Bioassays are among the ecotoxicologist's most effective weapons in the evaluation of water quality and the assessment of ecological impacts of effluents, chemicals, discharges, and emissions on the aquatic environment. Information on these assessment aids is needed throughout the international scientific and environmental management community. This comprehensive reference provides an excellent overview of the small-scale aquatic bioassay techniques and applications currently in use around the world.
This special volume is the result of several years of collaboration between Environment Canada and Fisheries and Oceans Canada. Internationally recognized research scientists at many institutions have contributed to this state-of-the-art examination of the exciting, environmentally important field of microscale testing in aquatic toxicology.
Microscale Testing in Aquatic Toxicology contains over forty chapters covering relevant principles, new techniques and recent advancements, and applications in scientific research, environmental management, academia, and the private sector.

A compilation of researchers' experience in the areas of bioanalysis, pharmacokinetics, and drug metabolism, to present an up-to-date and comprehensive treatise on the application of these and related technologies in drug discovery, development, and clinical use. Contents cover descriptions of analytical methods, in vitro metabolism technology and membrane transport, reappraisal of classical pharmacokinetic problems, and the time course of drug action. The book concludes with a description of PET and imaging methods in pharmacokinetics and an appendix containing a critical appraisal of computer methods and pharmacokinetic software available for PCs.

Over the years a number of excellent books have classified and detailed drug drug interactions into their respective categories, e.g. interactions at plasma protein binding sites; those altering intestinal absorption or bioavailability; those involving hepatic metabolising enzymes; those involving competition or antagonism for receptor sites, and drug interactions modifying excretory mechanisms. Such books have presented extensive tables of interactions and their management. Although of considerable value to clinicians, such publica tions have not, however, been so expressive about the individual mechanisms that underlie these interactions. It is within this sphere of "mechanisms" that this present volume specialises. It deals with mechanisms of in vitro and in vivo, drug-drug, drug food and drug-herbals interactions and those that cause drugs to interfere with diagnostic laboratory tests. We believe that an explanation of the mechanisms of such interactions will enable practitioners to understand more fully the nature of the interactions and thus enable them to manage better their clinical outcome. If mechanisms of interactions are better understood, then it may be pos sible for the researcher to develop meaningful animal/biochemical/tissue cul ture or physicochemical models to which new molecules could be exposed during their development stages. The present position, which largely relies on patients experiencing adverse interactions before they can be established or documented, can hardly be regarded as satisfactory. This present volume is classified into two major parts; firstly, pharmacoki netic drug interactions and, secondly, pharmacodynamic drug interactions."

This book provides a timely analysis of the role that information-particularly scientific information-plays in the policy-making and decision-making processes in coastal and ocean management. It includes contributions from global experts in marine environmental science, marine policy, fisheries, public policy and administration, resource management, risk management, and information management. The book is divided into four sections that provide focused analyses, including An overview of the characteristics of the science-policy interface, including a discussion of the role of scientific information in policy making and an argument that the term "science-policy interface" is inaccurate due to the existence of many possible interfaces Descriptions of fundamental concepts and principles for understanding the role of information in effective integrated coastal and ocean management National and international case studies that illustrate key factors in successful science-policy interfaces, such as awareness, communication, and use of information Critical issues and future research challenges The book also explores the different types of science-policy interfaces existing within and between different organizations, as well as the various roles that different types of non-governmental organizations play in producing and disseminating information. Science, Information, and Policy Interface for Effective Coastal and Ocean Management presents a wealth of knowledge that enhances current best practices to achieve more effective communication and use of marine environmental information. Useful to all major groups in the policy-making process, from senior policy- and decision-makers to practitioners in coastal and ocean management, it helps to increase understanding of catalysts and barriers to communicating research findings. It also serves as a starting point for further research and progress in efficient marine environment management. The Open Access version of this book, available at https://doi.org/10.1201/b21483, has been made available under a Creative Commons Attribution-Non Commercial-No Derivatives 4.0 license.