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Based on the international workshop GPCRs: From Deorphanisation
to Lead Structure Identification, held in Berlin in May 2006, the
book highlights the following topics: Structure of GPCRs, Design of
GPCR Ligands, GPCR Signalling, Deorphanization and Assay
Development. All chapters are written by leading experts in the
field, discussing the most recent state of the art. They give
insight into the approaches taken by industry and academia to
address GPCRs and depict how mature this target class-oriented
research has become in the last decade. The book reflects the
actual trends in the fast-emerging field of GPCR research in
academia and industry.
In autumn 2002, the Ernst Schering Research Foundation Workshop
sponsored the 45th in its series of conferences devoted to emerging
areas in basic and applied biomedical research. These conferences
bring together a critical mass of top scientists working in an
impor- tant area in an intimate setting that fosters the free
exchange of knowledge and ideas. In this spirit, Workshop 45
assembled leaders in the field of chemokines - hemotactic cytokines
that coordinate leukocyte trafficking - amid the scenic vineyards
and wineries of Napa Valley, to discuss the latest concepts of how
these molecules regulate the immune response and disease.
Chemokines were se- lected as a conference topic because they have
revitalized the study of leukocyte trafficking and are widely
considered to be potential new targets for drug development, in
diseases ranging from acute in- flammation and autoimmunity to HIV
and cancer. Discovered in the 1980s, the chemokine superfamily
currently has 43 human members, making it the largest subset of
cytokines. Mem- bers are defined by conserved sequences and a
common three-di- mensional fold, and can be divided into two major
functional groups - homeostatic and inflammatory - depending on
whether they are produced constitutively, and thereby control basal
lymphocyte traf- ficking, or whether they must be induced, for
example by pathogens or injury, and thereby control deployment of
effector leukocytes in emergencies.
Chemokines are major mediators of immune cells and are involved in
a wide range of proinflammatory human diseases, including
rheumatoid arthritis, multiple sclerosis, and organ transplant
rejection. It has recently been discovered that their receptors are
involved in HIV infection. The characterization of these molecules
and their receptors is thus of primary importance in understanding
a number of human diseases and infections. This volume and its
companion Volume 288 on Chemokine Receptors provide comprehensive
experimental protocols used in this field of research.
Key Features
* C-X-C Chemokines
* C-C and C Chemokines
* Other Methods
In autumn 2002, the Ernst Schering Research Foundation Workshop
sponsored the 45th in its series of conferences devoted to emerging
areas in basic and applied biomedical research. These conferences
bring together a critical mass of top scientists working in an
impor- tant area in an intimate setting that fosters the free
exchange of knowledge and ideas. In this spirit, Workshop 45
assembled leaders in the field of chemokines - hemotactic cytokines
that coordinate leukocyte trafficking - amid the scenic vineyards
and wineries of Napa Valley, to discuss the latest concepts of how
these molecules regulate the immune response and disease.
Chemokines were se- lected as a conference topic because they have
revitalized the study of leukocyte trafficking and are widely
considered to be potential new targets for drug development, in
diseases ranging from acute in- flammation and autoimmunity to HIV
and cancer. Discovered in the 1980s, the chemokine superfamily
currently has 43 human members, making it the largest subset of
cytokines. Mem- bers are defined by conserved sequences and a
common three-di- mensional fold, and can be divided into two major
functional groups - homeostatic and inflammatory - depending on
whether they are produced constitutively, and thereby control basal
lymphocyte traf- ficking, or whether they must be induced, for
example by pathogens or injury, and thereby control deployment of
effector leukocytes in emergencies.
Based on the international workshop GPCRs: From Deorphanisation
to Lead Structure Identification, held in Berlin in May 2006, the
book highlights the following topics: Structure of GPCRs, Design of
GPCR Ligands, GPCR Signalling, Deorphanization and Assay
Development. All chapters are written by leading experts in the
field, discussing the most recent state of the art. They give
insight into the approaches taken by industry and academia to
address GPCRs and depict how mature this target class-oriented
research has become in the last decade. The book reflects the
actual trends in the fast-emerging field of GPCR research in
academia and industry.
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