Readers have access to legions of books dealing with the molecular, genetic, neurochemical, neurophysiological, neuroanatomical, neuroradiological and psychological aspects of pain as well as with the clinical approaches to pain from various medical disciplines. Why then is it necessary to publish a book on the pathophysiologyofpain perception? Pain can result either from noxious events due to lesions, injuries, diseases, etc. , or from disturbances in the system transducing, transforming, and processing the potential pain signal or from an interaction of both. Under certain pathological conditions, the pain-processing system, which includes both physiological and psychological components, can produce the experience of pain in the absence of any peripheral noxious event. This book primarily ex- amines these pathological alterations in the pain-signalling system, and the authors provide information on the functioning of the pain-processing system under normal and pathological conditions. The understanding of pain perception is essential for optimal diagnosis and treatment of acute and chronic pain. Considerable evidence now indicates that alterations in pain per- ception are characteristic of many clinical pain states. Whether disturbed pain perception is a truly etiological or only a maintaining factor-c-or even a mere epiphenomenon of chronic functional pain-is reviewed in detail by L. Arendt-Nielsen, C. R. Covelli, R. B. Fillingim,]. M. Gillespie, T. Graven-Nielsen, E. Kosek, S. Lautenbacher, M. Peters, A. Pielsticker, DO. Price, G. B. Rollman, P. Svensson and G. N. Verne for headache, back pain, fibromyalgia, myofascial pain, temporomandibular pain disorder, irritable bowel syndrome and menstrual cycle-related pain disorders.

Readers have access to legions of books dealing with the molecular, genetic, neurochemical, neurophysiological, neuroanatomical, neuroradiological and psychological aspects of pain as well as with the clinical approaches to pain from various medical disciplines. Why then is it necessary to publish a book on the pathophysiologyofpain perception? Pain can result either from noxious events due to lesions, injuries, diseases, etc. , or from disturbances in the system transducing, transforming, and processing the potential pain signal or from an interaction of both. Under certain pathological conditions, the pain-processing system, which includes both physiological and psychological components, can produce the experience of pain in the absence of any peripheral noxious event. This book primarily ex- amines these pathological alterations in the pain-signalling system, and the authors provide information on the functioning of the pain-processing system under normal and pathological conditions. The understanding of pain perception is essential for optimal diagnosis and treatment of acute and chronic pain. Considerable evidence now indicates that alterations in pain per- ception are characteristic of many clinical pain states. Whether disturbed pain perception is a truly etiological or only a maintaining factor-c-or even a mere epiphenomenon of chronic functional pain-is reviewed in detail by L. Arendt-Nielsen, C. R. Covelli, R. B. Fillingim,]. M. Gillespie, T. Graven-Nielsen, E. Kosek, S. Lautenbacher, M. Peters, A. Pielsticker, DO. Price, G. B. Rollman, P. Svensson and G. N. Verne for headache, back pain, fibromyalgia, myofascial pain, temporomandibular pain disorder, irritable bowel syndrome and menstrual cycle-related pain disorders.

As recently detailed in an Institute of Medicine Report, pain represents one of the most costly and prevalent public health conditions in the United States, and the burden of pain is substantially greater for women than men. Women make up half of the world's population. Yet, the overall treatment of pain in women remains challenging to this day. The differences between men and women are anatomical, physiological and psychosocial in nature. Consequently, several unique features come to mind when discussing pain as experienced by women, such as pain related to pregnancy, pain related specifically to female organs, and chronic painful conditions which have a higher prevalence in the female population. The purpose of this book is to address the current understanding of mechanisms related to sex differences, and the clinical management of common acute and chronic painful conditions in women, using up-to-date evidence-based information. The painful conditions discussed include those that are specific to female anatomy and physiology and conditions that have a higher female prevalence. The book is divided into three sections. The first section covers basic science topics related to sex differences in pain. The epidemiology of painful conditions with female prevalence; sex differences in response to pain, and to analgesics; the role of sex hormones and genotype in pain perception and analgesia; sex differences in cerebral responses to pain revealed by brain imaging ; and the role of psychosocial factors, including psychological interventions will be discussed in this section. The second and third sections are clinically directed. The second section focuses on pain specific to female patients. Topics include the management of labor pain; the management of painful conditions during pregnancy; and the management of pain in the opioid tolerant pregnant patient. The latter includes discussion on the impact of pain management on the fetus in utero, and on the newborn who is breastfed. Chronic pain specific to females, including dysmenorrhea, chronic pelvic pain and vulvodynia will be discussed in this section. Cancer-related pain issues in women will be addressed in the chapter on persistent pain after breast cancer treatment and the chapter on interventional management of pelvic cancer pain. The third section covers painful conditions with high female prevalence. These include fibromyalgia, chronic fatigue syndrome and neuropathic pain in complex regional pain syndrome. Visceral pain with female prevalence such as irritable bowel syndrome, chronic pelvic pain of undetermined etiology will also be addressed in this section. This section also includes chapters on the presentation of cardiac pain in women; headaches including migraine; and temporomandibular joint disorders and orofacial pain. The book is intended for a wide readership, including physicians and allied healthcare professionals who encounter female patients with acute or chronic painful conditions. In addition, residents and medical students in training as well as graduate students in health sciences will benefit greatly from this book as they continue to learn about and manage difficult and complex issues related to pain in female patients.