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Topical and transdermal drug delivery systems (TDDs) have several
advantages over traditional drug delivery methods, as they can be
less invasive, more sanitary, more cost-effective, and may result
in better patient compliance. TDDs play a significant role in
therapeutics with a variety of preparations and approaches designed
by expert formulation scientists. This volume integrates a wide
variety of case studies, research, and theories to reveal their
diversity and capture the novel approaches of transdermal and
topical drug delivery employed by developers and content experts in
the field. It provides an abundance of important information and
state-of-the-art research on topical and transdermal drug delivery
systems and addresses the basics of drug delivery systems,
strategies to enhance permeation across membranes, and formulation
and evaluation of diverse dosage forms. The volume presents an
evaluation of the pros and cons of conventional drug delivery
systems against TDDs and discusses the nuances of micro- and
nano-systems in TDDs. The extraordinary packages of nano systems
(vesicular systems, polymeric nanoparticles, nanoemulsion and
dendrimers) are broadly discussed, and their applications are
reviewed through a transdermal route. The book looks at TDDs and
the main nanoparticles used in skin diseases and lesions of the
aging, such as psoriasis, vitiligo, cancer, lesions of the aging
and others. Chapters also discuss polymeric micelles in topical and
transdermal delivery; microneedles; emulsion, nanoemulsion and
microemulsion; TDDs in pulmonary drug delivery systems;
nanoencapsulated nasal drug delivery systems; skin sensitivity and
irritation testing for transposing transdermal drug delivery
systems; and regulatory aspects of drug development for dermal
products. Topical and Transdermal Drug Delivery Systems:
Applications and Prospects will be a valuable resource for
pharmaceutical scientists and researchers, industry professionals,
and academicians and students of the pharmaceutical and biomedical
sciences.
Covers the applications and implications of nutraceuticals in
cancers, including prostate cancer lung cancer, breast cancer, skin
cancer, colon cancer, liver cancer, cervical cancer Discusses the
principles of nanotechnology in the delivery of nutraceuticals for
the prevention and treatment of cancer Explores the role of
antioxidants, flavonoids, and phytochemicals in cancer prevention
The unique volume, COVID-19 and Immunomodulation with Special
Emphasis on Nutraceutical and Herbal Formulation, covers recent
advances in the management, prevention, and application of
nutraceuticals and herbs in preventing and treating COVID-19. It
demonstrates the beneficial immunomodulatory properties of
nutraceuticals, spices, polyphenols, customary (traditional)
medications, natural products, ayurveda, antioxidants, trace
elements, vitamins, vaccines, etc., for COVID-19. Key features:
Evaluates the benefits of herbal immunomodulators for safety and
having fewer (if any) side effects, as opposed to
conventional/artificial drugs Considers the role of ayurvedic
medicines in the control and prevention of COVID-19 viruses
Summarizes the most current discoveries and key factors of
SARS-CoV-2 genetics, pathophysiology, and the host immune response
Looks at the efficacy of vaccines against COVID-19 infection and
the vaccines currently available Explains the pharmacological
results alongside precise immunomodulator agents, like
immunostimulators and immunosuppressants Looks at the containment
and prevention strategies for COVID-19 infection and offers
strategies for the future The information provided here details how
the use of selected nutraceuticals and herbals can be helpful,
similarly to pharmacological remedies, in stopping some
COVID-19-associated complications in infected patients. It will be
a valuable resource for researchers in pharmaceutical science,
medicine, COVID and related diseases, and others.
This new book discusses the physiological factors that contribute
to metabolic syndrome within the human body and spotlights the
beneficial effects on the body of nutraceuticals and functional
ingredients, botanicals and natural dietary supplements,
structurally numerous antioxidants, B-vitamins, and diverse amino
acids and vital nutrients. The book considers the need to preserve
a balance between energy delivery and strength expenditure that is
essential for maintaining an appropriate body mass index (BMI),
which can contribute to less obesity and fewer metabolic disorders,
such as diabetes type II, cardiovascular illnesses, etc. The
authors present recent research that proves that proper
vitamins—including antioxidants, nutrients, micronutrients, and
selected amino acids—can enhance the body’s metabolism and
defend it from inflammatory onslaughts.
This new volume on applications and advances in tissue engineering
presents significant, state-of-the-art developments in this
exciting area of research. It highlights some of the most important
applied research on the applications of tissue engineering along
with its different components, specifically different types of
biomaterials. It looks at the various issues involved in tissue
engineering, including smart polymeric biomaterials, gene therapy,
tissue engineering in reconstruction and regeneration of visceral
organs, skin tissue engineering, bone and muscle regeneration, and
applications in tropical medicines. Covering a wide range of issues
in tissue engineering, the volume Provides an overview of the
efficacy of the different biomaterials employed in tissue
engineering (such as skin regeneration, nerve regeneration,
artificial blood vessels, bone regeneration). Looks at smart
polymeric biomaterials in tissue engineering Discusses the hybrid
approach of tissue engineering in conjunction with gene therapy
Explores using tissue engineering in the management of tropical
diseases Considers various skin tissue engineering applications,
including wound healing methods, skin substitutes and other
materials Reports on the use of various biomaterials in bone and
muscle regeneration Describes the use of tissue engineering in
reconstruction and regeneration of visceral organs Covers
polysaccharides and proteins-based hydrogels for tissue engineering
applications Providing an abundance of advanced research and
information, Tissue Engineering: Applications and Advancements will
be a valuable resource for medical researchers, pharmaceutical
manufacturers, healthcare personnel, and academicians.
This new volume, Promising Drug Molecules of Natural Origin,
explores potential beneficial drug substances derived from nature.
It presents the general principles, characteristics, evaluation
techniques, and applications involved in drug molecules from
natural sources, such as plants and marine life. With chapters from
renowned experts from around the world, the chapters in this volume
address the challenges of standardization of herbal medicines,
methods of characterization of natural medicines and
phyto-constituents, and quality control methods for herbal
medicines. Several chapters in the book focus on the evolution of
phyto-constituents in cancer therapeutics, while others deal with
applications for other diseases, such as diabetes and
neuroinflammatory disorders. The volume also specifically reviews
heterocyclic drugs from plants. This volume will be a valuable
resource for faculty and advanced students in pharmaceutics as well
as researchers, scientists, and industry professionals in medicine
and drug development.
This new volume, Herbal Product Development: Formulation and
Applications, addresses some of the challenges that hinder the path
of successful natural products from laboratory to market. Highly
skilled, experienced, and renowned scientists and researchers from
around the globe offer up-to-date information that describes
characteristics of herbs and herbal products, applications,
evaluation techniques, and more. There is also a section dedicated
to alternative medicinal strategies for the treatment and cure of
diverse diseases. Also considered, of course, is the efficacy and
safety of herbal products, which are of major concern. This
valuable volume will be an important addition to the library of
those involved in herbal product development and testing, including
researchers, scientists, academicians, industry professionals, and
students in this area.
This new volume, Nanocarriers for Brain Targeting: Principles and
Applications, covers recent research on brain physiology and the
development of drug delivery systems. It explores a diverse variety
of strategies that can be employed to achieve drug targeting to the
brain. The nanocarriers that are discussed include nanoparticles,
vesicular carriers, carriers having carbon as a core constituent,
dispersed systems, and more. The inherent anatomy and physiology of
the brain renders it different from other organs. The past few
decades have witnessed significant research on brain ailments in
response to a majority of hospitalizations that occur due to
age-related central nervous system disorders. The prevalence of
diverse diseases such as Alzheimer's disease, Parkinson's disease,
amyotrophic lateral sclerosis, multiple sclerosis, HIV-dementia,
etc., affect about 1.5 billion people globally, which is further
anticipated to reach 1.9 billion by the year 2020. Nanocarriers for
drug delivery to the brain are seen as one of the answers to this
growing problem.
This volume addresses efforts to overcome the shortcomings of
conventional dosage forms by exploiting the principles of
nanoscience to deliver drugs for medical treatment. Nanodispersions
are an important aspect because they possess globules/particles in
sizes usually below 1000 nm in which the drug is dispersed in a
continuous medium employing surface-active agents as stabilizers.
With chapters written by experienced scientists and researchers in
the field, this volume provides an abundance of information on
various aspects of nanodispersions for drug delivery. The book is
divided into several sections: nanoemulsions, nanosuspensions, and
diverse dispersed systems. The chapters detail what nanodispersions
have demonstrated in the past and what they are expoected to
continue to do in the future as the technology further evolves. Key
features: * Provides an overview of nanoemulsions for drug delivery
* Introduces the general principles, classification, and methods of
preparation of nanoemulsion-based drug delivery systems * Presents
information relevant to specific routes of applications of
nanoemulsions * Looks at the various aspects of nanosuspensions,
including their formulation components, preparation methods, unique
features, methods of characterization, and applications in various
routes of administration * Explores nanomicellar approaches for
drug delivery * Discusses the preparation, applications, and
clinical considerations of nanogels for drug delivery
Addressing the increasing popularity of nutraceuticals, dietary
supplements, and functional foods, this comprehensive and timely
book presents an abundance of information on herbal products and
their applications. The chapter authors-highly skilled,
experienced, and renowned scientists and researchers from around
the globe-offer up-to-date knowledge on the uses of herbal products
in health management, in cancer treatment, in mental health
therapy, and more. Nutraceuticals and Dietary Supplements: Advances
and Applications begins with an introduction, the nomenclature, and
characteristics of nutraceuticals and goes on to discuss in-depth
applications for specific health issues, including cancer,
diabetes, Alzheimer's disease, alcoholism, and more. It also looks
at the pros and cons as well as the analytical techniques used for
the production of nutraceuticals. Chapters cover market size,
regulatory perspectives, manufacturing, and in silico drug design.
The book incorporates a wide diversity of case studies, research,
and theories pertaining to natural products employed by developers
and content experts in the field.
This volume is a thorough presentation of the state-of-the-art
research and developments in drug delivery systems using
nanotechnology and its applications. The second of this two-volume
set, it addresses the applications of nanotechnology or nano-sized
materials in the medical field and the real-world challenges and
complexities of current drug delivery methodologies and techniques.
This volume includes 11 chapters that focus on the targeting facet
of drug delivery systems. Targeting is a focused maneuver to
achieve the specified goals, including achieving the desired result
and reaching the specific location. Targeting has now been
successfully achieved for several diseases/disorders; however, its
role is noteworthy in cancer treatment where chemotherapy is a main
course of approach. Nanotechnology-based products have great
potential by virtue of their inherent features. This edited book
provides a detailed application of nanotechnology in drug delivery
systems in health care. The book discusses general principles of
drug targeting, material of construction and technological concerns
of nanoparticles, and different drug delivery systems and their
preparation. Taken together, the informative chapters will provide
researchers and scientists as well as faculty and students with
valuable research on the effective use of new approaches in
advanced drug delivery nanosystems. Volume 1 of the two-volume
series is subtitled Novel Drug Carriers. The volumes are available
separately or as a set.
With chapters from highly skilled, experienced, and renowned
scientists and researchers from around the globe, Dendrimers for
Drug Delivery provides an abundance of information on dendrimers
and their applications in the field of drug delivery. The volume
begins with an introduction to dendrimers, summarizing dendrimer
applications and the striking features of dendrimers. It goes on to
present the details of usual properties, structure, classification,
and methods of synthesis, with relevant examples. The toxicity of
dendrimers is also discussed. The chapter authors provide an
exhaustive amount of information about dendrimers and their
biomedical applications, including biocompatibility and toxicity
aspects, a very useful feature. This informative volume will be
valuable resource that will help readers to create products derived
from dendrimers and navigate through the regulatory, manufacturing,
and quality control hurdles. It will be an important resource for
researchers, scientists, upper-level students, and industry
professionals.
This volume, the first of the two-volume Drug Delivery Approaches
and Nanosystems series, presents a full picture of the
state-of-the-art research and development in drug delivery systems
using nanotechnology and its applications. It addresses the
ever-expanding application of nanotechnology or nano-sized
materials in the medical field and the real-world challenges and
complexities of current drug delivery methodologies and techniques.
Many methods of drug delivery systems have been used, but very few
of them have been validated for medical use. A major reason for the
above situation, the editors believe, is the gap between academia
and research, and the gap between academic research and real-time
clinical applications and needs. This volume addresses that gap.
This volume presents 12 chapters that provide information about the
preparation and characterization of nanocomposite materials used in
drug delivery systems; advanced research of carbon nanotubes,
nanocomposite materials, and polymer-clay, ceramics, and silicate
glass-based nanocomposites; and the functionality of graphene
nanocomposites. The book also provides detailed information on the
application of nanotechnology in drug delivery systems in health
care systems and medicine. The book describes how nanostructures
are synthesized and draws attention to wide variety of
nanostructures available for biological research and treatment
applications. This valuable volume provides a wealth of information
that will be valuable to scientists and researchers, faculty, and
students. Volume 2 of the two-volume series is subtitled Drug
Targeting Aspects of Nanotechnology. The volumes are available
separately or as a set.
This new volume focuses on the ever-growing and ever-sophisticated
use of nanobiomaterials in drug delivery. There have been
significant developments in the delivery of the active
pharmaceutical ingredients to target sites, thereby sparing the
normal functioning biological systems from damage, and this volume
highlights some of the most important developments in the field.
The book first provides an overview of nanobiomaterials and then
goes on to report on new developments in drug delivery and
nanotechnology, nanobiomaterials as carriers in cancer therapy, and
the diverse uses of nanobiomaterials. Broken into sections, the
chapters cover: an overview of nanobiomaterials drug delivery and
nanotechnology nanobiomaterials as carriers in cancer therapeutics
diverse uses of nanobiomaterials This volume will be a valuable
resource on drug delivery for pharmaceutical manufacturers,
healthcare personnel, and researchers.
This new volume, Herbal Product Development: Formulation and
Applications, addresses some of the challenges that hinder the path
of successful natural products from laboratory to market. Highly
skilled, experienced, and renowned scientists and researchers from
around the globe offer up-to-date information that describes
characteristics of herbs and herbal products, applications,
evaluation techniques, and more. There is also a section dedicated
to alternative medicinal strategies for the treatment and cure of
diverse diseases. Also considered, of course, is the efficacy and
safety of herbal products, which are of major concern. This
valuable volume will be an important addition to the library of
those involved in herbal product development and testing, including
researchers, scientists, academicians, industry professionals, and
students in this area.
Addressing the increasing popularity of nutraceuticals, dietary
supplements, and functional foods, this comprehensive and timely
book presents an abundance of information on herbal products and
their applications. The chapter authors-highly skilled,
experienced, and renowned scientists and researchers from around
the globe-offer up-to-date knowledge on the uses of herbal products
in health management, in cancer treatment, in mental health
therapy, and more. Nutraceuticals and Dietary Supplements: Advances
and Applications begins with an introduction, the nomenclature, and
characteristics of nutraceuticals and goes on to discuss in-depth
applications for specific health issues, including cancer,
diabetes, Alzheimer's disease, alcoholism, and more. It also looks
at the pros and cons as well as the analytical techniques used for
the production of nutraceuticals. Chapters cover market size,
regulatory perspectives, manufacturing, and in silico drug design.
The book incorporates a wide diversity of case studies, research,
and theories pertaining to natural products employed by developers
and content experts in the field.
This new volume, Promising Drug Molecules of Natural Origin,
explores potential beneficial drug substances derived from nature.
It presents the general principles, characteristics, evaluation
techniques, and applications involved in drug molecules from
natural sources, such as plants and marine life. With chapters from
renowned experts from around the world, the chapters in this volume
address the challenges of standardization of herbal medicines,
methods of characterization of natural medicines and
phyto-constituents, and quality control methods for herbal
medicines. Several chapters in the book focus on the evolution of
phyto-constituents in cancer therapeutics, while others deal with
applications for other diseases, such as diabetes and
neuroinflammatory disorders. The volume also specifically reviews
heterocyclic drugs from plants. This volume will be a valuable
resource for faculty and advanced students in pharmaceutics as well
as researchers, scientists, and industry professionals in medicine
and drug development.
This new two-volume set, Drug Delivery Approaches and Nanosystems,
Volume 1: Novel Drug Carriers and Volume 2: Drug Targeting Aspects
of Nanotechnology presents a comprehensive look at the
state-of-the-art research and developments in drug delivery systems
using nanotechnology and its applications. Many methods of drug
delivery systems have been used, but very few of them have been
validated for medical use. A major reason for the above situation,
the editors believe, is due to the gap between academia and
research, and the gap between academic research and real-time
clinical applications and needs. These volumes address that gap.
Volume 1 addresses the ubiquitous applications of nanotechnology or
nano-sized materials in the medical field and the real-world
challenges and complexities of current drug delivery methodologies
and techniques, while Volume 2 focuses on drug targeting aspects of
nanotechnology. Together they provide a thorough review of the
applications of nanotechnology or nano-sized materials in the
medical field and the real-world challenges and complexities of
current drug delivery methodologies and techniques. These two
volumes will provide a plethora of real-world information for the
application of drug delivery approaches via nanotechnology that
will be valuable to scientists and researchers as well as faculty
and students. The volumes are available separately or together as a
set.
Nutraceutical Fruits and Foods for Neurodegenerative Disorders
presents food-based strategies, specifically related to
nutraceuticals, in delaying the onset and slowing down of the
propensity of neuronal devastation. In addition to highlighting the
positive effects of nutraceutical fruits and foods on brain health,
the book also explores the medicinal properties of fruits,
vegetables, berries and nutraceuticals, along with their
contribution to environmental factors, potential hazards and the
need for specific regulatory actions. This book will be a welcomed
reference for nutrition researchers, dieticians, nutritionists and
academicians studying related fields.
Vitamins as Nutraceuticals The book examines the development of
nutraceutical products featuring maximizing the vitamin benefits to
human health and various health conditions. Since vitamins are
widely predicted to be one of the most significant nutritional
advancements over the next 25 years, the editors of this book have
brought together renowned experts in the field to provide a single
authoritative resource for the nutraceutical sector. It is being
published at a time when there is a pressing need to address the
rising number of cases of nutritional deficiency disorders and the
high number of deaths caused by a lack of knowledge or a deviation
from healthy eating habits. The book contains 12 chapters and
begins by defining and classifying the field of vitamins, with a
focus on legislative issues in both the United States and the
European Union. In addition to discussing recent advances and
applications, this book also includes scientific information on the
importance of vitamins as nutraceuticals to human health, as well
as the potential mechanisms of nutraceuticals in illness
prevention, management, and control. The focus is on vitamins as
nutraceuticals for health conditions such as human nutrition,
pregnancy, oral health, anemia, and blindness. The book also
explores the structure and function of various vitamins and covers
the impact of various vitamins on immunity and the nutraceutical
properties of seaweed vitamins and marine-derived sources of
nutritional vitamins. The beneficial effects of water-soluble
vitamins in nutrition, health promotion, and nutraceutical
potential of fat-soluble vitamins, are also discussed. Audience The
book will be read by a range of researchers and industry scientists
such as vitamin formulators, food scientists and food
manufacturers, as well as those in the pharmaceutical industry,
nanotech industry, novel drug delivery research laboratories, and
the health sector.
This volume addresses efforts to overcome the shortcomings of
conventional dosage forms by exploiting the principles of
nanoscience to deliver drugs for medical treatment. Nanodispersions
are an important aspect because they possess globules/particles in
sizes usually below 1000 nm in which the drug is dispersed in a
continuous medium employing surface-active agents as stabilizers.
With chapters written by experienced scientists and researchers in
the field, this volume provides an abundance of information on
various aspects of nanodispersions for drug delivery. The book is
divided into several sections: nanoemulsions, nanosuspensions, and
diverse dispersed systems. The chapters detail what nanodispersions
have demonstrated in the past and what they are expoected to
continue to do in the future as the technology further evolves. Key
features: * Provides an overview of nanoemulsions for drug delivery
* Introduces the general principles, classification, and methods of
preparation of nanoemulsion-based drug delivery systems * Presents
information relevant to specific routes of applications of
nanoemulsions * Looks at the various aspects of nanosuspensions,
including their formulation components, preparation methods, unique
features, methods of characterization, and applications in various
routes of administration * Explores nanomicellar approaches for
drug delivery * Discusses the preparation, applications, and
clinical considerations of nanogels for drug delivery
This book provides valuable coverage on various immunomodulatory
research associated with nutraceutical studies, from plant to
animal and marine sources. The book focuses on the various
properties of nutraceutical and functional foods, from dietary
fibers to fungus, marine sources, ginseng, and several others. Its
content is also dedicated to the nutraceutical potential and
applications of these modulators. The first section of this book
focuses mainly on the recent developments in nutraceutical and
functional food associated with various immunomodulators. The next
section covers the micronutrients and macronutrients level in order
to share important data and help readers gain a basic understanding
of the techno-functional, nutraceutical potential and applications
of nutritional treatment under specific disease conditions. A
detailed overview providing the structural and functional
properties related to immunomodulators will be highly beneficial
for academics and advanced-level students in immunology, food
science, clinical medicine, and life sciences.
This book focuses on a broad range of immunomodulators, including
both natural and synthetic ones. It highlights their role in human
health. The book discusses nanotechnology-based immunomodulators
with special emphasis on different types of formulation to boost
the immune system. It highlights the role of immunomodulators
against different microbes. This book describes important topics
such as Classification and uses of various immunomodulators;
Potential role of herbs and spices on immune system; Immune booster
activity of prebiotics; Recent advances of nutraceutical and
functional foods in Immune health; Antioxidants and
immunomodulation; Nanotechnology and immunomodulators in cancer;
Immunomodulatory role for the treatment and management of
tuberculosis; Immunomodulation in autoimmune disorders; Herbal
immunomodulators and COVID-19; Role of Cytokines as
Immunomodulators and Immunomodulatory effects of endocrine
disrupting chemicals. This book covers various aspects of product
innovation, development, and launching of nutritional and
pharmaceutical products with reference to immunomodulators. This
book is meant for researchers and students in the field of
immunology and pharmaceutical sciences.
This book focuses on a broad range of immunomodulators, including
both natural and synthetic ones. It highlights their role in human
health. The book discusses nanotechnology-based immunomodulators
with special emphasis on different types of formulation to boost
the immune system. It highlights the role of immunomodulators
against different microbes. This book describes important topics
such as Classification and uses of various immunomodulators;
Potential role of herbs and spices on immune system; Immune booster
activity of prebiotics; Recent advances of nutraceutical and
functional foods in Immune health; Antioxidants and
immunomodulation; Nanotechnology and immunomodulators in cancer;
Immunomodulatory role for the treatment and management of
tuberculosis; Immunomodulation in autoimmune disorders; Herbal
immunomodulators and COVID-19; Role of Cytokines as
Immunomodulators and Immunomodulatory effects of endocrine
disrupting chemicals. This book covers various aspects of product
innovation, development, and launching of nutritional and
pharmaceutical products with reference to immunomodulators. This
book is meant for researchers and students in the field of
immunology and pharmaceutical sciences.
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