Readers have access to legions of books dealing with the molecular,
genetic, neurochemical, neurophysiological, neuroanatomical,
neuroradiological and psychological aspects of pain as well as with
the clinical approaches to pain from various medical disciplines.
Why then is it necessary to publish a book on the
pathophysiologyofpain perception? Pain can result either from
noxious events due to lesions, injuries, diseases, etc. , or from
disturbances in the system transducing, transforming, and
processing the potential pain signal or from an interaction of
both. Under certain pathological conditions, the pain-processing
system, which includes both physiological and psychological
components, can produce the experience of pain in the absence of
any peripheral noxious event. This book primarily ex- amines these
pathological alterations in the pain-signalling system, and the
authors provide information on the functioning of the
pain-processing system under normal and pathological conditions.
The understanding of pain perception is essential for optimal
diagnosis and treatment of acute and chronic pain. Considerable
evidence now indicates that alterations in pain per- ception are
characteristic of many clinical pain states. Whether disturbed pain
perception is a truly etiological or only a maintaining factor-c-or
even a mere epiphenomenon of chronic functional pain-is reviewed in
detail by L. Arendt-Nielsen, C. R. Covelli, R. B. Fillingim,]. M.
Gillespie, T. Graven-Nielsen, E. Kosek, S. Lautenbacher, M. Peters,
A. Pielsticker, DO. Price, G. B. Rollman, P. Svensson and G. N.
Verne for headache, back pain, fibromyalgia, myofascial pain,
temporomandibular pain disorder, irritable bowel syndrome and
menstrual cycle-related pain disorders.
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