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Inflammation has invaded the field of psychiatry. The finding that
cytokines are elevated in various affective and psychotic disorders
brings to the forefront the necessity of identifying the precise
research domain criteria (RDoCs) that inflammation is responsible
for. This task is certainly the most advanced in major depressive
disorders. The reason is that a dearth of clinical and preclinical
studies has demonstrated that inflammation can cause symptoms of
depression and conversely, cytokine antagonists can attenuate
symptoms of depression in medical and psychiatric patients with
chronic low grade inflammation. Important knowledge has been gained
on the symptom dimensions that inflammation is driving and the
mechanisms of action of cytokines in the brain, providing new
targets for drug research and development. The aim of the book
"Inflammation-Associated Depression" is to present this field of
research and its implications in a didactic and comprehensive
manner to basic and clinical scientists, psychiatrists, physicians,
and students at the graduate level.
Inflammation has invaded the field of psychiatry. The finding that
cytokines are elevated in various affective and psychotic disorders
brings to the forefront the necessity of identifying the precise
research domain criteria (RDoCs) that inflammation is responsible
for. This task is certainly the most advanced in major depressive
disorders. The reason is that a dearth of clinical and preclinical
studies has demonstrated that inflammation can cause symptoms of
depression and conversely, cytokine antagonists can attenuate
symptoms of depression in medical and psychiatric patients with
chronic low grade inflammation. Important knowledge has been gained
on the symptom dimensions that inflammation is driving and the
mechanisms of action of cytokines in the brain, providing new
targets for drug research and development. The aim of the book
"Inflammation-Associated Depression" is to present this field of
research and its implications in a didactic and comprehensive
manner to basic and clinical scientists, psychiatrists, physicians,
and students at the graduate level.
Cytokines had been characterized in the early eighties as
communication mole cules between immune cells, and between
immunocytes and other peripheral cells, such as fibroblasts and
endothelial cells. They play a key role in the regulation of the
immune response and the coordination of the host response to
infection. Based on these biological properties, nobody would have
predicted that one decade later cytokines would burst upon
neurosciences and permeate into several avenues of current
research. In neurology, the connection between cytokines and
inflammation, and the demonstration of a pivotal role of some of
these molecules in cell death by apoptosis, prompted the
investigation of their involvement in several neurological diseases
involving an inflammatory component, including multiple sclerosis,
brain trauma, stroke, and Alzheimer's disease. This movement
started in the late eighties, and the corresponding field of
research, known as neuroimmunology, is presently booming. In
psychiatry, however, the relationship between cytokines and mental
disorders was much less evident and took longer to materialize. The
first indication that cytokines might be involved in
psychopathology came from cancerology and internal medicine."
Cytokines had been characterized in the early eighties as
communication mole cules between immune cells, and between
immunocytes and other peripheral cells, such as fibroblasts and
endothelial cells. They play a key role in the regulation of the
immune response and the coordination of the host response to
infection. Based on these biological properties, nobody would have
predicted that one decade later cytokines would burst upon
neurosciences and permeate into several avenues of current
research. In neurology, the connection between cytokines and
inflammation, and the demonstration of a pivotal role of some of
these molecules in cell death by apoptosis, prompted the
investigation of their involvement in several neurological diseases
involving an inflammatory component, including multiple sclerosis,
brain trauma, stroke, and Alzheimer's disease. This movement
started in the late eighties, and the corresponding field of
research, known as neuroimmunology, is presently booming. In
psychiatry, however, the relationship between cytokines and mental
disorders was much less evident and took longer to materialize. The
first indication that cytokines might be involved in
psychopathology came from cancerology and internal medicine."
The rapidly growing field of immunopsychiatry combines expertise
and insights from immunology, psychiatry and neuroscience to
understand the role of inflammation and other immune processes in
causing and treating mental illness. This represents a major shift
in mental health science, traditionally focused on psychological
and neuronal mechanisms of depression, psychosis and dementia. This
book provides the first comprehensive overview of recent,
inter-disciplinary research linking disordered function of the
immune system to the brain and mental illness. It offers a broad
and deep perspective on the implications of immune system
involvement in psychiatric disorders, including a balanced focus on
basic science and clinical applications. Chapters cover the
scientific evidence linking immune processes to major mental
illnesses such as schizophrenia, depression, anxiety and dementia.
An invaluable guide for graduate students, doctors in training,
scientific researchers and others interested in the link between
the immune system and mental health.
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