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5 matches in All Departments
This title reviews current knowledge of the mechanisms contributing
to heart failure. Editor Richard Walsh and an internationally
renowned team of contributors discuss key advances in molecular and
cell biology, biochemistry, and pharmacology, focusing on advances
that have a direct bearing on current clinical studies. It
highlights developments across a broad range of disciplines, with
in-depth coverage of each topic providing background and
perspective on current literature. By setting new advances in a
broader context, this text allows readers to compare different
ideas and evaluate their importance in their own areas of research
or clinical practice.
Unique in its focus on this particular field of cardiovascular
science, Molecular Mechanisms of Cardiac Hypertrophy and Failure
reviews current knowledge of the mechanisms contributing to heart
failure.Bringing together an internationally renowned team of
contributors, the text provides expert reviews on the latest
advances in molecular and cell biology, biochemistry and
pharmacology. scientists in academia and industry, the book has
particular emphasis on the following key areas: - cardiac
hypertrophy - contractile depression - arrhythmogenesis - genetics
- the clinical implications of the research in these areas.
interest to clinical cardiologists, vascular medicine specialists,
hematologists, and internists, as well as members of the
cardiovascular research community and pharmaceutical and
biotechnology industries.
The enormous advances in molecular biology and genetics coupled
with the progress in instrumentation and surgical techniques have
produced a voluminous and often bewildering quantity of data. The
primary objective of a second edition of Cardiovascular Physiology
in the Genetically Engineered Mouse is to interpret critically the
literature and to provide a framework for the enormous amount of
information in this burgeoning field. As in the first edition, the
monograph serves as a practical guide for the investigator
interested in the functional methods used to characterize the
murine cardiovascular phenotype. The monograph is organized into
three parts. The first deals with principles of transgenesis and
homologous recombination. The second part, which again is the
largest, discusses the various techniques used to assess the
cardiovascular mechanical, metabolic, and electrophysiologic
phenotype. This section is organized in a hierarchical manner- i.e.
from isolated myocyte to isolated heart to the intact, anesthetized
and conscious mouse.The third part examines techniques used to
evaluate murine smooth muscle function, genetic mouse models of
hypertrophy and heart failure, and the methods to assess the
cardiovascular phenotype in the developing mouse embryo. In
addition, newer methods that 'push the envelope', such as magnetic
resonance imaging (MRI), positron emission tomography (PET),
ultrasound biomicroscopy (UBM), and computed tomography (microCT)
are discussed. Expanded and updated, each chapter is richly
enhanced with original tables and figures, and in many cases,
extensively rewritten when compared with the first edition. An
essential and enduring goal of this second edition is to continue
to facilitate interactions between the basic science disciplines
and help bridge the gap between molecular biology and physiology.
The enormous advances in molecular biology and genetics coupled
with the progress in instrumentation and surgical techniques have
produced a voluminous and often bewildering quantity of data. The
primary objective of a second edition of Cardiovascular Physiology
in the Genetically Engineered Mouse is to interpret critically the
literature and to provide a framework for the enormous amount of
information in this burgeoning field. As in the first edition, the
monograph serves as a practical guide for the investigator
interested in the functional methods used to characterize the
murine cardiovascular phenotype. The monograph is organized into
three parts. The first deals with principles of transgenesis and
homologous recombination. The second part, which again is the
largest, discusses the various techniques used to assess the
cardiovascular mechanical, metabolic, and electrophysiologic
phenotype. This section is organized in a hierarchical manner- i.e.
from isolated myocyte to isolated heart to the intact, anesthetized
and conscious mouse. The third part examines techniques used to
evaluate murine smooth muscle function, genetic mouse models of
hypertrophy and heart failure, and the methods to assess the
cardiovascular phenotype in the developing mouse embryo. In
addition, newer methods that push the envelope', such as magnetic
resonance imaging (MRI), positron emission tomography (PET),
ultrasound biomicroscopy (UBM), and computed tomography (microCT)
are discussed. Expanded and updated, each chapter is richly
enhanced with original tables and figures, and in many cases,
extensively rewritten when compared with the first edition. An
essential and enduring goal of this second edition isto continue to
facilitate interactions between the basic science disciplines and
help bridge the gap between molecular biology and physiology.
Part of the "What Do I Do Now?" series, Movement Disorders uses a
case-based approach to cover common and important topics in the
examination, investigation, and management of Parkinson's disease,
gait disorders, dystonia, and other movement disorders. Each
chapter provides a discussion of the diagnosis, key points to
remember, and selected references for further reading. For this
edition, all cases and references have been updated and fifteen new
cases have been added including: Genetic testing in Parkinson's
disease, Dementia with Lewy Bodies, Fragile X Tremor Ataxia
Syndrome, Botulinum Toxin, Catatonia, and Serotonin Syndrome.
Movement Disorders is an engaging collection of thought-provoking
cases which clinicians can utilize when they encounter difficult
patients. The volume is also a self-assessment tool that tests the
reader's ability to answer the question, "What do I do now?"
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