Design and Analysis of Clinical Trials for Predictive Medicine provides statistical guidance on conducting clinical trials for predictive medicine. It covers statistical topics relevant to the main clinical research phases for developing molecular diagnostics and therapeutics-from identifying molecular biomarkers using DNA microarrays to confirming their clinical utility in randomized clinical trials. The foundation of modern clinical trials was laid many years before modern developments in biotechnology and genomics. Drug development in many diseases is now shifting to molecularly targeted treatment. Confronted with such a major break in the evolution toward personalized or predictive medicine, the methodologies for design and analysis of clinical trials is now evolving. This book is one of the first attempts to contribute to this evolution by laying a foundation for the use of appropriate statistical designs and methods in future clinical trials for predictive medicine. It is a useful resource for clinical biostatisticians, researchers focusing on predictive medicine, clinical investigators, translational scientists, and graduate biostatistics students.

Design and Analysis of Clinical Trials for Predictive Medicine provides statistical guidance on conducting clinical trials for predictive medicine. It covers statistical topics relevant to the main clinical research phases for developing molecular diagnostics and therapeutics-from identifying molecular biomarkers using DNA microarrays to confirming their clinical utility in randomized clinical trials. The foundation of modern clinical trials was laid many years before modern developments in biotechnology and genomics. Drug development in many diseases is now shifting to molecularly targeted treatment. Confronted with such a major break in the evolution toward personalized or predictive medicine, the methodologies for design and analysis of clinical trials is now evolving. This book is one of the first attempts to contribute to this evolution by laying a foundation for the use of appropriate statistical designs and methods in future clinical trials for predictive medicine. It is a useful resource for clinical biostatisticians, researchers focusing on predictive medicine, clinical investigators, translational scientists, and graduate biostatistics students.

Learning Medicine is a must-read for anyone thinking of a career in medicine, or who is already in the training process and wants to understand and explore the various options and alternatives along the way. Whatever your background, whether you are school-leaver or mature student, if you are interested in finding out more about becoming and being a good doctor, this is the book for you. In continuous publication since 1983, and now in its eighteenth edition, Learning Medicine provides the most current, honest and informative source of essential knowledge combined with pragmatic guidance. Learning Medicine describes medical school courses, explains foundation years and outlines the wide range of speciality choices allowing tomorrow's doctors to decide about their future careers; but it also goes further to consider the privilege and responsibility of being a doctor, providing food for thought and reflection throughout a long and rewarding career.

Political devil. The Judas Iscariot of Oregon politics. Little Napoleon. Those are among the terms used to describe Joseph Simon, the nation's first Jewish Republican senator. Oregon's Boss Simon was a machine politician who hobnobbed with U.S. presidents. But he had an ugly falling out with Teddy Roosevelt, accusing the president of discriminating against him because he was Jewish. The author had heard about his famous relative. But no one in the family knew much about Senator Simon. So, Richard Simon, a former congressional correspondent for the Los Angeles Times, looked into Senator Simon's life. What he discovered was a man described as ?worse than a Southern Pacific train robber.? Joe Simon's election to the U.S. Senate was called ?one of the greatest political surprises ever. Simon, an attorney for powerful railroads, played a critical role in the development of the Pacific Northwest.

This scarce antiquarian book is a selection from Kessinger PublishingA AcentsAcentsa A-Acentsa Acentss Legacy Reprint Series. Due to its age, it may contain imperfections such as marks, notations, marginalia and flawed pages. Because we believe this work is culturally important, we have made it available as part of our commitment to protecting, preserving, and promoting the world's literature. Kessinger Publishing is the place to find hundreds of thousands of rare and hard-to-find books with something of intere

This scarce antiquarian book is a selection from Kessinger PublishingA AcentsAcentsa A-Acentsa Acentss Legacy Reprint Series. Due to its age, it may contain imperfections such as marks, notations, marginalia and flawed pages. Because we believe this work is culturally important, we have made it available as part of our commitment to protecting, preserving, and promoting the world's literature. Kessinger Publishing is the place to find hundreds of thousands of rare and hard-to-find books with something of intere

Due to the very old age and scarcity of this book, many of the pages may be hard to read due to the blurring of the original text, possible missing pages, missing text and other issues beyond our control.