This book provides a broad overview of diagnostic pathology, integrating historical perspectives with the current practice of diagnostic pathology across various sub-fields such as surgical pathology,  cytopathology, autopsy and forensic pathology, neuropathology and more.   Pathology: Historical and Contemporary Aspects presents contemporary issues that are crucial to the practice of pathology in the 21st century, including the development and application of key techniques and technical aspects such as immunohistochemistry and molecular diagnostics, as well as computer applications such as image analysis and artificial intelligence. The history of the field in the West is covered in detail, including the history and current standing of major pathology societies, in addition to a concise overview of the development of pathology in Eastern countries such as China and Japan. It details the work of some outstanding individuals who have contributed to advances in pathology, from Nobel laureates to traditionally under-represented groups such as women and minorities. 

"Endocrine Pathology" integrates classical diagnostic anatomic pathology with recent developments in immunochemistry and molecular biology in its approach to endocrine disorders. The book discusses not only a wide range of diseases commonly encountered in everyday clinical practice but also those uncommon conditions elucidated by such innovative techniques as ultrastructural immunochemistry and in situ hybridization.

A comprehensive review of recent molecular discoveries that can clarify the pathophysiology of endocrine disease processes and contribute to the diagnostic aspects of endocrine pathology. Surgeons, medical oncologists, and radiation therapists discuss the treatment of endocrine disorders, especially tumors, with emphasis on differential diagnosis and on broadening the perspective that the endocrine pathologist must have in making specific tissue diagnoses. Of interest to practicing pathologists, pathology residents, endocrinologists, endocrinologists in training, veterinarians, and interested researchers.

Endocrine Pathology: Differential Diagnosis and Molecular Advances, Second Edition provides detailed coverage of endocrine pathology with extensive discussion of the differential diagnosis as well as presentation of molecular pathobiology of the major endocrine organs. Revised and expanded from the first edition, each chapter, written by leaders in their respective field, has been updated with the latest advances that are transforming the field of endocrine pathology. Richly illustrated with color photomicrographs, useful diagrams and line drawings, each chapter includes differential diagnosis of common and uncommon lesions as well as material on molecular developments, with emphasis on the molecular findings that are most helpful in the diagnosis of specific disorders. Endocrine Pathology: Differential Diagnosis and Molecular Advances, Second Edition, provides a useful and well-organized resource designed not only for the endocrine pathologist and the general surgical pathologist, but also for the clinical endocrinologist and the endocrine surgeon.

Eminent clinicians and specialists thoroughly review in great detail every aspect of pituitary tumors. The topics covered include prolactinomas, somatotroph adenomas, corticotroph adenomas, thyrotroph adenomas, nonfunctioning tumors, pituitary tumors, invasive adenomas, and pituitary carcinomas, as well as lesions, exclusive of pituitary adenomas, that occur in the sellar region. Also discussed are the new methods in endocrine diagnosis, high resolution imaging, receptor-mediated pharmacotherapy, microsurgical techniques, improved methods of radiation delivery, and the development of a precise and physiologically meaningful classification of pituitary tumors. Much-needed and brilliantly multidisciplinary, Diagnosis and Management of Pituitary Tumors offers all those dealing with pituitary cancer patients today's most comprehensive guide to diagnosis and treatment, one whose coordinated treatment strategies have sharply improved long-term survival rates for many patients.

The past several decades have witnessed an impressive array of conceptual and techno logical advances in the biomedical sciences. Much of the progress in this area has developed directly as a result of new morphology-based methods that have permitted the assessment of chemical, enzymatic, immunological, and molecular parameters at the cellular and tissue levels. Additional novel approaches including laser capture microdissection have also emerged for the acquisition of homogeneous cell popula tions for molecular analyses. These methodologies have literally reshaped the approaches to fundamental biological questions and have also had a major impact in the area of diagnostic pathology. Much of the groundwork for the development of morphological methods was estab th lished in the early part of the 19 century by Francois-Vincent Raspail, generally acknowledged as the founder of the science of histochemistry. The earliest work in the field was primarily in the hands of botanists and many of the approaches to the under standing of the chemical composition of cells and tissues involved techniques such as microincineration, which destroyed structural integrity. The development of aniline th dyes in the early 20 century served as a major impetus to studies of the structural rather than chemical composition of tissue. Later in the century, however, the focus returned to the identification of chemical constituents in the context of intact cell and tissue structure.

The past several decades have witnessed an impressive array of conceptual and techno logical advances in the biomedical sciences. Much of the progress in this area has developed directly as a result of new morphology-based methods that have permitted the assessment of chemical, enzymatic, immunological, and molecular parameters at the cellular and tissue levels. Additional novel approaches including laser capture microdissection have also emerged for the acquisition of homogeneous cell popula tions for molecular analyses. These methodologies have literally reshaped the approaches to fundamental biological questions and have also had a major impact in the area of diagnostic pathology. Much of the groundwork for the development of morphological methods was estab th lished in the early part of the 19 century by Francois-Vincent Raspail, generally acknowledged as the founder of the science of histochemistry. The earliest work in the field was primarily in the hands of botanists and many of the approaches to the under standing of the chemical composition of cells and tissues involved techniques such as microincineration, which destroyed structural integrity. The development of aniline th dyes in the early 20 century served as a major impetus to studies of the structural rather than chemical composition of tissue. Later in the century, however, the focus returned to the identification of chemical constituents in the context of intact cell and tissue structure."

The purpose of this atlas is to provide surgical pathologists with ready expert reference material most helpful in their daily practice. The lesions described relate principally to medical non-neoplastic conditions as exemplified by our first three Fascicles on endocrine, pulmonary, and skin diseases. Many of these lesions represent complex entities and when appropriate, we have included contributions from internists, radiologists, and surgeons. This has led to some increase in the size of the monographs but the emphasis remains on diagnosis by the surgical pathologist.