"The Protective Arm of the RAS: Functional Aspects and Therapeutic Implications" is the first comprehensive publication to signal the protective role of the renin angiotensin system (RAS) providing readers with early insight into a system which will become of major medical importance. It is extensively demonstrated that the RAS, when over activated, represents a disease-promoting and disease-sustaining system. But recently the protective role of the RAS has emerged supported by a large number of experimental studies. In fact, specific components of the RAS, namely angiotensin AT2 receptors (AT2R), the angiotensin (1 7) peptide with its receptor Mas, and the enzyme ACE 2 exert significant beneficial actions by counter-balancing the well-known harmful side of the RAS.
Provides a complete understanding of the protective, beneficial role of the Renin Angiotensin System (RAS).Combines the knowledge of editors who pioneered research on protective renin angiotensin system including Dr. Robson Santos who discovered angiotensins-(1-7) and its receptor Mas; and Dr. U. Muscha Steckelings and Dr. Thomas Unger who made contributions to AT2 receptor research and were the first to use a novel specific AT2-antagonist in preclinical studies.Shows the protective RAS axes are able to ameliorate the course of several cardiovascular, renal and neurological diseases.
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