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This updated and expanded volume reflects the current state of the
structural protein field with improved and refined protocols that
have been applied to particularly challenging proteins. Beginning
with a section on structural bioinformatics, the book continues
with sections covering the challenge of producing high quality
samples for structural studies, particularly mammalian membrane
proteins and protein complexes, as well as protocols for structure
determination, including the use of electrons in structural biology
and more. Written for the highly successful Methods in Molecular
Biology series, chapters include introductions to their respective
topics, lists of the necessary materials and reagents,
step-by-step, readily reproducible laboratory protocols, and tips
on troubleshooting and avoiding known pitfalls. Authoritative and
up-to-date, Structural Proteomics: High-Throughput Methods, Third
Edition will aid researchers in expanding our knowledge of this
vital and expansive area of protein science. Chapter 9 is available
open access under a CC BY 4.0 license.
This updated and expanded volume reflects the current state of the
structural protein field with improved and refined protocols that
have been applied to particularly challenging proteins, notably
integral membrane proteins and multi-protein complexes. Structural
Proteomics: High-Throughput Methods, Second Edition begins by
exploring the resources available for curation, annotation, and
structure prediction in silico, and continues with methods for
sample preparation of both proteins and crystals, as well as
structural characterization techniques. Written for the highly
successful Methods in Molecular Biology series, chapters include
introductions to their respective topics, lists of the necessary
materials and reagents, step-by-step, readily reproducible
laboratory protocols, and tips on troubleshooting and avoiding
known pitfalls. Practical and up-to-date, Structural Proteomics:
High-Throughput Methods, Second Edition will aid researchers in
expanding our knowledge of this vital and expansive area of protein
science.
It has been predicted that nearly half of all human proteins are
glycosylated indicating the significance of glycoproteins in human
health and disease. For example, the glycans attached to proteins
have emerged as important biomarkers in the diagnosis of diseases
such as cancers and play a significant role in how pathogenic
viruses gain entry into human cells. The study of glycoproteins has
now become a truly proteomic science. In the last few years,
technology developments including in silico methods, high
throughput separation and detection techniques have accelerated the
characterization of glycoproteins in cells and tissues.
Glyco-engineering coupled to rapid recombinant protein production
has facilitated the determination of glycoprotein structures key to
exploring and exploiting their functional roles. Each chapter in
this volume is written by experts in the field and together provide
a review of the state of the art in the emerging field of
glycoproteomics.
It has been predicted that nearly half of all human proteins are
glycosylated indicating the significance of glycoproteins in human
health and disease. For example, the glycans attached to proteins
have emerged as important biomarkers in the diagnosis of diseases
such as cancers and play a significant role in how pathogenic
viruses gain entry into human cells. The study of glycoproteins has
now become a truly proteomic science. In the last few years,
technology developments including in silico methods, high
throughput separation and detection techniques have accelerated the
characterization of glycoproteins in cells and tissues.
Glyco-engineering coupled to rapid recombinant protein production
has facilitated the determination of glycoprotein structures key to
exploring and exploiting their functional roles. Each chapter in
this volume is written by experts in the field and together provide
a review of the state of the art in the emerging field of
glycoproteomics.
This updated and expanded volume reflects the current state of the
structural protein field with improved and refined protocols that
have been applied to particularly challenging proteins. Beginning
with a section on structural bioinformatics, the book continues
with sections covering the challenge of producing high quality
samples for structural studies, particularly mammalian membrane
proteins and protein complexes, as well as protocols for structure
determination, including the use of electrons in structural biology
and more. Written for the highly successful Methods in Molecular
Biology series, chapters include introductions to their respective
topics, lists of the necessary materials and reagents,
step-by-step, readily reproducible laboratory protocols, and tips
on troubleshooting and avoiding known pitfalls. Authoritative and
up-to-date, Structural Proteomics: High-Throughput Methods, Third
Edition will aid researchers in expanding our knowledge of this
vital and expansive area of protein science. Chapter 9 is available
open access under a CC BY 4.0 license.
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