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The present research work is to design and evaluate an oral time
dependent, pulsatile drug delivery system containing Salbutamol
Sulphate, which can be targeted to time dependent manner, to
modulate the drug level in synchrony with the circadian rhythm of
nocturnal asthma. A time dependent pulsatile dosage form was
developed by using a various grade of HPC in compressed coated
layer. A pulsatile 'Tablet in Tablet' dosage form, taken at bed
time with a programmed start of drug release early in morning
hours, can prevent a sharp increase in the incidence of asthmatic
attacks, during the early morning hours (nocturnal asthma), a time
when the risk of asthmatic attacks is the greatest.
The objective of this study is to develop controlled porosity
osmotic pump tablet of Verapamil Hydrochloride, which is an
antihypertensive candidate, using Polyethylene glycol (PEG) 400 as
pore former in Cellulose acetate semipermeable membrane and
Mannitol as a osmotic agent which release drug for extended period
of time (24 h) and drug release of optimized formulation is
independent of pH and agitation speed with zero order release.
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