It has been predicted that nearly half of all human proteins are
glycosylated indicating the significance of glycoproteins in human
health and disease. For example, the glycans attached to proteins
have emerged as important biomarkers in the diagnosis of diseases
such as cancers and play a significant role in how pathogenic
viruses gain entry into human cells. The study of glycoproteins has
now become a truly proteomic science. In the last few years,
technology developments including in silico methods, high
throughput separation and detection techniques have accelerated the
characterization of glycoproteins in cells and tissues.
Glyco-engineering coupled to rapid recombinant protein production
has facilitated the determination of glycoprotein structures key to
exploring and exploiting their functional roles. Each chapter in
this volume is written by experts in the field and together provide
a review of the state of the art in the emerging field of
glycoproteomics.
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