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Expert clinicians and basic scientists with a special interest in
Parkinson's disease review the current state of science and
clinical therapeutics of the disease. Therefore these articles
represent an authorative review of the current state of knowledge
regarding preclinical course and symptomatology, subtypes with
their impact on the pathology, genetic alterations, novel
mechanisms of neuronal cell death, diagnostic tools and old and
novel therapeutic approaches with respect to neuroprotection and
neuroregeneration in Parkinson's disease. Particular emphasis has
been placed on a novel antiparkinsonian drug called budipine with
various modes of action also influencing altered non dopaminergic
systems in Parkinson's disease. It is evident, that many questions
on the cause, course and treatment of Parkinson's disease are still
unanswered and therefore the ideal way to treat a parkinsonian
patient remains to be defined.
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