Comic fantasy adventure for the family. When the Pearson family goes to stay in a holiday house in rural Maine, the children discover to their surprise that the house is already occupied - by an alien. Before they know it they are under attack from an army of knee-high alien invaders with world-destroying ambitions. Can they save their parents and the rest of the world from annihilation before bedtime?

Topher Grace, Teresa Palmer and Anna Faris star in this coming-of-age comedy drama set in the late 1980s. Matt Franklin (Grace) is a bright young college graduate whose life has been going steadily nowhere since he left college, despite the economic boom going on all around him. When he finds himself at a Labour Day weekend party with Tori (Palmer), the long-time object of his unrequited affections, Matt throws caution to the wind and goes all out to catch the girl of his dreams, whatever it takes.

The discovery and genetic engineering of fluorescent proteins has revolutionized cell biology. What was previously invisible in the cell often can be made visible with the use of fluorescent proteins. In Vivo Cellular Imaging Using Fluorescent Proteins: Methods and Protocols presents state-of-the-art research that has contributed to the fluorescent protein revolution to visualize biological processes in the live animal. This volume covers an array of topics from the employment of the chick CAM model using fluorescent proteins and other fluorescent probes, to intravital fluorescent imaging, as well as 3-dimensional imaging, and design instructions on how to create new and improved far-red and infrared fluorescent proteins, to name a few. Written in the successful Methods in Molecular Biology (TM) series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible protocols, and notes on troubleshooting and avoiding known pitfalls. Authoritative and easily accessible, In Vivo Cellular Imaging Using Fluorescent Proteins: Methods and Protocols is the first volume in the new field of in vivo cell biology and it serves both professionals and novices with its well-honed methodologies.

This volume explores the evolution of bacterial cancer therapy and describes the modern techniques used in therapy today. The chapters in this book cover a broad range of topics such as the development of tumor-targeting Salmonella typhimurium A1-R, a microfluidic device for precise quantification of the interactions between tumor-targeting bacteria and tumor tissue, non-invasive in vivo imaging of bacteria-mediated cancer therapy using bio-luminescent bacteria, methods to achieve remote-control of therapeutic gene expression in tumor-targeting bacteria, and cell-cycle decoy of cancer cells resistant to cytotoxic drugs to drug sensitivity by S. typhimurium A1-R. This book concludes with a chapter on the future potential of bacterial therapy of cancer. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Thorough and informative, Bacterial Therapy of Cancer: Methods and Protocols is a valuable resource for anyone who is interested in cancer and bacterial therapy.

Reports of people rejecting political authority, assaulting it with words and often violent acts, are actions that are part of modern life. Anarchism has been considered a dead movement of the nineteenth and early twentieth century, but it assumed a renewed and substantial relevance in the late twentieth century. Robert Hoffman points out in his incisive Introduction that anarchists have always been viewed either as foolish idealists or, at the other extreme, as serious threats to justice and social tranquility. But, the editor argues, most anarchists have been ordinary people who have shared a singular passion for what they believe to be a just society.

To clarify widespread misconceptions about anarchism, this volume offers a lively debate on the subject, consisting of works by both advocates of anarchism and people who take it seriously but reject it. Represented here, in the writings of Pierre-Joseph Proudhon, Leo Tolstoy, George Bernard Shaw, Bertrand Russell, and others, are different types, styles, and periods of anarchist writing, reflecting a rich variety of thought arising from the anarchist perspective. The essays deal with many of the different strands of anarchists, including anarchist attacks on democracy, patriotism, and military conscription, and provide an outline of the movement's tumultuous history. Against these are set pieces that argue anarchism's impossibility and estimate its relevance to social change.

The debate format of "Anarchism" introduces the reader to a fresh perspective and understanding of vital issues of political and social theory, and provokes him to examine his own thinking. Looking at both sides of the controversy, this volume discourages unquestioning or over-confident opinions. Although the anarchist credo that man can live without government is difficult or impossible for most people to accept, as long as we find it difficult to live within the framework of government control, the influence and potential appeal of anarchist thought will continue to be felt.

Derived from the definitive guide to medical toxicology, this hands-on companion provides accurate information for diagnosing and treating poisoned patients on the spot After more than a decade on the market, Goldfrank’s Toxicologic Emergencies has established itself as the go-to reference for medical toxicology—and this companion manual distills the most important information into a portable, easy-to-navigate resource. Goldfrank’s Manual of Toxicologic Emergencies distills critical information into short summaries and synopses, so you can use it to treat patients in clinical settings or for quick review of critical topics. Fully updated to ensure all information is completely current, this new edition is filled with tables, figures, images, and other visuals to make finding the right answers quick and easy. Each chapter is a direct distillation of the corresponding chapter in Goldfrank’s Toxicologic Emergencies. Whether you’re a medical toxicologist, pharmacist, physician, nurse practitioner, or student, Goldfrank’s Manual of Toxicologic Emergencies provides all the right answers where and when you need them. Covers the full range of xenobiotics: Includes pharmaceuticals, recreational drugs, and substances of abuse; food and plant toxins; envenomations; household toxins; pesticides and herbicides; rodenticides; metals; poison gases; and environmental toxins Systematically reviews toxicokinetics, pathophysiology, clinical manifestations, diagnostic testing, and management for each xenobiotic Provides "Antidotes in Brief"—at-a-glance guides to specific antidotes and their primary applications Authoritative answers at your fingertips: How to manage the poisoned or overdosed patient What techniques effectively eliminate toxins Which imaging modalities yield the best results

This volume explores the evolution of bacterial cancer therapy and describes the modern techniques used in therapy today. The chapters in this book cover a broad range of topics such as the development of tumor-targeting Salmonella typhimurium A1-R, a microfluidic device for precise quantification of the interactions between tumor-targeting bacteria and tumor tissue, non-invasive in vivo imaging of bacteria-mediated cancer therapy using bio-luminescent bacteria, methods to achieve remote-control of therapeutic gene expression in tumor-targeting bacteria, and cell-cycle decoy of cancer cells resistant to cytotoxic drugs to drug sensitivity by S. typhimurium A1-R. This book concludes with a chapter on the future potential of bacterial therapy of cancer. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Thorough and informative, Bacterial Therapy of Cancer: Methods and Protocols is a valuable resource for anyone who is interested in cancer and bacterial therapy.

The best edition yet of the landmark text in medical toxicology Covering every aspect of poison management, this indispensable case-based resource has been thoroughly refreshed to deliver evidence-based principles viewed through the lens of an active bedside clinical practice. In no other reference will you find such a diverse roster of esteemed editors and authors who deliver expert insights into every type of toxicologic emergency, whether due to substance abuse or exposure to toxins. Fully referenced and supported by a cohesive organization and full-color format, Goldfrank's begins with a historical perspective on medical toxicology principles and the general approach to the patient. It then progresses to the fundamental principles of medical toxicology, encompassing biochemical and molecular concepts; the effect of xenobiotics on vital organs and body systems; and toxicologic principles in special populations. The Eleventh Edition of Goldfrank's Toxicologic Emergencies is the most rigorous volume to date, driven by a precise analysis of the latest medical literature and complex cases designed to facilitate differential diagnosis. New to this Edition: *Additional cases and "Special Considerations" chapters designed to enhance clinical decision-making and patient outcomes*New "Antidotes in Depth" provides timely, critical information on toxicologic treatment strategies *New content on toxicogenomics explores its increasingly important role in predictive toxicology*Chapter-ending bulleted summaries of key points *Updated coverage of synthetics such as "K2" *Revised chapters on medical, clinical, and chemical toxicology include updated insights on poison emergencies, treatment strategies, and risk assessment tools

Reports of people rejecting political authority, assaulting it with words and often violent acts, are actions that are part of modern life. Anarchism has been considered a dead movement of the nineteenth and early twentieth century, but it assumed a renewed and substantial relevance in the late twentieth century. Robert Hoffman points out in his incisive Introduction that anarchists have always been viewed either as foolish idealists or, at the other extreme, as serious threats to justice and social tranquility. But, the editor argues, most anarchists have been ordinary people who have shared a singular passion for what they believe to be a just society. To clarify widespread misconceptions about anarchism, this volume offers a lively debate on the subject, consisting of works by both advocates of anarchism and people who take it seriously but reject it. Represented here, in the writings of Pierre-Joseph Proudhon, Leo Tolstoy, George Bernard Shaw, Bertrand Russell, and others, are different types, styles, and periods of anarchist writing, reflecting a rich variety of thought arising from the anarchist perspective. The essays deal with many of the different strands of anarchists, including anarchist attacks on democracy, patriotism, and military conscription, and provide an outline of the movement's tumultuous history. Against these are set pieces that argue anarchism's impossibility and estimate its relevance to social change. The debate format of Anarchism introduces the reader to a fresh perspective and understanding of vital issues of political and social theory, and provokes him to examine his own thinking. Looking at both sides of the controversy, this volume discourages unquestioning or over-confident opinions. Although the anarchist credo that man can live without government is difficult or impossible for most people to accept, as long as we find it difficult to live within the framework of government control, the influence and potential appeal of anarchist thought will continue to be felt.

"Meeting Excellence" is a comprehensive resource that provides a wide range of ready-to-use tools that have been developed and tested by a meeting initiative within Novartis Pharmaceuticals. It is based on years of research observing team meetings, examining existing meeting documents, and conducting a number of intensive individual interviews in the U.S. and Europe. This important book offers the information and tools needed to prepare, facilitate, and follow up on all your meetings. Step by step, "Meeting Excellence" shows how to Create an action-focused meeting agenda Ensure that everyone participates in discussion Deal with disruptive and inattentive people Develop a climate of trust among meeting participants Create and deliver effective meeting presentations Stay on track to achieve your meeting goals Achieve clear communication during a multicultural meetingLiven up a dreary and unproductive meetingClose your meeting on an upbeat and positive noteGet action on team action items Improve meeting communications with line managementEvaluate your meeting quickly and effectivelyChoose among various web-based meeting tools

The discovery and genetic engineering of fluorescent proteins has revolutionized cell biology. What was previously invisible in the cell often can be made visible with the use of fluorescent proteins. In Vivo Cellular Imaging Using Fluorescent Proteins: Methods and Protocols presents state-of-the-art research that has contributed to the fluorescent protein revolution to visualize biological processes in the live animal. This volume covers an array of topics from the employment of the chick CAM model using fluorescent proteins and other fluorescent probes, to intravital fluorescent imaging, as well as 3-dimensional imaging, and design instructions on how to create new and improved far-red and infrared fluorescent proteins, to name a few. Written in the successful Methods in Molecular Biology (TM) series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible protocols, and notes on troubleshooting and avoiding known pitfalls. Authoritative and easily accessible, In Vivo Cellular Imaging Using Fluorescent Proteins: Methods and Protocols is the first volume in the new field of in vivo cell biology and it serves both professionals and novices with its well-honed methodologies.

The hands-on study companion for the most respected, rigorous medical toxicology text available-with 1,400 practice questions/answers Goldfrank's Toxicologic Emergencies has long been the go-to guide for accurately diagnosing and effectively treating poisoned and overdosed patients. Now, this practical companion provides everything you need to get even more out of Goldfrank's. Study Guide for Goldfrank's Toxicologic Emergencies provides 1,400 questions/answers for testing your knowledge-a process that increases information retention and serves as invaluable practice for board exams. Each chapter has its own question set using both general factual and case-based questions. Study Guide for Goldfrank's Toxicologic Emergencies covers: General approach to the poisoned patient Principles of medical toxicology Clinical basis of medical toxicology Poison prevention and education Research principles Legal and forensic considerations

Valor Infinity: The Role-Playing Game,the brainchild of Rob Hoffman and Mike Avery, is a futuristic science fiction/fantasy tabletop Role-Playing Game that takes place in the Pendulum System centered on a planet named Evander. The game focuses on a variety of human and alien species that respond to an emergency distress beacon to find a mysterious planet that is ripe for colonization. The game blends old world fantasy, steampunk societies, and technologically advanced space organizations into a seamless role-playing experience.

15 Shady Poems and a Love Sonnet is a celebration of all things sexy and romantic. Whether you're looking for a naughty tale from Shahrazad or something from the heavens, these shady poems are a treat. Read them alone or with a loved one by the fire place or with someone you just met - do they do that anymore? Poet Robert Hoffman has included Shakespeare's Sonnet 18 for those awkward moments we've all experienced when it would be nice to tell our lovers how they compare to a summer's day.

Thousands of years into the future a solitary distress beacon broadcasts throughout the Pendulum System desperately asking for help. The broadcast leads dozens of human and alien races to a huge, largely uninhabited planet called Evander. A long abandoned super city spans the equator of the planet hiding advanced technology and a multitude of resources. For many Evander is a new beginning, for others it is a potential payday and another planet to exploit, for all it is a hazardous journey that can bring unlimited success or severe misfortune. Do you have what it takes to survive and thrive or will you be another footnote in the success of other adventurers?

This text is designed for a one-semester non-technical introduction to the mathematics of finance. Topics include: interest, inflation, retirements, annuities, mortgages, taxes, credit cards, leases, stocks and bonds, and other investments.

A contemporary poetic review on life observations and experiences. A poetic diary, if you will, of a continuous life.

Strategies for Curative Fluorescence-Guided Surgery of Cancer is the first book to discuss how fluorescence-guided surgery can be successfully used during surgeries with several tumor types. FGS is one of the most exciting emerging modalities of surgery, especially cancer surgery, as it potentially allows the surgeon to visualize the actual margin of the tumor, thus greatly increasing the possibility of curative resection. The book discusses the applicability of FGS for several types of cancer, such as pancreatic cancer, liver metastasis, soft-tissue sarcoma, glioma, melanoma, and breast and lung cancer. This book is a valuable resource for cancer surgeons, cancer researchers and members of several other areas in the biomedical field who are interested in understanding this powerful technique.

When facing threats of violence and terrorism, law enforcement officers are often critical first responders. The ability of these officers to be alert, physically ready, and mentally prepared to handle the hazardous situations that are a regular part of the profession is essential to their agencies and the communities they protect. Fit for Duty, Third Edition With Online Video, provides practical information on creating and implementing physical fitness and wellness programs to help law enforcement officers fulfill their demanding job requirements. Authors Robert Hoffman and Thomas R. Collingwood offer a comprehensive resource with job-specific training and strategies supported by more than 60 years of experience helping law enforcement officers achieve physical fitness and lead healthier lives. Now fully updated with current statistics, anecdotes, and research from agencies across North America, Fit for Duty, Third Edition, contains the following: * Expanded content on physical readiness that provides guidelines and helps readers understand how their fitness affects their ability to perform * A new chapter on nontraditional training that provides instruction on incorporating stability and medicine ball exercises, circuit training, plyometrics, Pilates, and yoga into exercise routines * Accompanying online video that demonstrates 40 test protocols and exercises, showing officers how to properly perform the recommended activities * Reproducible checklists and forms that make instruction easy and allow officers to incorporate fitness into daily routines * An image bank that contains all the forms, figures, tables, and technique photos from the book Fit for Duty, Third Edition, is divided into four progressive sections. The text starts with big-picture information on fitness assessment, beginning with the general fitness levels of the entire nation and then focusing on how fit law enforcement officers compare to the general population. Part II explains the importance of physical fitness and how to train in each of those specific areas to increase cardiorespiratory endurance, muscular strength and endurance, explosive strength, flexibility, agility, speed, and anaerobic power. Part III focuses on lifestyle components of fitness, including diet and nutrition, weight management, stress management, smoking cessation, and the prevention of substance abuse. Part IV ties together all information from the previous sections into achievable plans and goals. It also explains how to avoid common hurdles and pitfalls of adopting lifestyle changes so that officers will have positive results. Throughout the text, exercise drills are featured in a numbered, step-by-step format so that people of all fitness levels can easily follow them. With this text, law enforcement instructors and administrators can establish complete and customized fitness programs that prepare current and future officers in every branch of service. Individual officers will receive the tools they need to improve their fitness levels, which will help them in many situations they might encounter.