Design and Analysis of Clinical Trials for Predictive Medicine provides statistical guidance on conducting clinical trials for predictive medicine. It covers statistical topics relevant to the main clinical research phases for developing molecular diagnostics and therapeutics-from identifying molecular biomarkers using DNA microarrays to confirming their clinical utility in randomized clinical trials. The foundation of modern clinical trials was laid many years before modern developments in biotechnology and genomics. Drug development in many diseases is now shifting to molecularly targeted treatment. Confronted with such a major break in the evolution toward personalized or predictive medicine, the methodologies for design and analysis of clinical trials is now evolving. This book is one of the first attempts to contribute to this evolution by laying a foundation for the use of appropriate statistical designs and methods in future clinical trials for predictive medicine. It is a useful resource for clinical biostatisticians, researchers focusing on predictive medicine, clinical investigators, translational scientists, and graduate biostatistics students.

Design and Analysis of Clinical Trials for Predictive Medicine provides statistical guidance on conducting clinical trials for predictive medicine. It covers statistical topics relevant to the main clinical research phases for developing molecular diagnostics and therapeutics-from identifying molecular biomarkers using DNA microarrays to confirming their clinical utility in randomized clinical trials. The foundation of modern clinical trials was laid many years before modern developments in biotechnology and genomics. Drug development in many diseases is now shifting to molecularly targeted treatment. Confronted with such a major break in the evolution toward personalized or predictive medicine, the methodologies for design and analysis of clinical trials is now evolving. This book is one of the first attempts to contribute to this evolution by laying a foundation for the use of appropriate statistical designs and methods in future clinical trials for predictive medicine. It is a useful resource for clinical biostatisticians, researchers focusing on predictive medicine, clinical investigators, translational scientists, and graduate biostatistics students.

This is a practical guide to policing domestic violence in the United Kingdom. It sets out approaches to help identify victims early and target offenders through the effective use of intelligence across a range of offending. It also offers guidance on investigative techniques, risk assessment, inter-agency murder reviews and information-sharing. The impact of domestic violence on children and other witnesses is discussed, and the powers available to police under new legislation are outlined.
This title provides officers with information on all the practical measures to protect victims through the civil courts and through inter-agency schemes and perpetrator programs in the UK. It also includes a chapter on the topical subject of honor-based violence and forced marriage and gives advice on the various measures officers can take. All the issues covered in the book are supplemented with useful case studies and checklists, as well as examples of log taking and relevant forms, illustrating how the issues are dealt with in practice.
The book forms part of the Blackstone's Practical Policing Series. The series, aimed at junior to middle ranking officers, consists of practical guides containing clear and detailed explanations of the relevant legislation and practice, accompanied by case studies, illustrative diagrams and useful checklists.

Political devil. The Judas Iscariot of Oregon politics. Little Napoleon. Those are among the terms used to describe Joseph Simon, the nation's first Jewish Republican senator. Oregon's Boss Simon was a machine politician who hobnobbed with U.S. presidents. But he had an ugly falling out with Teddy Roosevelt, accusing the president of discriminating against him because he was Jewish. The author had heard about his famous relative. But no one in the family knew much about Senator Simon. So, Richard Simon, a former congressional correspondent for the Los Angeles Times, looked into Senator Simon's life. What he discovered was a man described as ?worse than a Southern Pacific train robber.? Joe Simon's election to the U.S. Senate was called ?one of the greatest political surprises ever. Simon, an attorney for powerful railroads, played a critical role in the development of the Pacific Northwest.

This scarce antiquarian book is a selection from Kessinger PublishingA AcentsAcentsa A-Acentsa Acentss Legacy Reprint Series. Due to its age, it may contain imperfections such as marks, notations, marginalia and flawed pages. Because we believe this work is culturally important, we have made it available as part of our commitment to protecting, preserving, and promoting the world's literature. Kessinger Publishing is the place to find hundreds of thousands of rare and hard-to-find books with something of intere

This scarce antiquarian book is a selection from Kessinger PublishingA AcentsAcentsa A-Acentsa Acentss Legacy Reprint Series. Due to its age, it may contain imperfections such as marks, notations, marginalia and flawed pages. Because we believe this work is culturally important, we have made it available as part of our commitment to protecting, preserving, and promoting the world's literature. Kessinger Publishing is the place to find hundreds of thousands of rare and hard-to-find books with something of intere

Due to the very old age and scarcity of this book, many of the pages may be hard to read due to the blurring of the original text, possible missing pages, missing text and other issues beyond our control.