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Molecular design software is software deals with molecular
modeling, that provides special support for developing molecular
models de novo. In contrast to the usual molecular modeling
programs such as the molecular dynamics and quantum chemistry
programs, such software directly supports the aspects related to
the construction of molecular models: Molecular graphics
interactive molecular drawing and conformational editing building
of polymeric molecules, crystals and solvated systems partial
charges development geometry optimization support for the different
aspects of Force Field development
HERBAL medicine is still the mainstay of about 75-80% of the world
population, mainly in the developing countries, for primary health
care because of better cultural acceptability, better compatibility
with the human body and lesser side effects. However, the last few
years have seen a major increase in their use in the developed
world. In Germany and France, many herbs and herbal extracts are
used as prescription drugs and their sales in the countries of
European Union were around $ 6 billion in 1991 and may be over $ 20
billion now. In USA, herbal drugs are currently sold in health food
stores with a turnover of about $ 4 billion in 1996 which is
anticipated to double by the turn of the century1. In India, the
herbal drug market is about $ one billion and the export of
plant-based crude drugs is around $ 80 million2 . Herbal medicines
also find market as nutraceuticals (health foods) whose current
market is estimated at about $ 80-250 billion in USA and also in
Europe.
A generic drug (generic drugs, short: generics) is a drug which is
produced and distributed without patent protection. The generic
drug may still have a patent on the formulation but not on the
active ingredient. A generic must contain the same active
ingredients as the original formulation. According to the U.S. Food
and Drug Administration (FDA), generic drugs are identical or
bioequivalent to the brand name counterpart with respect to
pharmacokinetic and pharmacodynamic properties. By extension,
therefore, generics are identical in dose, strength, route of
administration, safety, efficacy, and intended use. In most cases,
generic products are available once the patent protections afforded
to the original developer have expired. When generic products
become available, the market competition often leads to
substantially lower prices for both the original brand name product
and the generic forms. The time it takes a generic drug to appear
on the market varies.
Tablet is the most popular among all dosage forms existing today
because of its convenience of self administration, compactness and
easy manufacturing; however hand tremors, dysphasia in case of
geriatric patients, the underdeveloped muscular and nervous systems
in young individuals and h case of uncooperative patients, the
problem of swallowing is common phenomenon which leads to poor
patient compliance To overcome these drawbacks, mouth dissolving
tablets (MDT) or orally disintegrating tablets; (ODT) has emerged
as alternative oral dosage forms. These are novel types; of tablets
that disintegrate/dissolve/ disperse in saliva within few seconds'.
According to European Pharmacopoeia, the ODT should
disperse/disintegrate in less than three minutes. The basic
approach used in development of MDT is the use of
superdisintegrants like Cross linked carboxymelhylcellulose
(Croscarmeliose), Sodium starch glycol ate (Primogel, Explotab).
Polyvinylpyrrolidone (Polyplasdone) etc. which provide
instantaneous disintegration of tablet after putting on tongue,
thereby releasing the drug in saliva.
Information technology provides several databases, data analysis
tools, and knowledge extraction techniques in almost every facet of
life. In pharmaceutical sciences, several successful attempts are
being made under the umbrella of pharmacoinformatics (synonymously
referred to as pharmainformatics).Chemoinformatics and
bioinformatics contribute directly to drug discovery through
virtual screening. Topics like neuroinformatics, immunoinformatics,
vaccine informatics, and biosystem informatics contribute
indirectly by providing necessary inputs for pharmaceutical design
in this area. Topics like metabolomics, toxicoinformatics, and ADME
informatics arecontributing to this fi eld by providing information
regarding the fate of a NCE/lead in vitro and in vivo
conditions.The integration of back - end technologies (for storing
and representing chemical structure and chemical libraries) and
front - end technologies opportunities in chemoinformatics.
The calibration system provides accurate results with a minimum of
effort. However, a poorly constructed system can waste valuable
instrument and analyst time, and result in poor quality data. This
book will provide a complete set of instructions on how to set up
and evaluate any analytical system, and equipments with an emphasis
on providing the highest quality results with a minimum of effort.
This book provides valuable and practical information that is not
currently available from any other single reference source.
Students/Research scholar will learn: The fundamentals of linear
regression Different options for preparing data What calibration
options are available Why the correlation coefficient is not a good
measure of calibration quality Simple procedures and tests for
evaluating calibration data
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