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Books > Medicine > Clinical & internal medicine > Cardiovascular medicine
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Cardiovascular Physiology in the Genetically Engineered Mouse (Paperback, 2nd ed. 2002)
Loot Price: R4,385
Discovery Miles 43 850
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Cardiovascular Physiology in the Genetically Engineered Mouse (Paperback, 2nd ed. 2002)
Series: Developments in Cardiovascular Medicine, 238
Expected to ship within 10 - 15 working days
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The enormous advances in molecular biology and genetics coupled
with the progress in instrumentation and surgical techniques have
produced a voluminous and often bewildering quantity of data. The
primary objective of a second edition of Cardiovascular Physiology
in the Genetically Engineered Mouse is to interpret critically the
literature and to provide a framework for the enormous amount of
information in this burgeoning field. As in the first edition, the
monograph serves as a practical guide for the investigator
interested in the functional methods used to characterize the
murine cardiovascular phenotype. The monograph is organized into
three parts. The first deals with principles of transgenesis and
homologous recombination. The second part, which again is the
largest, discusses the various techniques used to assess the
cardiovascular mechanical, metabolic, and electrophysiologic
phenotype. This section is organized in a hierarchical manner- i.e.
from isolated myocyte to isolated heart to the intact, anesthetized
and conscious mouse.The third part examines techniques used to
evaluate murine smooth muscle function, genetic mouse models of
hypertrophy and heart failure, and the methods to assess the
cardiovascular phenotype in the developing mouse embryo. In
addition, newer methods that 'push the envelope', such as magnetic
resonance imaging (MRI), positron emission tomography (PET),
ultrasound biomicroscopy (UBM), and computed tomography (microCT)
are discussed. Expanded and updated, each chapter is richly
enhanced with original tables and figures, and in many cases,
extensively rewritten when compared with the first edition. An
essential and enduring goal of this second edition is to continue
to facilitate interactions between the basic science disciplines
and help bridge the gap between molecular biology and physiology.
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