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This reference summarizes the latest research on the structure,
function, and design of synthetic and natural peptide antibiotics,
describing practical applications of these compounds in food
preservation and packaging, and in the prevention and treatment of
infectious diseases by direct anti-bacterial action and as part of
the adaptive immune response.
Peptide Antibiotics discusses these unique compounds and their many
and exciting applications, including:
the distribution and classification of diverse antimicrobial
peptides throughout nature
the role in host defense of mucosal surface peptide antibiotics
such as defensins and cathepsins
the biosynthesis of lanthionine-containing antibiotics including
nisin, epidermin, and mersacidin
the genetic basis determining the production of bacterial peptide
antibiotics
the potential commercial use of magainin, nisin, and lacticin
peptides as anti-infective agents
the use of nisin as a commercial food preservative
With contributions from 19 world-renowned experts in the field,
Peptide Antibiotics is an indispensable source of information for
pharmaceutical scientists, medicinal and organic chemists and
biochemists, microbiologists, infectious disease specialists,
molecular biologists, and upper-level undergraduate and graduate
students in these disciplines.
The enormous genetic flexibility of bacteria jeopardizes the
usefulness of currently available antibiotics, and requires new
approaches to antibiotic discovery and development. Antimicrobial
resistance can be acquired in a short time frame, both by genetic
mutation and by direct transfer of resistance genes across genus
and species boundaries. Understanding mechanisms of resistance is
crucial to the future of antimicrobial therapy. Extensively
revised, with contributions from international leaders in their
fields, Bacterial Resistance to Antimicrobials, Second Edition
blends scientific and practical approaches to the social, economic,
and medical issues related to this growing problem. The book begins
with a history of antimicrobial agents and bacterial resistance,
and outlines the forces that contributed to the abuse of
antibiotics and precipitated the current crisis. It goes on to
describe what is known about the ecology of antibiotic resistant
bacteria and reveals the inadequacies in our understanding.
Emphasizing public health aspects, the editors stress that
significant progress will be made only by addressing the problem
only as a public, worldwide, problem. Chapters on resistance
mechanisms describe the latest findings on what makes different
groups of bacteria susceptible or resistant to antibiotics. They
reveal the staggering diversity of bacteria and the need for a
foundational understanding that will stimulate development of
antibiotics capable of avoiding resistance mechanisms. Examining
the success and limitations of complementary approaches, such as
combining ss-lactam antibiotics with ss-lactamase inhibitors, the
book brings together information on resistance mechanisms in
different groups of bacteria to help future efforts to more
effectively develop and deploy antimicrobial therapies.
The enormous genetic flexibility of bacteria jeopardizes the
usefulness of currently available antibiotics, and requires new
approaches to antibiotic discovery and development. Antimicrobial
resistance can be acquired in a short time frame, both by genetic
mutation and by direct transfer of resistance genes across genus
and species boundaries. Understanding mechanisms of resistance is
crucial to the future of antimicrobial therapy. Extensively
revised, with contributions from international leaders in their
fields, Bacterial Resistance to Antimicrobials, Second Edition
blends scientific and practical approaches to the social, economic,
and medical issues related to this growing problem. The book begins
with a history of antimicrobial agents and bacterial resistance,
and outlines the forces that contributed to the abuse of
antibiotics and precipitated the current crisis. It goes on to
describe what is known about the ecology of antibiotic resistant
bacteria and reveals the inadequacies in our understanding.
Emphasizing public health aspects, the editors stress that
significant progress will be made only by addressing the problem
only as a public, worldwide, problem. Chapters on resistance
mechanisms describe the latest findings on what makes different
groups of bacteria susceptible or resistant to antibiotics. They
reveal the staggering diversity of bacteria and the need for a
foundational understanding that will stimulate development of
antibiotics capable of avoiding resistance mechanisms. Examining
the success and limitations of complementary approaches, such as
combining ss-lactam antibiotics with ss-lactamase inhibitors, the
book brings together information on resistance mechanisms in
different groups of bacteria to help future efforts to more
effectively develop and deploy antimicrobial therapies.
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