The ribosome is a macromolecular machine that synthesizes proteins with a high degree of speed and accuracy. Our present understanding of its structure, function and dynamics is the result of six decades of research. This book collects over 40 articles based on the talks presented at the 2010 Ribosome Meeting, held in Orvieto, Italy, covering all facets of the structure and function of the ribosome. New high-resolution crystal structures of functional ribosome complexes and cryo-EM structures of translating ribosomes are presented, while partial reactions of translation are examined in structural and mechanistic detail, featuring translocation as a most dynamic process. Mechanisms of initiation, both in bacterial and eukaryotic systems, translation termination, and novel details of the functions of the respective factors are described. Structure and interactions of the nascent peptide within, and emerging from, the ribosomal peptide exit tunnel are addressed in several articles. Structural and single-molecule studies reveal a picture of the ribosome exhibiting the energy landscape of a processive Brownian machine. The collection provides up-to-date reviews which will serve as a source of essential information for years to come.

The biological world operates on a multitude of scales - from molecules to cells to tissues to organisms to ecosystems. Throughout all these levels runs a common thread: the communication and onward passage of information - from cell to cell, from organism to organism and, ultimately, from generation to generation. But how does this information - no more than a static repository of data - come alive to govern the processes that constitute life? The answer lies in the concerted action of molecular components which cooperate through a series of carefully-regulated processes to bring the information in our genome to life. These components and processes lie at the heart of one of the most fascinating subjects to engage the minds of scientists today: molecular biology. Molecular Biology: Principles of Genome Function offers a fresh, distinctive approach to the teaching of molecular biology. It is an approach that reflects the challenge of teaching a subject that is in many ways unrecognizable from the molecular biology of the 20th century - a discipline in which our understanding has advanced immeasurably, but about which many questions remain to be answered. It is written with several guiding themes in mind: - A focus on key principles provides a robust conceptual framework on which students can build a solid understanding of the discipline; - An emphasis on the commonalities that exist between the three kingdoms of life, and the discussion of differences between the three kingdoms where such differences offer instructive insights into molecular processes and components, gives students an accurate depiction of our current understanding of the conserved nature of molecular biology, and the differences that underpin biological diversity; - An integrated approach demonstrates how certain molecular phenomena have diverse impacts on genome function by presenting them as themes that recur throughout the book, rather than as artificially separated topics At heart, molecular biology is an experimental science, and a central element to the understanding of molecular biology is an appreciation of the approaches taken to yield the information from which concepts and principles are deduced. Yet there is also the challenge of introducing the experimental evidence in a way that students can readily comprehend. Molecular Biology responds to this challenge with Experimental Approach panels, which branch off from the text in a clearly-signposted way. These panels describe pieces of research that have been undertaken, and which have been particularly valuable in elucidating different aspects of molecular biology. Each panel is carefully cross-referenced to the discussion of key molecular biology tools and techniques, which are presented in a dedicated chapter at the end of the book. Beyond this, Molecular Biology further enriches the learning experience with full-colour, custom-drawn artwork; end-of-chapter questions and summaries; relevant suggested further readings grouped by topic; and an extensive glossary of key terms. Among the students being taught today are the molecular biologists of tomorrow; these individuals will be in a position to ask fascinating questions about fields whose complexity and sophistication become more apparent with each year that passes. Molecular Biology: Principles of Genome Function is the perfect introduction to this challenging, dynamic, but ultimately fascinating discipline.

A sturdy keyboard attached to a book of well-known tunes, with colour-coded notes so that anyone can play them. Tunes include Twinkle, Twinkle, Frere Jacques, Ode to Joy and Row, Row, Row your Boat and there are ideas for making up simple tunes too. Each note is represented by a colour that corresponds to the same colour on the keyboard, so even very young children can pick out the tunes. With delightful illustrations, this is a lovely gift that can be taken anywhere.

Sixty-odd poems about writing, about words, about plotting and drafting, about editing and publishing, about the trials and successes of the publishing world. Written by a published English novelist of urban fantasy and erotica.

A collection of the first five titles in the Coming Together: Neat line of erotic novellas. CONTENTS: Dealing with Isabella (Jenna Byrnes); Ryder's Mate (Wendy Stone); Tangled Roots (Giselle Renarde); Leget's Despair (Rachel Green); The Six Swans (Annabeth Leong) Proceeds from the sales of Coming Together: Neat publications benefit Kiva (kiva.org) Reviews posted at the point of sale are very much appreciated, as are blog posts, tweets (@Coming_Together), and social networking updates. Every little bit helps Coming Together sell more books and raise more money for charity Thank you for supporting erotic altruism. NOTE: This purchase also entitles you to a digital (ebook) copy of this title. Simply forward your receipt to the publisher via the email address below, and a ZIPped file containing PDF, EPUB, MOBI, and LIT formats will be attached and returned. Publisher: Coming Together (erotic.cocktail at] gmail dot] com)

A Catholic priest and a pagan priestess come together to solve the murder of a sex-guru. Pagan priestess Meinwen Jones moves 300 miles to meet up with a man who turns up dead. She's approached by Father Brande, who needs her help to uncover the dead man's secrets. Why did he have so many women around him, and why do they all have matching tattoos? Just who was having an affair with the old lady who hung herself, and when will the priest stop putting out Meinwen's ritual fires? Content Warning: BDSM, Erotic pain and violence, polyamory and murder.

141 long and short-form poems about the life of an English novelist and her daily walks with three dogs, her memories of rural England and the life of a writer.