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Unparalleled in scope and content, Surgical Pathology of the
GI Tract, Liver, Biliary Tract and Pancreas provides the most
relevant and up-to-date clinical, etiologic, molecular, and
therapeutic management information for surgical pathologists
in training and in practice. The fully revised 4th Edition of this
award-winning title offers a wealth of information in this
fast-changing field, including recent advances in molecular biology
and immunohistochemistry, in a clearly written,
well-structured manner that is easy to read and
navigate. This one-stop reference for the entire gastrointestinal
system enables you to improve turnaround time when diagnosing a
specimen and to clearly report on the prognosis and therapeutic
management options to surgical and medical colleagues. Covers the
latest developments in molecular technologies and
immunohistochemical markers to provide useful diagnostic and
prognostic information and inform therapeutic decisions.Â
Provides all the necessary tools to make a comprehensive
diagnostic workup, including data from ancillary techniques and
molecular findings whenever appropriate.Â
Incorporates more than 3000 high-quality color
illustrations to help you recognize and diagnose any tissue
sample under the microscope. Reviews next-generation
sequencing (NGS)Â to help identify targetable mutations in
gastrointestinal tract tumors and provide more accurate
classification and precision therapies.Â
Features extensive tables, graphs, and flowcharts to
help you effectively grasp complex topics and streamline your
decision-making. Helps you avoid diagnostic errors
with practical advice on pitfalls in differential
diagnosis. Incorporates the latest WHO
guidelines throughout. Winner of the 2015 BMA Medical
Book Awards First Prize Award in Pathology. Enhanced eBook
version included with purchase. Your enhanced eBook allows
you to access an image bank, as well as all of the
text, figures, and references from the book on a variety of
devices.
Since the publication of the previous edition of Tumors of the
Esophagus and Stomach, great advances in many areas of tumor
biology have led to a better understanding of the pathogenesis,
pathology, and molecular biology of epithelial and stromal
malignancies of the upper gastrointestinal tract. Many of these
advances have led to specific improvements in diagnosis, prognosis,
treatment, and thus, survival in patients affected by these tumors.
This edition of the Fascicle was written to highlight these
advances, and more specifically, to help pathologists diagnose
diseases more accurately and understand how pathology contributes
to clinical treatment in the new age of personalized and targeted
therapy. Notable advances described in this publication include: 1)
expansion of our understanding of the pathologic features and
molecular pathogenesis of carcinomas of the esophagus and stomach,
most of which develop through a chronic
inflammation-metaplasia-dysplasia-carcinoma sequence. Important
refinements in the classification of neoplastic precursor lesions
have been made since the last AFIP series, including the
morphologic and endoscopic subtypes, and this has led to
improvements in surgical treatment with a strong trend toward
minimization in the form of endoscopic mucosal and submucosal
dissections 2) discovery of new diseases, such as gastric
adenocarcinoma and proximal polyposis syndrome (GAPPS), a special
variant of familial adenomatous polyposis, and significant advances
in our knowledge regarding the molecular characterization of
genetic polyposis syndromes 3) great expansion in the
molecular-pathology correlation, morphologic diversity,
classification, and therapeutic options of gastrointestinal stromal
tumors (GISTs) 4) reclassification and refinement of prognostic
factors related to neuroendocrine tumors 5) improvements in the
role of cytology in the diagnosis of tumors of the upper
gastrointestinal tract. This book has been written with the
pathologist in mind first by using tables that illustrate salient
pathologic, molecular, and differential diagnostic features of key
entities that are often difficult to distinguish from each other.
Specific color photographs of classic tumors and morphologic
variants often difficult to recognize are used throughout.
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