This book constitutes the refereed proceedings of the 12th International Conference on Intelligent Technologies for Interactive Entertainment, INTETAIN 2020. Due to COVID-19 pandemic the conference was held virtually.The 19 full papers were selected from 49 submissions and present novel, and innovative work in areas including in art, science, design and engineering regarding computer-based systems or devices that provide intelligent human interaction or entertainment experience. The papers are grouped in sessions on thematical issues on Big Ideas and Ethics; Haptics, Audio, and Internet of Things (IoT); Industry and Government; Machine Learning (ML); and Extended Reality (XR) and Human Computer Interaction (HCI).