This book comprises the proceedings of the 2nd International Conference on Computer Vision, High-Performance Computing, Smart Devices, and Networks (CHSN 2021). This book highlights the high-quality research articles in machine learning, computer vision, and networks. The content of this volume gives the reader an up-to-date picture of the state-of-the-art connection between computational intelligence, machine learning, and IoT. The papers included in this volume are peer-reviewed by experts in the related areas. The book will serve as a valuable reference resource for academics and researchers across the globe.