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A concise guide to cycling LEJOG - Land's End to John o' Groats -
describing an idyllic route that follows quieter roads and
traffic-free paths but without too much meandering. Covering 1000
miles, the route is divided into 14 stages and can be comfortably
ridden in two weeks. Easy-to-follow route descriptions are
accompanied by clear mapping and useful gradient profiles, together
with route highlights and points of interest, of which there are
many. Invaluable tips and tricks are also included from preparing
yourself to preparing your bike, together with logistical advice
such as getting to and from the start and finish, accommodation
options and more. In addition to the main 14-stage schedule (which
includes an alternative option through Central Scotland), longer
and shorter schedules are also suggested, making it easy to prepare
a personally tailored adventure. The route, which passes through a
diverse range of landscapes, from almost sea level across the
Somerset Levels to over 1400ft through the magnificent Cairngorm
Mountains, showcases some of Britain's best cycling. It is a must
for anyone who's ever been remotely tempted to take on this iconic
end-to-end challenge.
This guidebook describes 30 day walks all over the Isles of Harris
and Lewis, in the Outer Hebrides. The walks range from 2 and 14
miles (4 to 22km) in length, and are easily accessible from
Stornaway or Tarbet. Routes vary from short strolls to long
wilderness hikes, high-level and low-level, and include the An
Cliseam horseshoe, visits to ancient historic monuments like the
stone circles of Calanais and the famous Butt of Lewis lighthouse,
all illustrated with OS 1:50,000 maps and dramatic photography. The
routes take in most of the main summits as well as historical and
geographical places of interest. A list of all the Marilyns
(British hills of any height with a drop of at least 150m on all
sides) on Harris, Lewis and St Kilda is included at the back. Tips
are also included about walking on St Kilda, Berneray, Taransay,
The Shiant Islands and The Flannan Isles, along with a short Gaelic
glossary and route summary table, and advice on practicalities to
make the most out of any walking trip on Harris and Lewis.
Guidebook to cycling Lon Las Cymru, a 255 mile (410km) route from
Cardiff, or 242 mile (390km) from Chepstow to Holyhead, showcasing
Wales's beautiful rural heartland. Divided into 5 stages, the route
(which follows quiet roads and traffic-free paths) is described
south to north from both Cardiff and Chepstow. Accompanying route
description for each stage is 1:100,000 mapping and elevation
profiles, giving a clear indication of course. Suggested summary
schedules from both start destinations are included, detailing
possible 4 to 7 day cycle options. Also included is handy practical
information about transport to and from the route, accommodation en
route, baggage transfer options and preparing your bike. Passing
through the Brecon Beacons National Park, Snowdonia National Park,
and over the Black Mountains, the Brecon Beacons and the Cambrian
Mountains, the route is as scenic as it is rewarding making it a
ride to remember.
Guidebook to cycle touring in Wales. Catering to just about any
itinerary, it describes a 657 mile circuit of Wales - perfect for a
two-week adventure - plus 6 cross routes, which range from 45 to 73
miles and can be completed as day/weekend rides, or used to create
shorter versions of the main circuit. This guide includes all the
information needed to plan and execute a successful tour. In
addition to clear route description, 1:200K mapping and gradient
profiles, there is advice on selecting a schedule, planning your
trip, preparing your bike and organising logistics, such as
accommodation, getting to and from the start, and ways to carry (or
not carry) your kit. Also includes a handy cycle shop listing, a
Welsh glossary and checklist of things to take. Showcasing mile
after mile of stunning coastal scenery, quaint seaside towns,
rolling marcher country, as well as an impressive collection of
castles, industrial archaeology, churches, chapels and prehistoric
sites, Wales is a veritable delight for the cycling enthusiast.
Discover verdant green valleys, skirt wild mountains, soak up
Pembrokeshire's salty sea air and boast of your pedal up the
highest road in Wales.
Officially launched in 2017, the Hebridean Way offers walkers the
opportunity to experience the magic of Scotland's Outer Hebrides in
one inspirational journey. The waymarked route stretches 247km (155
miles) from Vatersay to Stornaway, linking ten major islands of the
archipelago by means of causeways and two ferry crossings:
Vatersay, Barra, Eriskay, South Uist, Benbecula, Grimsay, North
Uist, Berneray, Harris and Lewis. Suitable for most walkers with a
moderate level of fitness, it can be completed in 8-14 days and is
rich in natural, historical and cultural interest. This guidebook
presents the Hebridean Way in 10 stages of 16-35km (10-22 miles),
plus two additional stages to extend the route to the Butt of Lewis
in line with future plans. Detailed route description is
accompanied by 1:50,000 OS mapping, stunning photography to whet
your appetite and a wealth of information about local points of
interest. The introduction offers an overview of the islands'
geology, history, plants and wildlife as well as comprehensive
practical advice for walking the route, such as when to go, how to
get there (and back) and what to take. Accommodation listings can
be found in the appendices. The route is a celebration of the
diverse landscapes of the Hebrides, from dazzling white shell
beaches to wild moorland and flower-strewn machair. It visits
Neolithic and Bronze Age remains, ruined forts and castles and
monuments commemorating Bonnie Prince Charlie and the Highland Land
Struggle. The islands are also a great location to spot seabirds,
raptors and a number of migratory species.
Values-driven organizations are the most successful organizations
on the planet. This book explains that understanding employees'
needs-what people value-is the key to creating a high performing
organization. When you support employees in satisfying their needs,
they respond with high levels of engagement and willingly commit
their energies to the organization, bringing passion and creativity
to their work. This new edition of The Values-Driven Organization
provides an updated set of tools to assess corporate culture, new
case studies on cultural transformation and additional materials on
sustainability, measuring cultural health at work and the specific
needs of the millennial generation. The Values-Driven Organization
is essential reading for students, researchers and practitioners of
organizational change, leadership, HRM and business ethics.
This guidebook describes 37 day rides for all abilities, and 22
linking routes for more experienced cycle tourists, allow riders to
visit all the essential sights in over 20 islands of the Hebrides
and of the Firth of Clyde. Routes range from those suitable for
short weekend breaks to a challenging 600-mile tour (includes the
200 mile Hebridean Way / NCR 780 along the length of the Outer
Hebrides). Whether you're putting together a fortnight's tour or
just enjoying a few day rides from a single base, this guide is
packed with useful information to help you make the most of your
trip. The Hebridean islands offer a wealth of wonderful scenery:
the majestic Cuillin mountains on Skye; the otherworldly palm trees
on Bute; the marvellous white shell sands on Tiree and Harris. This
guidebook features detailed custom mapping and elevation profiles
for all routes, and comprehensive information of ferry and
transport routes, accommodation, food and drink, supplies, cycle
spares and repairs. Island hopping in these islands is a magical
experience. The guide visits over 20 of them and each has its own
interesting history and wildlife. Reasonably fit cyclists can enjoy
these routes at their own pace; experienced cycle tourists will eat
up the miles.
Values-driven organizations are the most successful organizations
on the planet. This book explains that understanding employees'
needs-what people value-is the key to creating a high performing
organization. When you support employees in satisfying their needs,
they respond with high levels of engagement and willingly commit
their energies to the organization, bringing passion and creativity
to their work. This new edition of The Values-Driven Organization
provides an updated set of tools to assess corporate culture, new
case studies on cultural transformation and additional materials on
sustainability, measuring cultural health at work and the specific
needs of the millennial generation. The Values-Driven Organization
is essential reading for students, researchers and practitioners of
organizational change, leadership, HRM and business ethics.
Tapping into the latent creativity and productivity in an
organizations employees are two of the most important things any
successful business should be concerned with. In a world where
competition has become global, successful companies are learning to
build competitive advantage through their human capital. In
turbulent times, strategic success will also hinge on whether, in
the eyes of the employees and society-at-large, the organization is
a trusted member of the community and a good global citizen.
Developing a values-driven approach to business is quickly becoming
essential for financial success. Who you are and what you stand for
are becoming just as important as what you sell. This bestselling
book presents a convincing rationale for making ethical and
socially responsible behavior the keystone in providing a high
performance, globally successful business.
Planning and Budgeting is one of the hottest topics in accounting;
global spending on budgeting software is booming and is predicted
to continue to grow throughout this decade. It's big business.
This book focuses on 'Driver-Based' budgeting (ie using external
and internal non-financial drivers to predict live item expenses).
The book shows the benefits that Driver-Based Budgeting brings and
as such is a 'tool kit for change'. Case studies and worked
examples are used throughout to ensure understanding, as well as
checklists on implementation issues.
Transform the process of implementing new budgeting software with
Driver-Based Budgeting
Shows how organisations can slash the time and cost involved in
preparing their annual budget
Accountants learn how to manage uncertainty and quickly assess the
impact of both internal and external changes
Richard Barrett, author of the best-selling book Liberating the
Corporate Soul, presents his new thinkingBased on his experience
working with over 1,000 organizations in 32 countries on cultural
transformation for the values-driven organization. He presents a
whole system approach to cultural transformation, showing
organizations how they can change their culture to become
values-driven organizations that support their employees, their
customers, their partners, their leaders, and ultimately drive
effectiveness and profit.
The two most critical issues for business today, according to CEO's
Barrett has worked with, are: "How to tap the deepest levels of
creativity and the highest levels of productivity of our
employees." In a world where competition has become global,
successful companies are learning to build competitive advantage
through their human capital. In the 21st Century, even that will
not be enough. Success will also hinge on whether, in the eyes of
the employees and society-at-large, the organization is a trusted
member of the community and a good global citizen. Developing a
values-driven approach to business is quickly becoming essential
for financial success. Who you are and what you stand for are
becoming just as important as what you sell. "More than simply a
majestic vision, Richard Barrett's book brilliantly describes the
ways and means for business leaders to create the compassionate and
viable future we urgently need on our beautiful planet." -Godric
E.S. Bader, F.R.S.A., Life President, Scott Bader Commonwealth Ltd.
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Facilitative Glucose Transporters in Articular Chondrocytes - Expression, Distribution and Functional Regulation of GLUT Isoforms by Hypoxia, Hypoxia Mimetics, Growth Factors and Pro-Inflammatory Cytokines (Paperback, 2008 ed.)
Ali Mobasheri, Carolyn A. Bondy, Kelle Moley, Alexandrina Ferreira Mendes, Susana Carvalho Rosa, …
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R2,869
Discovery Miles 28 690
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Ships in 10 - 15 working days
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Articular cartilage is a unique and highly specialized avascular
connective tissue in which the availability of oxygen and glucose
is significantly lower than synovial fluid and plasma. Glucose is
an essential source of energy during embryonic growth and fetal
development and is vital for mesenchymal cell differentiation,
chondrogenesis and skeletal morphogenesis. Glucose is an important
metabolic fuel for differentiated chondrocytes during post-natal
development and in adult articular cartilage and is a common
structural precursor for the synthesis of extracellular matrix
glycosaminoglycans. Glucose metabolism is critical for growth plate
chondrocytes which participate in long bone growth. Glucose
concentrations in articular cartilage can fluctuate depending on
age, physical activity and endocrine status. Chondrocytes are
glycolytic cells and must be able to sense the concentration of
oxygen and glucose in the extracellular matrix and respond
appropriately by adjusting cellular metabolism. Consequently
chondrocytes must have the capacity to survive in an extracellular
matrix with limited nutrients and low oxygen tensions. Published
data from our laboratories suggest that chondrocytes express
multiple isoforms of the GLUT/SLC2A family of glucose/polyol
transporters. In other tissues GLUT proteins are expressed in a
cell-specific manner, exhibit distinct kinetic properties, and are
developmentally regulated. Several GLUTs expressed in chondrocytes
are regulated by hypoxia, hypoxia mimetics, metabolic hormones and
pro-inflammatory cytokines. In this multidisciplinary article we
review the molecular and morphological aspects of GLUT expression
and function in chondrocytes and their mesenchymal and embryonic
stem cell precursors and propose key roles for these proteins in
glucose sensing and metabolic regulation in cartilage.
Richard Barrett, author of the best-selling book Liberating the
Corporate Soul, presents his new thinking Based on his experience
working with over 1,000 organizations in 32 countries on cultural
transformation for the values-driven organization. He presents a
whole system approach to cultural transformation, showing
organizations how they can change their culture to become
values-driven organizations that support their employees, their
customers, their partners, their leaders, and ultimately drive
effectiveness and profit.
In diesem Buch ist es Richard Barrett gelungen, das schwer
greifbare Thema "Organisationskultur" auf verbluffend einfache Art
handhabbar zu machen. Er konzentriert sich bei der Kultur-Diagnose
auf Werte - also die Kurzform dessen, was Menschen wichtig ist.
Eindrucksvoll zeigt Barrett, dass eine werteorientierte
Kulturtransformation das Engagement der Mitarbeiter und damit auch
den Ertrag steigert. Die Methodenfamilie CTT (Cultural
Transformation Tools) bietet einerseits Werkzeuge zur Erfassung und
Gestaltung der Organisationskultur mit drei Kennzahlen, die den
Fortschritt der Transformation messbar machen, und andererseits
Werkzeuge zur Erfassung der Leadership Performance, um die
persoenliche Transformation von Fuhrungskraften zu monitoren, denn
Barrett sagt: "Organizations don't change, people do!"
My basic hypothesis is that evolution was never about species, it
was always about consciousness. Therefore, the continuance of 3.8
billion years of evolution on Earth now rests on the shoulders of
the evolution human consciousness. Unlike Neo-Darwinism and
Intelligent Design, which are only concerned with life on Earth,
the evolutionary intelligence theory explains the whole of
evolution from the Big Bang to the present day. Richard Barrett
takes on nothing less than the theory of evolution and adds
immeasurably to our understanding. The elegant simplicity with
which Richard guides us through his ideas is refreshing in this era
of complication and complexity and indicates a rare clarity of
thought. His analysis of current world events and prognosis for the
future should be required reading for all politicians and
policymakers. Ruth Steinholtz, AreteWork LLP
Is Love Life! a plea or a command? Or a mantra to stave off the
panic of sunless Eccles van dreams? Or an exclamation of emotion
recollected in the untranquility of a Promazine afternoon? That big
exclamation mark is important. It's one third of the title. It's
the sustained intensity of 'the infinite MegaBus journey to the
world' of various Gareths, Samsung deletions and poems as messages
pinging out between people (maybe, or maybe not, Lucky Pierre
style). For all your life! death! love! needs, read this book. -
Rachel Sills
his slender book is a rare gift: a distilled compilation of the
most profound insights that the ever-brilliant Richard Barrett has
accumulated over decades of path-breaking work. If every individual
and organisation used Richard's frameworks to guide their actions,
our world would be a blessed place. Raj Sisodia, FW Olin
Distinguished Professor of Global Business, Babson College,
Co-founder & Chairman Emeritus, Conscious Capitalism Inc., USA.
The best book on values I have ever read. Richard Barrett is one of
the world's foremost experts on the subject; nevertheless he
manages to inhabit the 'beginner's mind': He takes us back to the
fundamental truths about the importance of values in our personal,
organisational and societal lives. Ruth Steinholtz, Founder and
Managing Partner of AreteWork LLP, UK.
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