This issue of Medical Clinics covers the important advances surrounding the early intervention of Alzheimer's Disease. Guest edited by world-renowned experts from around the world, the topics covered will include evaluation of new diagnostic criteria, CSF biomarkers, diagnostic imaging, neurocognitive approaches, breaking clinical trials and more.

This is the first work to take a comprehensive look at the application of Magnetic Resonance (MR) techniques in the diagnosis, follow-up and therapy monitoring of dementing illnesses. The authors present an overview of MR findings in neurodegenerative and vascular disorders leading to dementia. In doing so, they also discuss other diseases that lead to cognitive and/or behavioural deterioration, such as infectious inflammatory disorders, toxic encephalopathies, inborn errors of metabolism of adult onset and post-traumatic, post-radiotherapy and post-chemotherapy conditions. This authoritative, well-written and richly illustrated reference work is indispensable for anybody working in the field.

Functional magnetic resonance imaging (FMRI) has become the most widely used method for imaging normal brain function in a relatively short period of time. The use of FMRI in clinically related research has been much slower; however, FMRI is now becoming a valuable tool in the study of many neurological and psychiatric disorders. This book explains the status of current clinical applications of FMRI in preoperative evaluation, diagnosis and discrimination of pathology, and in understanding recovery, therapeutics and rehabilitation of neurological and psychiatric conditions. Individual chapters cover the use of FMRI in the preoperative assessment of both motor function and language as well as in the assessment of age-related changes in memory. More focused chapters cover the use of FMRI in specific medical conditions including dementia, schizophrenia, depression and anxiety disorders, stroke, Parkinson's disease and multiple sclerosis. The book concludes with a chapter on the role of FMRI in monitoring changes in brain function following exposure to clinical pharmacotherapeutics and experimental drug compounds. This book will be of interest to both novice FMRI researchers and expert FMRI scientists as well as to clinicans in neurology, radiology and psychiatry.