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In this book, leading-edge investigators offer effective strategies
to improve current antidepressive therapies and suggest molecular,
biological, and genetic approaches that will lead to the
development of novel antidepressants. The contributors' critical
reviews and commentaries illuminate our understanding of the
mechanism(s) responsible for antidepressant action. The book's goal
is to move beyond current biogenic amine-based concepts and
therapies to the development of new and improved antidepressants
that are more effective and have a more rapid onset than current.
Molecular Bases of Anesthesia provides a clear overview of the state of knowledge about anesthetic mechanisms at the molecular level of occurrence and focusing on the latest state-of-the-art techniques that relate to how anesthetic drugs cause unconsciousness.
With contributions by leading experts, this timely book includes chapters on how to evaluate theories of anesthesia in general and includes discussion of some of the techniques, such as genetics, that can be used to address problems. Also discussed are anesthetic actions at major brain targets with a special emphasis on ion channels and areas of controversy in the field.
This reference provides a broad survey of anesthetic actions, including hyperbaric pressure and anesthesia; volatile anesthetic interactions with proteins; and structure activity relationships of volatile anesthetics. Molecular Bases of Anesthesia stands alone as an in-depth, authoritative guide.
In this book, leading-edge investigators offer effective strategies
to improve current antidepressive therapies and suggest molecular,
biological, and genetic approaches that will lead to the
development of novel antidepressants. The contributors' critical
reviews and commentaries illuminate our understanding of the
mechanism(s) responsible for antidepressant action. The book's goal
is to move beyond current biogenic amine-based concepts and
therapies to the development of new and improved antidepressants
that are more effective and have a more rapid onset than current.
Both metabotropic and ionotropic glutamate receptors present
attractive "druggable" targets in treating disorders of the central
nervous system. There has been a dramatic shift in the focus of
glutamate-based therapies away from neurologic disorders such as
stroke and traumatic brain injury to the treatment of psychiatric
disorders. This "Milestones in Drug Therapy" volume offers a
unique, contemporary overview of preclinical and clinical evidence
that modulating glutamatergic tone is an effective means of
treating psychiatric disorders ranging from depression and anxiety
to schizophrenia and drug abuse. The ability to treat diseases such
as depression and schizophrenia through multiple, glutamate-based
mechanisms offers a unique therapeutic opportunity, as described in
this book.
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