Both metabotropic and ionotropic glutamate receptors present
attractive "druggable" targets in treating disorders of the central
nervous system. There has been a dramatic shift in the focus of
glutamate-based therapies away from neurologic disorders such as
stroke and traumatic brain injury to the treatment of psychiatric
disorders. This "Milestones in Drug Therapy" volume offers a
unique, contemporary overview of preclinical and clinical evidence
that modulating glutamatergic tone is an effective means of
treating psychiatric disorders ranging from depression and anxiety
to schizophrenia and drug abuse. The ability to treat diseases such
as depression and schizophrenia through multiple, glutamate-based
mechanisms offers a unique therapeutic opportunity, as described in
this book.
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