolution is consciousness mattering. Shedding new light on the co-emergence of subjective awareness and culture, the possibility of machine consciousness, the risks of algorithmic consciousness hacking, and the potentials of intentionally altered states of consciousness, Hershock invites us to consider how freely, wisely, and compassionately consciousness matters.

Organogenesis of the kidney has been intensely studied for over a century. In recent years advances in molecular techniques have not only made great inroads into exploring the genetic regulation of this complex process but also began to unravel the molecular basis of many forms of congenital kidney disease. This book is a comprehensive study on these findings and the only book available with such in depth coverage of the kidney.
Key Features
* Hundreds of color figures depicting key events in all aspects of kidney development
* Full coverage of the genetic and cellular basis of kidney development
* Analysis of the genetic basis of the major congenital kidney diseases

From the legendary vice-chairman of Berkshire Hathaway, lessons in investment strategy, philanthropy, and living a rational and ethical life. “A timeless classic that will change how you approach life. There is a billion-dollar education inside this book.� —Shane Parrish, founder of Syrus Partners and Farnam Street “Spend each day trying to be a little wiser than you were when you woke up,� Charles T. Munger advises in Poor Charlie’s Almanack. Originally published in 2005, this compendium of eleven talks delivered by the legendary Berkshire Hathaway vice-chairman between 1986 and 2007 has become a touchstone for a generation of investors and entrepreneurs seeking to absorb the enduring wit and wisdom of one of the great minds of the 20th and 21st centuries.  Edited by Peter D. Kaufman, chairman and CEO of Glenair and longtime friend of Charlie Munger—whom he calls “this generation’s answer to Benjamin Franklin�—this abridged Stripe Press edition of Poor Charlie’s Almanack features a brand-new foreword by Stripe cofounder John Collison.   Poor Charlie’s Almanack draws on Munger’s encyclopedic knowledge of business, finance, history, philosophy, physics, and ethics—and more besides—to introduce the latticework of mental models that underpin his rational and rigorous approach to life, learning, and decision-making. Delivered with Munger’s characteristic sharp wit and rhetorical flair, it is an essential volume for any reader seeking to go to bed a little wiser than when they woke up.

This volume represents a contribution to the growing literature on international and comparative climate change policy. The product of a research project of the International Bar Association Section on Energy and Natural Resources Law (SERL), it brings together leading academic lawyers from around the world, who provide detailed perspectives on what individual countries are doing (or, in some cases, not doing) to address the climate change problem. The book illustrates the range of national actions to reduce greenhouse gas emissions, including incentives for renewable energy sources, forestry activities, voluntary agreements with industry, and emissions trading schemes. By including experts from both industrialized and developing countries, it also highlights the very differing perspectives that must be addressed in any international climate change regime, whether under Kyoto or a successor. These detailed case studies provide a rich array of material, which should be of significant interest not only to academic and business lawyers, but also to economists and energy experts, government officials, and NGOs.

Chan Buddhism has become paradigmatic of Buddhist spirituality. Known in Japan as Zen and in Korea as Son, it is one of the most strikingly iconoclastic spiritual traditions in the world. This succinct and lively work clearly expresses the meaning of Chan as it developed in China more than a thousand years ago and provides useful insights into the distinctive aims and forms of practice associated with the tradition, including its emphasis on the unity of wisdom and practice; the reality of "sudden awakening"; the importance of meditation; the use of "shock tactics"; the centrality of the teacher-student relationship; and the celebration of enlightenment narratives, or koans. Unlike many scholarly studies, which offer detailed perspectives on historical development, or guides for personal practice written by contemporary Buddhist teachers, this volume takes a middle path between these two approaches, weaving together both history and insight to convey to the general reader the conditions, energy, and creativity that characterize Chan. Following a survey of the birth and development of Chan, its practices and spirituality are fleshed out through stories and teachings drawn from the lives of four masters: Bodhidharma, Huineng, Mazu, and Linji. Finally, the meaning of Chan as a living spiritual tradition is addressed through a philosophical reading of its practice as the realization of wisdom, attentive mastery, and moral clarity.

This fully updated second edition explores protocols that address the most challenging aspects of experimental work in ancient DNA, such as preparing ancient samples for DNA extraction, the DNA extraction itself, and transforming extracted ancient DNA molecules for sequencing library preparation. The volume also examines the analysis of high-throughput sequencing data recovered from ancient specimens, which, because of the degraded nature of ancient DNA and common co-extraction of contaminant DNA, has challenges that are unique compared to data recovered from modern specimens.Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and cutting-edge, Ancient DNA: Methods and Protocols, Second Edition aims to serve both experts and beginners by presenting protocols in a manner that makes them easily accessible for everyday use in the lab.

The author lucidly describes his key role in political and economic strategies that have influenced the actions of government, both nationally and internationally over thirty five years.