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Chemokine Roles in Immunoregulation and Disease (Hardcover, 2004 ed.)
Loot Price: R4,478
Discovery Miles 44 780
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Chemokine Roles in Immunoregulation and Disease (Hardcover, 2004 ed.)
Series: Ernst Schering Foundation Symposium Proceedings, 45
Expected to ship within 10 - 15 working days
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In autumn 2002, the Ernst Schering Research Foundation Workshop
sponsored the 45th in its series of conferences devoted to emerging
areas in basic and applied biomedical research. These conferences
bring together a critical mass of top scientists working in an
impor- tant area in an intimate setting that fosters the free
exchange of knowledge and ideas. In this spirit, Workshop 45
assembled leaders in the field of chemokines - hemotactic cytokines
that coordinate leukocyte trafficking - amid the scenic vineyards
and wineries of Napa Valley, to discuss the latest concepts of how
these molecules regulate the immune response and disease.
Chemokines were se- lected as a conference topic because they have
revitalized the study of leukocyte trafficking and are widely
considered to be potential new targets for drug development, in
diseases ranging from acute in- flammation and autoimmunity to HIV
and cancer. Discovered in the 1980s, the chemokine superfamily
currently has 43 human members, making it the largest subset of
cytokines. Mem- bers are defined by conserved sequences and a
common three-di- mensional fold, and can be divided into two major
functional groups - homeostatic and inflammatory - depending on
whether they are produced constitutively, and thereby control basal
lymphocyte traf- ficking, or whether they must be induced, for
example by pathogens or injury, and thereby control deployment of
effector leukocytes in emergencies.
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