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The book presents a basis for the interaction of the brain and
nervous system with painting, music and literature, and a
discussion of art from multiple facets such as anatomy, migraine,
illusion and evolutionary biology. The book explores several
aspects of the neurobiology of painting, including evolutionary
neurobiology, sensation vs. perception, the visual brain and how
the mind works, and also explores the affects of brain disorders
and trauma on artist, with a concluding chapter on Frida Kahlo and
the spinal cord injury that influenced her painting.
Glutamate and GABA are the main information carrying
neurotransmitters in the brain. Their action is modulated by a
further series of small molecules called neuromodulators. The major
neuromodulators in the brain are acetylcholine (both muscarinic and
nicotinic), dopamine, norepinephrine, epinephrine and serotonin.
These have an enormous range of functions in a wide variety of
brain mechanisms. This book attempts to give a general overview of
this field with a section devoted to each of these. Each section
starts with anatomy, both structural and functional. The various
types of receptors for these agents are described and then the
effects of stimulating these receptors. These receptors trigger a
variety of electrical reactions that generally involve potassium,
sodium or calcium channels. Also reviewed are other receptors that
trigger a wide variety of post-synaptic signaling cascades that
influence a large number of neuronal functions including receptor
sensitivity, synaptic plasticity and gene manipulation. Finally the
relevance of these systems to disease states is detailed. There are
many reviews of individual neuromodulators but this is the only
book where one author attempts to cover the whole field.
International Review of Neurobiology is a well-respected series
appealing to neuroscientists, clinicians, psychologists,
physiologists, and pharmacologists. Led by an internationally
renowned editorial board, this important serial publishes both
eclectic volumes made up of timely reviews and thematic volumes
that focus on recent progress in a specific area of neurobiology
research. This volume is a cumulative subject index of volumes
26-50.
International Review of Neurobiology is a well-respected series
appealing to neuroscientists, clinicians, psychologists,
physiologists, and pharmacologists. Led by an internationally
renowned editorial board, this important serial publishes both
eclectic volumes made up of timely reviews and thematic volumes
that focus on recent progress in a specific area of neurobiology
research. This volume is a cumulative subject index of volumes
1-25.
Volume 42 presents an in-depth review on Alzheimer's Disease as
well as a look at several transcription factors.
Key Features
* Clinical features of stroke and the current stasis of stroke
therapy
* Alzheimers Disease--pathology, pathological proteins, etiology,
pathogenesis, neurotransmitter alterations, and treatment
strategies
* An examination of the regulation of AP-1 and related
transcription factors and their role in brain injury and drug
abuse-related behavior
* Emerging roles of the transcription factor NF(B
* Recent advances about the nature of alterations in ion channel
structure or function which may be responsible for
epileptogenesis
* An integrated model accounting for the multiple mechanisms
involved in the posttranslational regulation of glutamate ionotroic
receptors
* Genetic mutation and the Glycine Receptor
Published since 1959, International Review of Neurobiology is a
well-known series appealing to neuroscientists, clinicians,
psychologists, physiologists, and pharmacologists. Led by an
internationally renowned editorial board, this important serial
publishes both eclectic volumes made up of timely reviews and
thematic volumes that focus on recent progress in a specific area
of neurobiology research. This volume reviews existing theories and
current research surrounding the movement disorder Dyskinesia.
Leading authors review state-of-the-art in their field of
investigation and provide their views and perspectives for future
research
Chapters are extensively referenced to provide readers with a
comprehensive list of resources on the topics covered
All chapters include comprehensive background information and are
written in a clear form that is also accessible to the
non-specialist
Published since 1959, International Review of Neurobiology is a
well-known series appealing to neuroscientists, clinicians,
psychologists, physiologists, and pharmacologists. Led by an
internationally renowned editorial board, this important serial
publishes both eclectic volumes made up of timely reviews and
thematic volumes that focus on recent progress in a specific area
of neurobiology research.
This volume is a collection of chapters covering recent advances in
the field of neurobiology. Chapters address anesthetic binding
sites on the nicotinic acetylcholine receptors, NMDA receptor
signal regulation, alcohol self-administration in rodents, and
dopamine receptor mutations in mice.
Published since 1959, International Review of Neurobiology is a
well-known series appealing to neuroscientists, clinicians,
psychologists, physiologists, and pharmacologists. Led by an
internationally renowned editorial board, this important serial
publishes both eclectic volumes made up of timely reviews and
thematic volumes that focus on recent progress in a specific area
of neurobiology research.
This volume is a collection of chapters covering recent advances in
the field of neurobiology. Chapters address anesthetic binding
sites on the nicotinic acetylcholine receptors, NMDA receptor
signal regulation, alcohol self-administration in rodents, and
dopamine receptor mutations in mice.
International Review of Neurobiology, Volume 46 presents in-depth
reviews on such ground-breaking topics as assembly and
intracellular trafficking of GABA A receptors, D-1 dopamine
receptors, and Alzheimer's disease. This series offers the most
comprehensive and up-to-date information available and is a must
for anyone in the field.
Includes a historical overview of neurosteroid research
Contains a chapter on neurosteroid biosynthesis and
regulation
Presents current methods of neurosteroid measurement and
analysis
Discusses neurosteroid function in both the normal and the
pathological brain
Chapters address the function of neurosteroid in:
Stress
Receptor plasticity and function
Learning and Memory
Alcohol use
Depression
When we walk, drive a car, or fly an airplane, visual motion is
used to control and guide our movement. Optic flow describes the
characteristic pattern of visual motion that arises in these
situations. This book is the first to take an in-depth look at the
neuronal processing strategies that underlie the brain's ability to
analyze and use optic flow for the control of self-motion. It does
so in a variety of species which use optic flow in different
behavioral contexts. The spectrum ranges from flying insects to
birds, higher mammals and man. The contributions cover
physiological and behavioral studies as well as computational
models. Neuronal Processing of Optic Flow provides an authoritative
and comprehensive overview of the current state of research on this
topic written by a group of authors who have made essential
contributions to shaping this field of research over the last ten
years.
Key Features
* Provides the first detailed overview of the analysis of complex
visual motion patterns in the brain
* Includes physiological, behavioral, and computational aspects of
optic flow processing
* Highlights similarities and differences between different animal
species and behavioral tasks
* Covers human patients with visual motion deficits
* Enhances the reader's understanding with many illustrations
Autonomic dysfunction is one of the most prevalent non-motor
symptoms that occurs in Parkinson's disease. Autonomic Dysfunction
in Parkinson's Disease provides up to date information on this
important topic, which affects quality of life of these patients.
This include a large number of domains: orthostatic hypotension,
excessive sweating, dry eyes, constipation, weight loss, increased
sensitivity to heat and cold, sexual dysfunction.
Neuroscience Perspectives provides multidisciplinary reviews of
topics in one of the most diverse and rapidly advancing fields in
the life sciences.
Whether you are a new recruit to neuroscience, or an established
expert, look to this series for 'one-stop' sources of the
historical, physiological, pharmacological, biochemical, molecular
biological and therapeutic aspects of chosen research areas.
The last decade has seen tremendous advances in our understanding
of the pathobiology of Alzheimer's disease. These will lead to the
first generation of drugs aimed at prevention rather than cure.
This book covers some of the most important and exciting of these
advances, with chapters written by many of the leading researchers
in the field.
With genetic studies as a backbone to this volume many chapters are
devoted to the function and regulation of amyloid b-protein
precursor (APP) and apolipoprotein E (ApoE). Other chapters
describe cell biological approaches helping to piece together the
link between the genetic alterations and the phenotype we call
Alzheimer's disease.
Although APP and its proteolytic cleavage product, amyloid
b-protein, do not answer all the questions, detailed research into
this system has undoubtedly increased our knowledge of the
pathobiology of AD and has lead to the identification of other risk
factors. Understanding the role of ApoE in the pathology of
Alzheimer's disease promises to open a whole new field in AD
research.
*
* Reviews the current knowledge of the pathogenesis of Alzheimer's
Disease from a clinical perspective to a genetic and cell
biological perspective
* A comprehensive description of the role of amyloid B-protein
precursor in Alzheimer's disease.
* Up-to-date research data
* Clear illustrations complement the text
Neuroscience Perspectives provides multidisciplinary reviews of
topics in one of the most diverse and rapidly advancing fields in
the life sciences. Whether you are a new recruit to neuroscience,
or an established expert, look to this series for 'one-stop'
sources of the historical, physiological, pharmacological,
biochemical, molecular biological and therapeutic aspects of chosen
research areas. The sigma receptor was originally thought to be a
subset of the opioid receptor family, and it is less than 10 years
since it was recognized that this receptor represents unique
binding sites in mammalian brain and peripheral organs, distinct
from any other known neurotransmitter receptor. Since the sigma
receptors exhibit high affinity for members of diverse classes of
psychotropic drugs, and have been postulated to be involved in
various central nervous disorders, neuroscientists have
demonstrated a great deal of interest in the elucidation of these
receptor sites and their biological relevance. Relatively little is
known about the precise role of sigma receptors in normal brain
function and in CNS disorders, despite an overwhelming research
effort. This research has resulted in many controversies, some of
which have been reconciled while others have not. This volume aims
to update the reader on the current situation, and deals with the
potential functional significance of these receptors in the brain
and peripheral organs and, where appropriate, makes reference to
the clinical potential of these sites.
Neuroscience Perspectives provides multidisciplinary reviews of
topics in one of the most diverse and rapidly advancing fields in
the life sciences.
Whether you are a new recruit to neuroscience, or an established
expert, look to this series for 'one-stop' sources of the
historical, physiological, pharmacological, biochemical, molecular
biological and therapeutic aspects of chosen research areas.
Although peripheral type benzodiazepne recognition sites have been
demonstrated in the brain and peripheral organs of various species
for more than 10 years, the exact physiological function or
pharmacological effects have not yet been established. Peripheral
benzodiazepine literature is so overwhelming that the novice may
find it virtually impossible to form a clear idea about the diverse
findings.
This volume, dedicated exclusively to pBR and their natural and
synthetic ligands, puts the available data into perspective.
A truly interdisciplinary approach has brought neuroscientists,
cardiologists, endocrinologists, and immunologists together to work
on the description of pBR-mediated effects. The chemistry,
biochemistry, and molecular biology of the pBR receptor and its
ligands are reviewed, their pharmacological usefulness is
conjectured, and thus a true overview of the field is provided.
* SPECIAL FEATURES
* This volume follows the Neuroscience Perspectives brief of
providing a historical background, pharmacological, biochemical and
physiological aspects of research and therapeutic potential, of its
chosen topic.
* The peripheral benzodiazepine recognition site has been
recognised for more than ten years, but the exact physiological and
pharmacological effects have not yet been established.
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