The Future of Pharmaceutical Product Development and Research examines the latest developments in the pharmaceutical sciences, also highlighting key developments, research and future opportunities. Written by experts in the field, this volume in the Advances in Pharmaceutical Product Development and Research series deepens our understanding of the product development phase of drug discovery and drug development. Each chapter covers fundamental principles, advanced methodologies and technologies employed by pharmaceutical scientists, researchers and the pharmaceutical industry. The book focuses on excipients, radiopharmaceuticals, and how manufacturing should be conducted in an environment that follows Good Manufacturing Practice (GMP) guidelines. Researchers and students will find this book to be a comprehensive resource for those working in, and studying, pharmaceuticals, cosmetics, biotechnology, foods and related industries.

This issue of PET Clinics focuses on Special Techniques and Technical Advances in PET/CT Imaging. Articles will include: PET/CT Guided FNAC/Biopsy; Dual Time Point Imaging; Overview of Conventional imaging based intervention in clinical practice; Special Techniques in PET/CT in evaluating genito-urinary malignances; Special techniques in PET/CT imaging for evaluation of head and neck cancer; PET/CT enteroclysis; Contrast media in PET/CT imaging; PET/CT guided RFA; Non-attenuated corrected PET/CT imaging and applications; and more!

In todays’ world with its widespread usage of personal-care products, pharmaceuticals, surfactants, flame retardants, plasticizers, various industrial additives, metals and metalloids, pesticides, and pesticide metabolites, environmental contaminants are an increasing source of pollution with a severe effect on the ecological system. Industries that produce these contaminants must find answers to remediate this. Nanomaterials in Environmental Analysis contributes to solving this problem by providing researchers in industry and academia with promising applications of nanoparticles in detection techniques and in removal of chemical species from the environment. Each chapter covers an aspect of using nanoparticles in detecting, measuring and remediating toxic chemical species in the environment.

Strategic Perspectives in Solid Waste and Wastewater Management explores conventional and advanced biotechnologies for waste management, including socio-economic aspects, techno-economic feasibility, models and modeling tools, and a detailed life-cycle assessment approach in solid waste (SW) and wastewater (WW). These innovative technologies are highly applicable to current real-world situations. The enormous increase in the quantum and diversity of SW and WW - including waste materials generated due to human activity and their potentially harmful effects on the environment and public health - have led to increasing awareness about an urgent need to adopt novel technologies for appropriate management of both SW and WW. While there is an obvious need to minimize the generation of wastes and to reuse and recycle them, the technologies for managing such wastes can play a vital role in mitigating problems. Besides recovery of substantial energy, these technologies can lead to a considerable reduction in the overall waste quantities requiring final disposal, which can be better managed for safe disposal in a controlled manner while meeting pollution control standards.

Microelectromechanical systems (MEMS) device applications are common in many areas. Micromirror arrays are used as video projectors; microsensors find their application for measuring acceleration, temperature, and pressure; and they can also be used in the medical field for measuring blood pressure. Microfluidics have also been widely employed in life sciences applications, such as drug development and administration, point-of-care devices, and more. To use these technologies to their fullest extent, further research is needed. Advances in MEMS and Microfluidic Systems explores the emerging research and advances in MEMS devices and microfluidic systems applications. It features in-depth chapters on microfluidic device design and fabrication as well as on the aspects of devices/systems, characterization, and comparative research findings. Covering topics such as biosensors, lab-on-a-chip, and microfluidic technology, this premier reference source is an indispensable resource for engineers, health professionals, students and educators of higher education, librarians, researchers, and academicians.

This book gives a complete overview of current developments in nanotechnology-based environmental remediation and sustainable agriculture practices/sectors. It will provide the use of nanotechnology in the agricultural sector such as crop production and improvement, soil fertility management along with benefits and risks of nanotechnology on ecological farming. Additionally, the book also discovers how nanotechnology is used in water, air remediation techniques and major challenges in using nanomaterials for improving water and air quality. The book can be a reference source for academicians, scientists, policymakers, students, and research scientists working in minimizing the environmental pollution and increasing agricultural production using nanoparticles.

Toxicity and Toxicodynamics in Drug Research, Volume 1: Essentials in Pharmatoxicology provides an overview on the essentials of toxicology, risk assessment, and the mechanisms that might occur as the result of toxicological and the potentially harmful action and response of pharmaceuticals. Volume 1: Essentials in Pharmatoxicology opens with an introduction to pharmatoxicology and toxicology in drug research. It covers topics such as the types of cellular responses to chemical toxicants, the mechanisms of drug toxicity, and their relevance to pharmaceutical product development. The book examines omics and computer-aided technologies for mechanistic and predictive toxicology. The book also covers state-of-art testing in the evaluation of detrimental pathways, dose selection in toxicity studies, as well as expounds on the role of regulatory agencies in toxicity studies. It covers the mechanistic pathways of food toxicants and illustrates the molecular mechanisms of the chemopreventive role of dietary phytochemicals. There is also discussion on clinical interventions such as pharmacotherapy and managed care strategies for acute poisoning. This volume is a valuable resource to those learning more about the drug development process related to toxicology and those who want to get an update on newer concepts on the toxicology aspect of drug research.

Increased use of artificial intelligence (AI) is being deployed in many hospitals and healthcare settings to help improve health care service delivery. Machine learning (ML) and deep learning (DL) tools can help guide physicians with tasks such as diagnosis and detection of diseases and assisting with medical decision making. This edited book outlines novel applications of AI in e-healthcare. It includes various real-time/offline applications and case studies in the field of e-Healthcare, such as image recognition tools for assisting with tuberculosis diagnosis from x-ray data, ML tools for cancer disease prediction, and visualisation techniques for predicting the outbreak and spread of Covid-19. Heterogenous recurrent convolution neural networks for risk prediction in electronic healthcare record datasets are also reviewed. Suitable for an audience of computer scientists and healthcare engineers, the main objective of this book is to demonstrate effective use of AI in healthcare by describing and promoting innovative case studies and finding the scope for improvement across healthcare services.

Pharmacokinetics and Toxicokinetic Considerations explains the central principles, cutting-edge methodologies, and incipient thought processes applied to toxicology research. As part of the Advances in Pharmaceutical Product Development and Research series, the book provides expert literature on dose, dosage regimen and dose adjustment, medication errors, and approaches for its prevention, the concept of pharmacotherapy, and managed care in clinical interventions. It expounds on strategies to revamp the pharmacokinetics of the drug and the factors affecting the stability of drugs and their metabolites in biological matrices. Finally, the book offers focused elaborations on various bioanalytical methods for bioavailability and bioequivalence assessment and integrates the wide-ranging principles and concepts shared by toxicokinetics and pharmacodynamics as mutual crosstalk rather than isolated observations. It will be helpful to researchers and advanced students working in the pharmaceutical, cosmetics, biotechnology, food, and related industries including toxicologists, pharmacists, and pharmacologists.

Biopharmaceutics and Pharmacokinetics Considerations examines the history of biopharmaceutics and pharmacokinetics. The book provides a biopharmaceutics and pharmacokinetics approach to addressing issues in formulation development and ethical considerations in handling animals. Written by experts in the field, this volume within the Advances in Pharmaceutical Product Development and Research series deepens understanding of biopharmaceutics and pharmacokinetics within drug discovery and drug development. Each chapter delves into a particular aspect of this fundamental field to cover the principles, methodologies and technologies employed by pharmaceutical scientists, researchers and pharmaceutical industries to study the chemical and physical properties of drugs and the biological effects they produce.

This edited book is a compilation of tangible research findings and actual experiences on various salt tolerant rice breeding programmes, that have been successfully practiced and continuing to do so by research centres in South East Asia, with major emphasis in India, Bangladesh and Philippines. Rice being one of the most important staple crops of the world, its production and productivity have to be kept on increasing so as to feed the burgeoning population. This is a very challenging task in the midst of shrinking resource base and arable lands in the face of climate change. Salt stress is the second major abiotic stress, next only to drought, which greatly affects rice production. To overcome this problem, development of improved salt tolerant rice cultivars coupled with appropriate package of practices, an ecologically sound and socially acceptable strategy should be developed which is well within the reach of marginal farmers. With rapid advances in molecular biology, mechanisms underlying the complexity of the trait are better understood now than before. Selection of appropriate parents, desired mapping populations, precise phenotyping are the key components to underpin the mapping and utilization of reliable QTLs. Understanding genetics of salt tolerance, identifying the robust molecular markers and targeted utilization of available molecular markers form the sound basis to develop the commercial products with more precision and speed. This book covers entire range of topics: starting from biophysical characterization of salt stressed areas in different rice ecologies, conventional and molecular breeding approaches for mapping salt tolerance and subsequent development of improved rice varieties for commercial cultivation and their societal impacts. This book is of interest to scientists, faculty, policy makers and administrators. It also serves as a resource guide to graduate students of agriculture particularly plant breeding, plant physiology, molecular biology and soil science.

This issue, edited by Dr. Rakesh Kumar, reviews current clinical information in "PET Based Interventions." Articles will include: PET/CT in Radiofrequency Ablation; PET/CT Guided FNAC/Biopsy; PET/CT in Radiotherapy Planning; Dual Time Point Imaging; The Role of PET in Radiation Oncology; PET/CT in Individualization of Treatment (Personalized medicine); Ga68-DOTA-TOC PET/CT in targeted radionuclide therapy (Lu188 therapy for NET); Role of FDG PET/CT in Targeted Radionuclide Therapy of Endocrine Malignancies; Overview of Conventional Imaging Based Intervention in Clinical Practice; Special Techniques in PET/CT in Evaluating Genito-urinary Malignancies; and more!

This two part issue of PET Clinics provides a comprehensive review to the important topic of Breast Cancer. Although the focus of this issue is the use of PET and PET/CT in the diagnosis, staging, treatment planning, and follow up for patients with breast cancer, there are also articles providing correlates from other imaging modalities.

This two part issue of PET Clinics provides a comprehensive review to the important topic of Breast Cancer. Although the focus of this issue is the use of PET and PET/CT in the diagnosis, staging, treatment planning, and follow up for patients with breast cancer, there are also articles providing correlates from other imaging modalities.

Smart cities of the future must aspire to accommodate increasing technology and expectations of modern living, integrated societies, knowledge-based workforce, factory automation, and virtual-real social behaviors. This complex concoction of challenges requires new thinking of the synergistic utilization of reinforcement learning methods and data-driven decision making with automation infrastructure, autonomous transportation, connected buildings, smart homes, and embedded communities. Industrial informatics lies at this strategic intersection of multiple disciplines that can comprehensively realize a learning vision of smart cities. This book is ideal for academicians, researchers, authors, industry experts, software engineers, and students.

At the moment, there is no dedicated book to summarize the roles, the significance, and potential therapeutic targeting of transcriptional factors from the perspective of signaling cascade, and thus, directly impacting the functionality of transcriptional factors in cancer. In addition, this book will offer a comprehensive basic and clinical science behind the functions of representative core transcriptional factors. These chapters will serve as a treasure for all those who have an interest in the basis, progression, and targeting of human cancer. Each chapter will be intended to provide comprehensive, up-to-date information by the leaders about the physiologic and pathologic roles of TFs in specific representative organ systems of prime importance. The book will consist of chapters that will give biomedical students, under and graduate students, basic sciences and clinical cancer fellows, residents and researchers, and oncology educators will get a thorough summary of the overall subject. The readers will be able to understand the important current information and views on specific TFs and its role in cancer in areas outside their own expertise or experience. A special emphasis will be also placed on the "classic" papers as well as perspectives on future directions for the field.

Traditionally, scientific fields have defined boundaries, and scientists work on research problems within those boundaries. However, from time to time those boundaries get shifted or blurred to evolve new fields. For instance, the original goal of computer vision was to understand a single image of a scene, by identifying objects, their structure, and spatial arrangements. This has been referred to as image understanding. Recently, computer vision has gradually been making the transition away from understanding single images to analyz ing image sequences, or video understanding. Video understanding deals with understanding of video sequences, e. g., recognition of gestures, activities, fa cial expressions, etc. The main shift in the classic paradigm has been from the recognition of static objects in the scene to motion-based recognition of actions and events. Video understanding has overlapping research problems with other fields, therefore blurring the fixed boundaries. Computer graphics, image processing, and video databases have obvious overlap with computer vision. The main goal of computer graphics is to gener ate and animate realistic looking images, and videos. Researchers in computer graphics are increasingly employing techniques from computer vision to gener ate the synthetic imagery. A good example of this is image-based rendering and modeling techniques, in which geometry, appearance, and lighting is de rived from real images using computer vision techniques. Here the shift is from synthesis to analysis followed by synthesis."

This book describes intuitive analog design approaches using digital inverters, providing filter architectures and circuit techniques enabling high performance analog circuit design. The authors provide process, supply voltage and temperature (PVT) variation-tolerant design techniques for inverter based circuits. They also discuss various analog design techniques for lower technology nodes and lower power supply, which can be used for designing high performance systems-on-chip.

Water transmission and distribution systems are pressurized hydraulic networks, consisting of pipes and other appurtenant components such as reservoirs, pumps, valves and surge devices. Analysis, design and flow control problems in such systems can best be dealt with using network synthesis. This approach aims to directly determine design variables in order to achieve a specified behaviour of the system under steady state or transient flow conditions. There are enormous advantages to be achieved in applying such a model to a wide variety of problems in engineering practice. The innovative theoretical framework described in this thesis, incorporates necessary and sufficient conditions for solvability, as well as methods/algorithms for the efficient solution of network problems.

Our limited understanding of cellular regulatory signal-transduction-networks has been a barrier to progress in improving the overall cure-rate of human cancers. Delineation of the physiologic roles of the specific regulatory signaling components, with known association with metastatic phenotypes, is a highly promising area which will likely provide the next generation of targeted strategies in the future of molecular cancer medicine. These signaling components are likely to be used in diagnosis, prognosis, and as novel targets for therapeutic development.

This book brings together up-to-date summaries by leading cancer researchers on the major principles of cancer cell biology: survival, apoptosis, adhesion, and cell cycle deregulation. It is directed at clinicians and scientists working in the areas of experimental and molecular therapeutics, molecular medicine, translational cancer research, and bio-medical sciences in general.