The field of statistics not only affects all areas of scientific activity, but also many other matters such aspublic policy. It is branching rapidly into so many different subjects that a series of handbooks is the only way of comprehensively presenting the various aspects of statistical methodology, applications, and recent developments.

The Handbook of Statistics, a series of self-contained reference books. Each volume is devoted to a particular topic in statistics with Volume 28 dealing with bioinformatics. Every chapter is written by prominent workers in the area to which the volume is devoted. The series is addressed to the entire community of statisticians and scientists in various disciplines who use statistical methodology in their work. At the same time, special emphasis is placed on applications-oriented techniques, with the applied statistician in mind as the primary audience.
Comprehensively presents the various aspects of statistical methodologyDiscusses a wide variety of diverse applications and recent developmentsContributors are internationally renowned experts in their respective areas"

Linear models, normally presented in a highly theoretical and mathematical style, are brought down to earth in this comprehensive textbook. Linear Models examines the subject from a mean model perspective, defining simple and easy-to-learn rules for building mean models, regression models, mean vectors, covariance matrices and sums of squares matrices for balanced and unbalanced data sets. The author includes both applied and theoretical discussions of the multivariate normal distribution, quadratic forms, maximum likelihood estimation, less than full rank models, and general mixed models. The mean model is used to bring all of these topics together in a coherent presentation of linear model theory.
Key Features
* Provides a versatile format for investigating linear model theory, using the mean model
* Uses examples that are familiar to the student:
* design of experiments, analysis of variance, regression, and normal distribution theory
* Includes a review of relevant linear algebra concepts
* Contains fully worked examples which follow the theorem/proof presentation

Professor Herbert A. David of Iowa State University will be turning 70 on December 19, 1995. He is reaching this milestone in life with a very distinguished career as a statistician, educator and administrator. We are bringing out this volume in his honor to celebrate this occasion and to recognize his contributions to order statistics, biostatistics and design of experiments, among others; and to the statistical profession in general. With great admiration, respect and pleasure we dedicate this festschrift to Professor Herbert A. David, also known as Herb and H.A. among his friends, colleagues and students. When we began this project in Autumn 1993 and contacted potential contributors from the above group, the enthu siasm was phenomenal. The culmination of this collective endeavor is this volume that is being dedicated to him to celebrate his upcoming birthday. Several individuals have contributed in various capacities to the success ful completion of this project. We sincerely thank the authors of the papers appearing here. Without their dedicated work, we would just have this pref ace Many of them have served as (anonymous) referees as well. In addition, we are thankful to the following colleagues for their time and advice: John Bunge (Cornell), Z. Govindarajulu (Kentucky), John Klein (Medical U."

This text bridges the gap between sound theoretcial developments and practical, fruitful methodology by providing solid justification for standard symptotic statistical methods. It contains a unified survey of standard large sample theory and provides access to more complex statistical models that arise in diverse practical applications.

This text bridges the gap between sound theoretcial developments and practical, fruitful methodology by providing solid justification for standard symptotic statistical methods. It contains a unified survey of standard large sample theory and provides access to more complex statistical models that arise in diverse practical applications.

Exact statistical inference may be employed in diverse fields of science and technology. As problems become more complex and sample sizes become larger, mathematical and computational difficulties can arise that require the use of approximate statistical methods. Such methods are justified by asymptotic arguments but are still based on the concepts and principles that underlie exact statistical inference. With this in perspective, this book presents a broad view of exact statistical inference and the development of asymptotic statistical inference, providing a justification for the use of asymptotic methods for large samples. Methodological results are developed on a concrete and yet rigorous mathematical level and are applied to a variety of problems that include categorical data, regression, and survival analyses. This book is designed as a textbook for advanced undergraduate or beginning graduate students in statistics, biostatistics, or applied statistics but may also be used as a reference for academic researchers.

On behalf of those of us who in various ways have con tributed to this volume, and on behalf of all of his colleagues, students and friends throughout the world-wide scientific com munity, we dedicate this volume to Gopinath Kallianpur as a tribute to his work and in appreciation for the insights which he has so graciously and generously offered, and continues to offer, to all of us. Stochastic Processes contains 41 articles related to and frequently influ enced by Kallianpur's work. We regret that space considerations prevented us from including contributions from his numerous colleagues (at North Carolina, lSI, Minnesota, Michigan), former students, co-authors and other eminent scientists whose work is akin to Kallianpur's. This would have taken several more volumes All articles have been refereed, and for their valuable assistance in this we thank many of the contributing authors, as well as: R. Bradley, M.H.A. Davis, R. Davis, J. Hawkins, J. Horowitz, C. Houdre, N.C. Jain, C. Ji, P. Kokoszka, T. Kurtz, K.S. Lau, W. Linde, D. Monrad, D. Stroook, D. Surgailis and S. Yakowitz. We also thank June Maxwell for editorial assistance, Peggy Ravitch for help with the production of the volume, and Lisa Brooks for secretarial assistance. Finally, we are indebted to Dr. Martin Gilchrist, the Statistics editor, and the Springer editorial board for their excellent cooperation and enthusiastic support throughout this project."

Professor Herbert A. David of Iowa State University will be turning 70 on December 19, 1995. He is reaching this milestone in life with a very distinguished career as a statistician, educator and administrator. We are bringing out this volume in his honor to celebrate this occasion and to recognize his contributions to order statistics, biostatistics and design of experiments, among others; and to the statistical profession in general. With great admiration, respect and pleasure we dedicate this festschrift to Professor Herbert A. David, also known as Herb and H.A. among his friends, colleagues and students. When we began this project in Autumn 1993 and contacted potential contributors from the above group, the enthu siasm was phenomenal. The culmination of this collective endeavor is this volume that is being dedicated to him to celebrate his upcoming birthday. Several individuals have contributed in various capacities to the success ful completion of this project. We sincerely thank the authors of the papers appearing here. Without their dedicated work, we would just have this pref ace Many of them have served as (anonymous) referees as well. In addition, we are thankful to the following colleagues for their time and advice: John Bunge (Cornell), Z. Govindarajulu (Kentucky), John Klein (Medical U."

The first edition of Theory of Rank Tests (1967) has been the precursor to a unified and theoretically motivated treatise of the basic theory of tests based on ranks of the sample observations. For more than 25 years, it helped raise a generation of statisticians in cultivating their theoretical research in this fertile area, as well as in using these tools in their application oriented research. The present edition not only aims to revive this classical text by updating the findings but also by incorporating several other important areas which were either not properly developed before 1965 or have gone through an evolutionary development during the past 30 years. This edition therefore aims to fulfill the needs of academic as well as professional statisticians who want to pursue nonparametrics in their academic projects, consultation, and applied research works.
Key Features
* Asymptotic Methods
* Nonparametrics
* Convergence of Probability Measures
* Statistical Inference