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Comprehensive resource summarizing opportunities and latest
progress in design methodologies for carbohydrate-based
therapeutics through a disease-oriented approach Carbohydrate-Based
Therapeutics covers current progress and explores new frontiers in
carbohydrate-based therapeutic applications, utilizing a unique
approach by providing a detailed background of diseases coupled
with subsequent carbohydrate-based therapies. The link between
chemistry and design of novel carbohydrate-based medicines is
highlighted and a broad overview of all the potential applications
of carbohydrates is given. Emphasis is laid on concepts used for
carbohydrate drug design, structure-activity relationship, and
impact on health and diseases. The text also discusses newer topics
like nanoparticles, material science, and tissue generation.
Carbohydrate-Based Therapeutics includes information on:
Antimicrobial carbohydrate-based therapies, covering antibacterial
and antiviral vaccines, antifungal therapies, anti influenza
therapeutics, and antiadhesive carbohydrates and glycomimetics
Anti-cancer carbohydrate-based therapies, covering cancer vaccines
and immunotherapy, carbohydrate tools in cancer biology, and
carbohydrates and glycoconjugates in autophagy Carbohydrate-based
therapies in metabolic, neuronal, and immune disorders, covering
carbohydrate-based therapeutics for lysosomal disorders and
neurodegenerative diseases New frontiers in carbohydrate-based
therapies, covering carbohydrates for tissue engineering,
antiangiogenic and regenerative medicine, and bowel diseases
Providing comprehensive coverage of foundational knowledge on the
subject in a unique and highly accessible format while also
exploring the state of the art in the field’s applications,
Carbohydrate-Based Therapeutics is an essential resource for
medicinal, pharmaceutical, and organic chemists, chemists in
industry, biochemists, and biotechnologists.
Carbohydrate chemistry provides access to carbohydrate-based
natural products and synthetic molecules as useful biologically
active structures relevant to many health care and disease-related
biological processes. Recent Trends in Carbohydrate Chemistry:
Synthesis, Structure, and Function of Carbohydrates covers green
and sustainable reactions, organometallic carbohydrate chemistry,
synthesis of glycomimetics, multicomponent reactions, and chemical
transformations leading to molecular diversity based on
carbohydrates. These include inhibitors of glycogen phosphorylase,
which are relevant in controlling type 2 diabetes and sugar
sulfates. Polysaccharides, which are commonly modified chemically,
are also examined with contributions covering polysaccharide
synthesis and modification of polysaccharides to obtain new
structures and properties. Recent Trends in Carbohydrate Chemistry:
Synthesis, Structure, and Function of Carbohydrates is ideal for
researchers working as synthetic organic chemists, and for those
interested in biomolecular chemistry, green chemistry,
organometallic chemistry, and material chemistry in academia as
well as in industry
Recent Trends in Carbohydrate Chemistry: Synthesis and Biomedical
Applications of Glycans and Glycoconjugates covers biomedically
relevant bacterial cell wall carbohydrates including recent
findings on biosynthetic aspects, advances in the chemical assembly
of bacterial lipopolysaccharide fragments and teichoic acids, and
modern NMR approaches to unravel structural details. The first part
introduces and provides the relevant background for synthetic
glycoconjugate vaccines. The second section focuses on synthetic
carbohydrate-based vaccines of therapeutic potential that are
licensed or under development. This second volume of Recent Trends
in Carbohydrate Chemistry is ideal for researchers working as
synthetic organic chemists, as well as those interested in
glycoconjugation, protein chemists, immunologists, and
microbiologists, in academia as well as in industry.
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