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Human epilepsy is a major public health problem affecting
approximately 2 persons per 1000. It is particularly frequent in
ohildren where convul sions may lead to brain damage and subsequent
seizure activity in adulthood. Temporal lobe epilepsy (synonyms
include limbic epilepsy. psychomotor epilepsy and complex partial
epilepsy) is the most devastating form of epilepsy in the adult
population since: a) it is often extremely resistant to currently
available anticonvulsant drugs (i.e ** it is more resistant than
tonico-clonic or grand mal seizures) and b) it includes loss of
consciousness. thereby limiting performance of many normal
functions and leaving the individual susceptible to bodily injury.
It is also associated with nerve cell loss. in particular in the
hippocampus and other structures of the temporal lobes. In order to
promote an appropriate therapy it is essential to understand the
etiology of seizures and its relationship to brain damage. Basic
research on epilepsy also provides a very useful vehicle to learn
about the way the brain functions under normal conditions. For
instance. much of our present understanding of the mechanisms of
action of GABA and benzo diazepines. control of neuronal activity.
etc. has been derived from such stUdies.
The 6th triennial meeting of the International Study Group for
Tryp- tophan Research (ISTRY) was held May 9-12, 1989 in Baltimore,
Maryland (USA). From the wide variety of topics and disciplines
represented, as documented in this volume, it is clear that
tryptophan research and ISTRY are alive and well. ISTRY traces its
or1g1ns to at a tryptophan symposium organized in 1971 by H.
Schievelbein at Hohenried near Munich (Germany). Up to that time
there had been occasional international tryptophan conferences at
irregular inter- vals. A number of participants at the Hohenried
meeting felt that an inter- national tryptophan organization should
be formed to organize regular meet- ings and to foster
collaboration and information exchange on tryptophan-re- lated
topics. Thanks mainly to the founding work of H. Schievelbein and
W. Kochen, an executive committee was elected and ISTRY was born.
The inaugural meeting in 1974 was held in Padova (Italy) to honor
L. Musajo, one of the foremost pioneers in tryptophan studies. This
first ISTRY meeting was suc- cessfully organized by L. Musajo, G.
Allegri, A. De Antoni, and C. Costa, and was critical in assuring
the viability of the new organization. Subsequent meetings were
held in 1977 in Madison, Wisconsin (USA), organized by R.R. Brown,
D.P. Rose, and W.E. Knox, honoring C.P. Berg; 1980 in Kyoto
(Japan), organized by O. Hayaishi, R. Kido, Y. Ishimura, T.
Deguchi, T. Hino, T.
Neuropsychopharmacology: A Tribute to Joseph T. Coyle is a new
volume from Advances in Pharmacology presenting reviews of recent
breakthroughs in glutamate pharmacology and a tribute to one of the
most influential neuroscientists of our times. With a variety of
chapters and the best authors in the field, the volume is an
essential resource for pharmacologists, immunologists, and
biochemists alike.
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