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It is estimated that 80 to 90% of drugs under development never
make it to the marketplace due to insufficient clinical activity,
unacceptable toxicity, rapid appearance of drug resistance, or
other factors that should be, at least partially, predictable from
preclinical testing. This new text asks the question, "How can we
use computational methods to improve the success rate in drug
development?" Computer Techniques in Preclinical and Clinical Drug
Development shows how modeling makes it possible to extract the
maximum amount of information and predictive value from preclinical
data. Computer modeling methods from the areas of pharmacokinetics,
pharmacodynamics, cytokinetics, and inhibition kinetics of
multi-enzyme pathways are all discussed in this unique reference
source.
Visually stunning, informative, and broad in scope, this
comprehensive overview gathers the works of renowned still-life
painter Scott Fraser. Beautiful full color images of his body of
work are accompanied by companion drawings and detailed close-ups,
demonstrating the artist's approach to painting. A summary of his
work, an interview of Fraser by artist Robert C. Jackson, and an
extensive chronology of works allow the reader to explore the path
of growth and development that took him from a landscape painter in
the 1980s to the nationally renowned still-life painter that Fraser
is today. His intense scrutiny of objects is revealed in full-page
details of several important works. The over 200 drawings and
paintings included here also reveal how Fraser's passion for art
history is a strongly recurring theme, often demonstrating itself
in surprising ways. This book offers valuable insights for
collectors, museums, students, academics, artists, and everyone
interested in contemporary still life painting.
It is estimated that 80 to 90% of drugs under development never
make it to the marketplace due to insufficient clinical activity,
unacceptable toxicity, rapid appearance of drug resistance, or
other factors that should be, at least partially, predictable from
preclinical testing. This new text asks the question, "How can we
use computational methods to improve the success rate in drug
development?" Computer Techniques in Preclinical and Clinical Drug
Development shows how modeling makes it possible to extract the
maximum amount of information and predictive value from preclinical
data. Computer modeling methods from the areas of pharmacokinetics,
pharmacodynamics, cytokinetics, and inhibition kinetics of
multi-enzyme pathways are all discussed in this unique reference
source.
Advances in cancer genomics are transforming our understanding of
cancer, and have profound implications for its prevention,
diagnosis, and treatment. Evolutionary dynamics suggests that as
few as two mutations can cause transformation of normal cells into
cancer stem cells. A process of Darwinian selection, involving a
further three or more mutations, taking place over a period of
years, can then result in progression to a life-threatening tumour.
In many cases the immune response can recognise and eliminate the
mutant cells, but most advanced tumours have mutations that
activate immune checkpoints and enable the tumour to hide from the
immune system. For the most hard-to-treat tumours, future progress
will require molecular diagnostics to detect cancer-causing
mutations in healthy subjects, and new drugs or vaccines that
prevent the progression process. Chapters of this book deal with
the signalling pathways that control cell division, and changes in
these pathways in cancer cells. Three cell cycle checkpoints that
are often mutated in cancer are analysed in detail. A discussion of
chronic myeloid leukaemia illustrates the role of reactive oxygen
species in driving progression from a chronic to an acute
condition. A single drug that suppresses reactive oxygen can
prevent disease progression and turn an otherwise deadly disease
into a condition that can be managed to enable many years of normal
life. Another chapter discusses chronic myelomonocytic leukaemia, a
disease that involves both genetic and epigenetic change. Tumour
progression is discussed as a multi-stage process in which cancer
stem cells evolve into genetically unstable, invasive, metastatic,
drug-resistant growths. Each of these stages can act as targets for
drugs or immunomodulators, but the future of cancer treatment lies
in understanding tumour dynamics, and arresting malignancy at the
earliest possible stage. Evolutionary dynamics is a primarily
mathematical technique, but the target readership will be tumour
biologists, clinicians, and drug developers. Computational detail
is provided in an online supplement, but the main text emphasises
the implications of the dynamics for an understanding of tumour
biology and does not require mathematical expertise.
Most art books are not in the first person, so while there is some
truth to the analyses, some things are always off. Robert C.
Jackson set out to interview 20 contemporary representational
artists (himself included) and showcase their artwork within the
context of their interviews. Here you will meet Steven Assael, Bo
Bartlett, Debra Bermingham, Margaret Bowland, Paul Fenniak, Scott
Fraser, Woody Gwyn, F. Scott Hess, Laurie Hogin, Robert C. Jackson,
Alan Magee, Janet Monafo, John Moore, Charles Pfahl, Scott Prior,
Stone Roberts, Sandra Mendelsohn Rubin, Daniel Sprick, Will Wilson,
and Jerome Witkin. Each of these artists has a very elusive quality
a unique voice. Seeing their work from across a room they are all
recognizable. Their artworks are showcased in this large book with
more than 140 images of their paintings as well as photographs of
the artists in their studios and an epilogue by Pamela Sienna."
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