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Vitamin D deficiency is a worldwide problem linked to numerous
diseases affecting men, women, and children of all ages. Enormous
progress in the study of vitamin D has been made since the first
edition of this highly-acclaimed book was published nearly 20 years
ago, and current research continues to draw headlines. Feldman and
Pike’s Vitamin D, Fifth Edition continues to build on the
successful formula from previous editions, taking the reader from
the basic elements of fundamental research to the most
sophisticated concepts in therapeutics. The two comprehensive
volumes provide investigators, clinicians, and students with a
comprehensive, definitive, and up-to-date compendium of the diverse
scientific and clinical aspects of vitamin D, where each area is
covered by both basic and clinical experts in the field. In Volume
I: Biochemistry, Physiology and Diagnostics, international experts
in endocrinology, bone biology, and human physiology take readers
through the basic research of vitamin D. This impressive reference
presents a comprehensive review of the multi-faceted actions of
vitamin D relating both to skeletal and extra-skeletal action.
Researchers from all areas of vitamin D will gain insight into how
clinical observations and practices can feed back into the research
cycle and will, therefore, be able to develop more targeted genomic
and proteomic insights into the mechanisms of disease. Volume II:
Health, Disease and Therapy authoritatively covers the evidence for
new roles of vitamin D, ranging from organ transplantation to
cancer, diabetes, inflammatory bowel disease, multiple sclerosis,
and renal disease. The coverage is appropriately broad, drawing on
aspects of internal medicine, pediatrics, nutrition, orthopedics,
oncology, neurology, obstetrics and gynecology, and immunology, as
well as, new areas for vitamin D including sports medicine,
opthalmology, veterinary medicine and ICU care – including
COVID-19. Clinical researchers will gain a strong understanding of
the molecular basis for a particular disease and better understand
future directions for research in this still-growing field.
Vitamin D deficiency is a worldwide problem linked to numerous
diseases affecting men, women, and children of all ages. Enormous
progress in the study of vitamin D has been made since the first
edition of this highly-acclaimed book was published nearly 20 years
ago, and current research continues to draw headlines. Feldman and
Pike’s Vitamin D, Fifth Edition continues to build on the
successful formula from previous editions, taking the reader from
the basic elements of fundamental research to the most
sophisticated concepts in therapeutics. The two comprehensive
volumes provide investigators, clinicians, and students with a
comprehensive, definitive, and up-to-date compendium of the diverse
scientific and clinical aspects of vitamin D, where each area is
covered by both basic and clinical experts in the field. In Volume
I: Biochemistry, Physiology and Diagnostics, international experts
in endocrinology, bone biology, and human physiology take readers
through the basic research of vitamin D. This impressive reference
presents a comprehensive review of the multi-faceted actions of
vitamin D relating both to skeletal and extra-skeletal action.
Researchers from all areas of vitamin D will gain insight into how
clinical observations and practices can feed back into the research
cycle and will, therefore, be able to develop more targeted
genomic, proteomic and metabolomic insights into the mechanisms of
disease. Volume II: Health, Disease and Therapy authoritatively
covers the evidence for new roles of vitamin D, ranging from organ
transplantation to cancer, diabetes, inflammatory bowel disease,
multiple sclerosis, and renal disease. The coverage is
appropriately broad, drawing on aspects of internal medicine,
pediatrics, nutrition, orthopedics, oncology, neurology, obstetrics
and gynecology, and immunology, as well as, new areas for vitamin D
including liver metabolism, veterinary medicine and ICU care –
including COVID-19. Clinical researchers will gain a strong
understanding of the molecular basis for a particular disease and
better understand future directions for research in this
still-growing field.
Calcium metabolism is regulated by three specific hormones:
parathor- mone, calciferol metabolites, and calcitonin. Cyclic AMP
also plays an important part in calcium regulation, and its
concentration in urine can be taken as a measure of parathyroid
function. Methods for quantitative measurement of, e.g.
calcium-regulating hormones and vitamin D metabolites as well as of
cAMP are absolutely necessary for safe differential diagnosis of
diseases of the parathyroid like hypo- and hyperparathyroidism. In
this monograph all presently available methods are summarized as to
whether they can already be obtained as test kits or are still
being tested. Radioimmunoassays for the various peptide fragments
such as 53-84, 44-68, 28-48, and 1-34 are described, as are
immunochemiluminescence methods and adenylate cyclase bioassays.
The same is true for the vitamin D metabolites, where the various
assays for calcidiol and calcitriol such as HPLC, protein-binding
assay with second antibody separation, and double antibody RIA are
dex scribed. Finally, determination of calcitonin and cAMP is
discussed in detail. This is a practically and clinically oriented
monograph for working in the fields of internal medicine,
endocrinology, and laboratory medicine.
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Vitamin D - A Pluripotent Steroid Hormone: Structural Studies, Molecular Endocrinology and Clinical Applications. Proceedings of the Ninth Workshop on Vitamin D, Orlando, Florida, USA, May 28-June 2, 1994 (Hardcover, Reprint 2020)
Anthony W. Norman, Roger Bouillon, Monique Thomasset
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Discovery Miles 121 130
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Ships in 10 - 15 working days
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