In the late 1980s, a promising new treatment for breast cancer emerged: high-dose chemotherapy with autologous bone marrow transplantation or HDC/ABMT. By the 1990s, it had burst upon the oncology scene and disseminated rapidly before having been carefully evaluated. By the time published studies showed that the procedure was ineffective, more than 30,000 women had received the treatment, shortening their lives and adding to their suffering. This book tells of the rise and demise of HDC/ABMT for metastatic and early stage breast cancer, and fully explores the story's implications, which go well beyond the immediate procedure, and beyond breast cancer, to how we in the United States evaluate other medical procedures, especially life-saving ones.
It details how the factors that drove clinical use--patient demand, physician enthusiasm, media reporting, litigation, economic exploitation, and legislative and administrative mandates--converged to propel the procedure forward despite a lack of proven clinical effectiveness. It also analyzes the limited effect of technology assessments before randomized clinical trials evaluated decisively the procedure and the ramifications of this system on healthcare today.
Sections of the book consider the initial conditions surrounding the emergence of the new breast cancer treatment, the drivers of clinical use, and the struggle for evidence-based medicine. A concluding section considers the significance of the story for our healthcare system.

From the legendary vice-chairman of Berkshire Hathaway, lessons in investment strategy, philanthropy, and living a rational and ethical life. “A timeless classic that will change how you approach life. There is a billion-dollar education inside this book.� —Shane Parrish, founder of Syrus Partners and Farnam Street “Spend each day trying to be a little wiser than you were when you woke up,� Charles T. Munger advises in Poor Charlie’s Almanack. Originally published in 2005, this compendium of eleven talks delivered by the legendary Berkshire Hathaway vice-chairman between 1986 and 2007 has become a touchstone for a generation of investors and entrepreneurs seeking to absorb the enduring wit and wisdom of one of the great minds of the 20th and 21st centuries.  Edited by Peter D. Kaufman, chairman and CEO of Glenair and longtime friend of Charlie Munger—whom he calls “this generation’s answer to Benjamin Franklin�—this abridged Stripe Press edition of Poor Charlie’s Almanack features a brand-new foreword by Stripe cofounder John Collison.   Poor Charlie’s Almanack draws on Munger’s encyclopedic knowledge of business, finance, history, philosophy, physics, and ethics—and more besides—to introduce the latticework of mental models that underpin his rational and rigorous approach to life, learning, and decision-making. Delivered with Munger’s characteristic sharp wit and rhetorical flair, it is an essential volume for any reader seeking to go to bed a little wiser than when they woke up.

Unlike some other reproductions of classic texts (1) We have not used OCR(Optical Character Recognition), as this leads to bad quality books with introduced typos. (2) In books where there are images such as portraits, maps, sketches etc We have endeavoured to keep the quality of these images, so they represent accurately the original artefact. Although occasionally there may be certain imperfections with these old texts, we feel they deserve to be made available for future generations to enjoy.

Elgar Advanced Introductions are stimulating and thoughtful introductions to major fields in the social sciences, business and law, expertly written by the world's leading scholars. Designed to be accessible yet rigorous, they offer concise and lucid surveys of the substantive and policy issues associated with discrete subject areas.

Elgar Advanced Introductions are stimulating and thoughtful introductions to major fields in the social sciences, business and law, expertly written by the world's leading scholars. Designed to be accessible yet rigorous, they offer concise and lucid surveys of the substantive and policy issues associated with discrete subject areas.

Elgar Research Agendas outline the future of research in a given area. Leading scholars are given the space to explore their subject in provocative ways and map out the potential directions of travel. They are relevant but also visionary. This enlightening Research Agenda considers the latest developments within the world of work, arguing that the time is right to address the variety of Human Resource Management (HRM) practices and arrangements. Helping readers to deepen their theoretical understanding of HRM systems and processes, this Research Agenda brings insights from strategic human capital and theories that have been outside the main focus of strategic HRM researchers. Chapters look at attribution theories, the role of human and social capital in strategic HRM, as well as institutional or social forces that affect firm choices of HRM practices and outcomes. The book takes us beyond a best practice view by examining online labour platforms, the liquid workforce, networked organizations, and the management of human resources in entrepreneurial firms. Exploring the varying forms of HRM systems and practices, this book will be a key resource for scholars and PhD students in the fields of human resource management and strategic management.

Advances in Digitalization and Machine Learning for Integrated Building-Transportation Energy Systems examines the combined impact of buildings and transportation systems on energy demand and use. With a strong focus on AI and machine learning approaches, the book comprehensively discusses each part of the energy life cycle, considering source, grid, demand, storage, and usage. Opening with an introduction to smart buildings and intelligent transportation systems, the book presents the fundamentals of AI and its application in renewable energy sources, alongside the latest technological advances. Other topics presented include building occupants’ behavior and vehicle driving schedule with demand prediction and analysis, hybrid energy storages in buildings with AI, smart grid with energy digitalization, and prosumer-based P2P energy trading. The book concludes with discussions on blockchain technologies, IoT in smart grid operation, and the application of big data and cloud computing in integrated smart building-transportation energy systems. A smart and flexible energy system is essential for reaching Net Zero whilst keeping energy bills affordable. This title provides critical information to students, researchers and engineers wanting to understand, design, and implement flexible energy systems to meet the rising demand in electricity.

Volume 20 of Research in Occupational Stress and Well Being features contributions that expand the understanding of how occupational stressors can build employee resilience and enhance their well-being while at the same time creating negative employee outcomes such as depletion, exhaustion, and depression. To this end, chapters take a hard look at examining the outcomes of work stressors, the circumstances or conditions that can change or even reverse the relationship between stressors and outcomes, and theoretical accounts for apparent contradictions in this literature. Examining the Paradox of Occupational Stressors: Building Resilience or Creating Depletion represents insightful, intriguing, and timely research into the paradox of experienced stress in the workplace.

This title is part of UC Press's Voices Revived program, which commemorates University of California Press’s mission to seek out and cultivate the brightest minds and give them voice, reach, and impact. Drawing on a backlist dating to 1893, Voices Revived makes high-quality, peer-reviewed scholarship accessible once again using print-on-demand technology. This title was originally published in 1984.

Eat Right 4 Your Type harnesses the power of our own amazing bio-chemistry to help you to cast aside the fad diets for good! Dr Peter D'Adamo and Catherine Whitney are back with a fully updated and revised edition of their sensational book to demonstrate how working with your blood type plays a key role in losing weight, avoiding disease and promoting fitness and longevity. After selling over a 7 million copies worldwide, this revised edition of the global phenomenon blood-type diet is packed with even more material - including a 10-Day Jump-Start Plan - to help you tailor your diet to suit you and your blood type, enabling you stay to healthy, live longer and achieve your ideal weight.

Consciousness Mattering presents a contemporary Buddhist theory in which brains, bodies, environments, and cultures are relational infrastructures for human consciousness. Drawing on insights from meditation, neuroscience, physics, and evolutionary theory, it demonstrates that human consciousness is not something that occurs only in our heads and consists in coherent differentiation—the creative elaboration of relations among sensed and sensing presences, and more fundamentally between matter and what matters. Hershock argues that without consciousness there would only be either unordered sameness or nothing at all. Evolution is consciousness mattering. Shedding new light on the co-emergence of subjective awareness and culture, the possibility of machine consciousness, the risks of algorithmic consciousness hacking, and the potentials of intentionally altered states of consciousness, Hershock invites us to consider how freely, wisely, and compassionately consciousness matters.

The author lucidly describes his key role in political and economic strategies that have influenced the actions of government, both nationally and internationally over thirty five years.