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Repimelts and Its Special Perspectives (Paperback)
Loot Price: R1,547
Discovery Miles 15 470
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Repimelts and Its Special Perspectives (Paperback)
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Tablet is the most popular among all dosage forms existing today
because of its convenience of self administration, compactness and
easy manufacturing; however hand tremors, dysphasia in case of
geriatric patients, the underdeveloped muscular and nervous systems
in young individuals and h case of uncooperative patients, the
problem of swallowing is common phenomenon which leads to poor
patient compliance To overcome these drawbacks, mouth dissolving
tablets (MDT) or orally disintegrating tablets; (ODT) has emerged
as alternative oral dosage forms. These are novel types; of tablets
that disintegrate/dissolve/ disperse in saliva within few seconds'.
According to European Pharmacopoeia, the ODT should
disperse/disintegrate in less than three minutes. The basic
approach used in development of MDT is the use of
superdisintegrants like Cross linked carboxymelhylcellulose
(Croscarmeliose), Sodium starch glycol ate (Primogel, Explotab).
Polyvinylpyrrolidone (Polyplasdone) etc. which provide
instantaneous disintegration of tablet after putting on tongue,
thereby releasing the drug in saliva.
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