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Since its inception 14 years ago, CAPRISA has conducted numerous
clinical studies that have influenced international TB-HIV
treatment guidelines as well as HIV prevention through innovations
in the microbicide and vaccine fields. This book provides a
historical account of how each of CAPRISA's high impact studies was
created, developed, implemented, analysed and communicated. In
doing so, the reader is taken on a journey that provides glimpses
into the genesis of research ideas and how this ultimately leads to
a range of HIV prevention and treatment studies that have impacted
the global response to the HIV and TB epidemics. Comprised of 5
sections, the book details the following: HIV epidemic in South
Africa and the establishment of a research centre to undertake
clinical, epidemiological and laboratory research on HIV. CAPRISA's
clinical trials on HIV and HSV-2 prevention. These studies
investigated the impact of tenofovir gel as topical antiretroviral
pre-exposure prophylaxis (PrEP), implementation of topical PrEP
through family planning clinics, conditional cash incentives for
HIV prevention, HIV vaccines, and passive immunisation with broadly
neutralising antibodies. CAPRISA's research on the treatment of HIV
and TB co-infection. A review of the major scientific findings from
the CAPRISA studies on acute infection and genital mucosal
immunology. Essential support activities for the conduct of
clinical trials, including research laboratories and pharmacies, as
well as establishing effective communication and sustainable
structures for community engagement to maintain effective and
respectful partnerships with participating communities. The book
concludes with a chapter about the challenges facing future HIV
prevention and treatment trials. The CAPRISA Clinical Trials: HIV
Treatment and Prevention is a resource for undergraduate and
postgraduate students, health care providers, doctors,
decision-makers and researchers who are seeking guidance and
insights on clinical trials - their creation, conduct and impact.
Since its inception 14 years ago, CAPRISA has conducted numerous
clinical studies that have influenced international TB-HIV
treatment guidelines as well as HIV prevention through innovations
in the microbicide and vaccine fields. This book provides a
historical account of how each of CAPRISA's high impact studies was
created, developed, implemented, analysed and communicated. In
doing so, the reader is taken on a journey that provides glimpses
into the genesis of research ideas and how this ultimately leads to
a range of HIV prevention and treatment studies that have impacted
the global response to the HIV and TB epidemics. Comprised of 5
sections, the book details the following: HIV epidemic in South
Africa and the establishment of a research centre to undertake
clinical, epidemiological and laboratory research on HIV. CAPRISA's
clinical trials on HIV and HSV-2 prevention. These studies
investigated the impact of tenofovir gel as topical antiretroviral
pre-exposure prophylaxis (PrEP), implementation of topical PrEP
through family planning clinics, conditional cash incentives for
HIV prevention, HIV vaccines, and passive immunisation with broadly
neutralising antibodies. CAPRISA's research on the treatment of HIV
and TB co-infection. A review of the major scientific findings from
the CAPRISA studies on acute infection and genital mucosal
immunology. Essential support activities for the conduct of
clinical trials, including research laboratories and pharmacies, as
well as establishing effective communication and sustainable
structures for community engagement to maintain effective and
respectful partnerships with participating communities. The book
concludes with a chapter about the challenges facing future HIV
prevention and treatment trials. The CAPRISA Clinical Trials: HIV
Treatment and Prevention is a resource for undergraduate and
postgraduate students, health care providers, doctors,
decision-makers and researchers who are seeking guidance and
insights on clinical trials - their creation, conduct and impact.
The Oxford Textbook of Global Public Health is the ultimate
resource on the subject of public health and epidemiology. It
offers a global and comprehensive perspective on wide-ranging
public health needs and priorities in modern health care.
Thoroughly revised and updated for the seventh edition, the book is
split into three main topics. 'The Scope of Public Health' covers
the development of the discipline, determinants of health and
disease, and policies, law, and ethics. The second volume focuses
on The Methods of Public Health, including the science of
epidemiology, social science techniques, and environmental
techniques. Finally, The Practice of Public Health is fully
explored, with sections on specific public health problems, ways of
prevention and control, the varying needs of different populations,
and the functions of public health services and professionals.
Three new editors have joined for this edition, Liming Li (China),
Fran Baum (Australia), and Alastair H Leyland (UK), complimenting
Quarraisha Abdool Karim (South Africa) and Roger Detels (USA), for
a truly global perspective on public health. Featuring over 225
contributors from countries all over the world ensures that the
book covers public health from all aspects, with vastly different
health systems and priorities. Featuring new chapters on gender
identity and gender-based violence, environmental health and
climate change, genomics and epidemiology, and emerging and
re-emerging infectious diseases, the seventh edition of the Oxford
Textbook of Global Public Health remains the most comprehensive
text on the subject and is a vital resource for public health
practitioners and trainees, clinical epidemiologists, and students
in the field.
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