Nicotinic Acetylcholine Receptors in Health and Disease provides the latest information Nicotinic acetylcholine receptors (nAChRs), which are involved in numerous diseases, including Alzheimer's, Parkinson's, and schizophrenia, and are important potential translational targets for treatment of these diseases, as well as therapy for addiction. This book focuses on the roles and function of nAChRs inside and outside of the nervous system, with an emphasis on translational implications and future prospects for the treatment of numerous disorders. This greater understanding of the basic neurobiology and clinical roles of nAChRs provides important insights for future clinical treatments of many major disorders.

The author approaches the subject of wine from the standpoint of its Medical, Scientific, Historical, Sensory, Cultural, and Health viewpoints. He tells you the "Why," as well as the "What." The book is a well-organized collage of essays written on the numerous subjects in the world of wine, food, and health. The book starts from the basics, through the components and what influences them, Wine defects, how and why you taste and why you like what you like, the various wines, various wine tools, and then moves to pairing with food, wine service, and finally the health benefits and risks of wine consumption. One chapter is guest-written by Tim Hanni, MW, a Master of Wine from California.

Fast cars, law men, moonshine, romance in the cotton fields, and wild cat whiskey It was Garden City, Alabama the spring of 1946. Boys were coming home. World War II was over. Many mothers were learning that their sons would not be coming home. Garden City was beginning to settle back in to a nice easy routine. Mr. Sam the local merchant was getting in his sugar orders for the season. The farmers were looking for good crops, and the moonshiners, were looking forward to make good on their orders. A certain revenuer from DC was poking around town. He was trying his best to find out about this "special shine" that everyone was talking about. Cracker Black, the brains behind the operation has a 50 gallon pot making moonshine for a local man named Hollis. Now Hollis is a nefarious character ran several juke joints out on 78 hwy on the strip. When word got round to Cracker his shine was wanted in Memphis and St Louis he had to ramp up the production. He hires two black fellers Big George and Little Willie right out the cotton patch. They are able to work at night in the woods and not be seen by the law because of them being black. When the sleepy little town's folk turn off their lights for the night, the moonshiners go to work making that good old Alabama Shine. Life was good, again.....

This issue of Hematology/Oncology Clinics, guest edited by Ravi A. Chandra, Lisa A. Kachnic, and Charles R. Thomas, Jr., is the second volume of Contemporary Topics in Radiation Medicine, with focus on Disease Sites. This issue is one of six selected each year by our series consulting editors, Dr. George P. Canellos and Dr. Edward J. Benz. Topics discussed in this issue will include: Breast, Central Nervous System, GI, Genitourinary/Prostate, Gynecologic, Head & Neck, Thoracic, Hematologic cancers (including Leukemias, Lymphomas), Pediatric Cancer, Sarcoma/STS, Skin, Oligometastatic Disease, Palliation & Supportive Care & Inpatient Medicine, Radiation Emergencies, among others.

This issue of Hematology/Oncology Clinics, Guest Edited by Drs. Ravi A. Chandra, Lisa A. Kachnic, Charles R. Thomas, Jr., is part one of a two-part issue focused on Contemporary Topics in Radiation Medicine. Topics include, but are not limited to, Basic Medical Physics, Basic Radiobiology, Modern Radiation Treatment Planning & Delivery, Advanced Imaging Techniques in Diagnosis and Tx, Particle Therapy/Protons, SRS/SBRT, Modern Brachytherapy, Immunotherapy/Abscopal, Nanotechnology, Bioinformatics & Artificial Intelligence, Quality-of-life & Outcomes, Normal Tissue Issues and Toxicity, Radiation Modifiers, and Health Economics/Disparities.

This book aims to provide insight into the fields of business and leadership by examining the role of ethics in these areas. The papers in this book derive from the 2014 Annual Griffiths School of Management International Conference, organized by Emanuel University of Oradea, Romania, where academics and practitioners interacted and discussed current insights and research in the different dimensions of business ethics and leadership. This resulting book offers empirical and theological research on ethics, business and leadership from a transdisciplinary and knowledge- based context. Since the financial crisis in 2008, the debate on business ethics and leadership has dominated the public sphere at all levels of interest, from grassroots to the elites in educational institutions, governments, businesses and NGOs. Naturally, constructive and transdisciplinary discussions need to take place, with due consideration for the specific context of each situation, so that propositions upon which to build the future can be formulated. These discussions unfold in an ever more intricate world of business, powered by ever more pervasive and intelligent technology and scientific development, all brought together by globalization. In this world, organizations are faced with new and more complex ethical issues in their pursuit to serve clients, gain profits, motivate employees, collaborate with partners and act responsibly towards society and the environment. A wise approach to changing the future is to understand the mistakes of the past, because one must always learn how to overcome past mistakes in order to develop a better future. But a necessary approach to building a better future is looking at the world through a transdisciplinary mindset. This allows us to see the world as a complex whole; it fosters creative interaction between fields of knowledge; it opens doors for knowledge and innovation flows across disciplines; and it allows the tackling of complex problems and situations. Given the current context of our world, this is an approach that we ought to pursue. Featuring contributions from academics, researchers, scholars and practitioners from across the globe, this book will be of great interest for students and practitioners in the fields of business, leadership and ethics.

This book explores the increased necessity of organizations to encourage human talent in the globalized economy, with particular emphasis on the impact in Eastern Europe. Featuring contributions presented at the 7th Annual Griffiths School of Management International Conference on Business and Ethics (GSMAC) organized by Emanuel University of Oradea, this book presents in-depth analysis of the economic, social and religious implications of the transition from low cost of labor to increased human talent in Eastern Europe and offers multiple theoretical and practical solutions. In 2004, Klaus Schwab, president and founder of the World Economic Forum, stated that the old era of capitalism and socialism is being replaced by a new era of "talentalism". The true competitive advantage of organizations and nations is increasingly becoming human talent, defined as the ability to "have new ideas that have value". Nations and organizations are exploring ways to reform their education systems and organizational structures in order to train, foster and encourage human talent. In Eastern Europe since the fall of communism in 1989, the competitive advantage of the region has been low cost of labor. However, since the integration within the European Union, millions of Eastern Europeans have left their home countries rendering the "low-wage competitive advantage" almost obsolete. In addition, the migration of able-working individuals has left behind mainly children and pensioners, placing a disproportionately heavy burden upon public and government services. It is within this context that the contents of this book explore the impact of the increased need of high human talent on Eastern European countries. Featuring contributions around topics such as poverty, healthcare management, cross-border cooperation, education systems, and religious influence on economic development, this book will be of interest of scholars, researchers, students and policy-makers interested in the business development and economic growth of Eastern Europe.

Antisocial behaviors including bullying, violence, and aggression have been an area of intense interest among researchers, clinicians, policy makers, and the general public because of their grievous consequences on individuals and society. Our understanding of the origins and development of these behaviors in individuals has recently progressed with the application of new scientific advancements and technologies such as neuroimaging, genomics, and research methods that capture behavioral changes in the first few years of life.
The Origins of Antisocial Behavior: A Developmental Perspective provides an overview of the recent research on the development of antisocial behavior and synthesizes this information to inform readers not only of the risks, but also how they interact, to result in antisocial and aggressive behavior. The volume is divided into three sections: advances in neuroscience, advances in behavioral and clinical research, and legal and policy implications. Specific topics include genetic markers and aggressive behavior, the use of fMRI to track adolescent brain development, the role of peer influences on aggression, parenting and temperament, screening tools for diagnosing antisocial behavior in toddlers and adolescents, and how new research will influence interventions, policy, and future study. Experts from genetics, neuroimaging, and developmental science discuss the insights these scientific approaches have provided in understanding how nature and the environment interact in the emergence of antisocial behavior. The Origins of Antisocial Behavior is an important and unique resource that will be of use to developmental scientists, mental health professionals, and policymakers involved in the juvenile justice system.

This issue of Rheumatic Disease Clinics of North America provides foundational and in-depth information about paraneoplastic and cancer treatment-related rheumatic disorders, in which every practicing rheumatologist should be well-versed.? Topics covered include neoplasm risk in patients with rheumatic diseases; neoplasm risk of anti-rheumatic therapy; rheumatologic laboratory findings in malignancy; rheumatic manifestations of primary and metastatic bone tumors and paraneoplastic bone disease; neoplastic/paraneoplastic synovitis; neoplastic/paraneoplastic dermatitis, fasciitis, and panniculitis; neoplastic/paraneoplastic vasculitis, vasculopathy, and hypercoagulability; neoplastic/paraneoplastic myalgias and myositis; and less-common neoplastic/paraneoplastic syndromes.

Romania stands at the crossroads of Europe, Asia, and the Middle East. Since 1990, when the country experienced the bloodiest revolution of all of the Warsaw Pact members, Romania has gone through withering change. While the formal transition from a totalitarian, communist state was completed in 2007 with Romania's accession into the European Union, the adaptation of the nation's people and business climate to a market-based economy is a daily occurrence. In the 2000's, in the lead up to EU accession, Romania was one of the largest recipients of Foreign Direct Investment in the world. While multinational corporations poured in hundreds of billions of dollars, there was also a restructuring of the way business was conducted. Western systems of management and organization-foreign to most Romanian academics and business people-almost overnight transformed the way the marketplace was perceived. Romania's entrepreneurs were quick to adapt to the new ways, leveraging new opportunities in the environment. Fortunes were made. Multinationals also burgeoned in Romania. Companies like Microsoft, General Electric, Timken, Kraft, P&G, Renault and dozens of others successfully took advantage of the possibilities created by a relatively well-educated population that was moving into the middle class. For the most part, however, researchers and scholars were caught off guard by the quickening pace of business change in Romania. Only until very recently has the academic community at large been able to wade through the murkiness and begin to see what the new landscape looks like. It is the purpose of this edited volume, which includes the work of some of Romania's finest business scholars, to provide even greater clarity to the current and future scene. Moreover, the experience in Romania helps shed light on the dynamics of economic and business transition throughout Eastern Europe, the Middle East, and other emerging regions, with implications for practice, policymaking, and research.

In this probing critique of aviation security since 9/11, Andrew R. Thomas, a globally recognized aviation security expert, examines the recent overhaul of the national aviation security system.
Despite the complete federal takeover of aviation security in November 2001, Thomas notes many continuing problems, including: millions of passenger bags that are still not screened or matched; the unresolved problem of air rage and unruly passenger behavior; the "forgotten chasm" of air cargo, which remains largely unchecked due to inadequate resources; and lax standards, the hiring of high-risk employees, and the failure to secure critical areas in many of our nation's airports.
Thomas also considers many of the proposed solutions to these vulnerabilities: biometrics, profiling, air marshals, bomb-detection devices, and smart technology that links reservations systems to private and government databases. How practical are these proposals? Will they work? What will they cost? How much time will be needed to implement any or all of them? In light of the restructuring of airline security, what new roles will be played by the airline industry, government, airports, and the Transportation Security Administration? Thomas's thorough analysis and command of all the facts create an enlightening overview of the airline security dilemma and its numerous formidable challenges.
Finally, he considers the future, outlining a strategic approach for government and industry to meet new and existing threats while continuing to serve the public in an efficient manner.

In the last few years, several planes have almost gone down because of the aberrant or abusive behavior of one or more individuals. Unfortunately, such outbursts are becoming increasingly common. These dangerous actions -known as air rage - are by far the greatest threat to the safety and security of the 1.5 billion passengers who travel annually by air. Although the number of air-rage cases continues to rise, airlines, airports, and even governmental agencies consistently underreport the scope of the problem, thus exacerbating an already volatile situation.
This intensively researched book by an anonymous veteran insider of the airline industry and an experienced investigative journalist provides reliable, detailed research never before reported. The book fully explores the fundamental causes of air rage: alcohol and illegal drug abuse, mental illness, overcrowded airplanes, the economic realities of the airline business, the failure to report air-rage incidents, and the lack of consequences for perpetrators. Each point is illustrated through recounting actual air-rage incidents that the authors have collected from interviews with flight crews and passengers and/or through their Web site at www.AirRage.org.
Without being alarmist in tone, this important book will make readers aware of the scope and magnitude of the air-rage problem and what might be done to solve this emerging crisis in the skies.
See also Andrew Thomas's Aviation Insecurity: The New Challenges of Air Travel.

What makes a great boss? Bosses don't become great because of their title, rank, degree of authority, office size, or benefits package. Great bosses aren't even necessarily great managers. Instead, they possess a set of core competencies that set them apart from mere managers. The skill set of great bosses entails five qualities: they do the right thing for the right reason; they never make the same mistake twice; they set their personal expectations higher than those of their bosses; they go to their bosses with action plans, not problems; and they follow up. If a boss has only one of these characteristics, he or she is probably very successful. But application of all five defines what it means to be a great boss, to be successful in good times and bad, through change and adversity, and to be recognized as such by the people you work for-as well as by the people who work for you.

The future success of many companies in the United States and Europe is becoming more dependent on effectively developing and expanding markets in new emerging and partially developed countries. Few companies, however, know how to do it well, if at all. Their success rate is low, while the cost of failure remains high. Caslione and Thomas provide insights, knowledge, special tools, and the experience that will show executives how to take hold of these challenges. Through case studies of companies in a wide cross-section of industries, the authors highlight the processes necessary to develop successful market entry, sales, and distribution strategies for their companies in emerging markets around the world.

Global business strategy can no longer be focused on only one country or region; the risks are too great. Only when a truly global company develops a holistic and global perspective and implements proven strategies can the success in the new global economy be achieved.

At its core, accountability is the responsibility to act. It is the commitment to do the right thing and stand by your decisions. Perhaps most importantly, it is a quality that must come from within; dishearteningly, even as legislators, shareholders, customers, and community activists are demanding greater accountability from corporate leaders, too many are waiting for some third party to take action. Whatever the endeavor, it is ultimately the individual who must hold himself to the highest standard first. Those who manage by accountability viscerally know that external rules cannot substitute for character. And they know that accountability is a quality that can be developed, honed through practice, and encouraged in others. Using stories drawn from David Dealy's experiences on the front lines, as well as examples from other successful leaders, Managing by Accountability demonstrates how leaders who embark on a management philosophy of personal accountability imbue their organizations with the qualities of integrity and responsibility. In their down-to-earth style, the authors identify the five great accountability mistakes and offer a wealth of practical suggestions for overcoming them to achieve outstanding results throughout the organization. In some cases it may be Congress (e.g., Sarbanes-Oxley legislation), the media, the company's legal or communications department, Wall Street, disgruntled customers, or angry community activists. This is not to say that formal accountability programs are useless; they do play an important role. Nevertheless, it is ultimately the individual who must hold himself to the highest standard first—without waiting to be told, pushed, or prodded. Those who manage by accountability viscerally know that external rules cannot substitute for character. And they also know that accountability can be developed, honed through practice, and encouraged in others. Managing by Accountability demonstrates how leaders who embark on a management philosophy of personal accountability imbue their organizations with the qualities of integrity and responsibility. Using stories drawn from David Dealy's experiences on the front lines, as well as examples from other successful leaders, the book provides concrete examples of accountability in action. In their down-to-earth style, Dealy and Thomas identify the five great accountability mistakes and offer a wealth of practical suggestions for overcoming them to achieve outstanding results throughout the organization.

This book provides an important picture of India's nuclear intentions and capabilities at the beginning of the 21st century. Academic and governmental experts from both the United States and India explore the strategic, technological, military and economic dimensions of India's nuclear world. The contributors bring their expertise together in an unusual mix of viewpoints from three continents on the several dimensions of a nuclear India at the turn of the century. It is an important resource in the United States to help policymakers respond to the regional and global proliferation problems that have resulted from India and Pakistan's nuclear tests of 1998. It is an important aid to India in exploring and evaluating its nuclear strategy and the political, economic and military consequences of its nuclear decisions.