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Calcium Regulating Hormones, Vitamin D Metabolites, and Cyclic AMP Assays and Their Clinical Application (Paperback, Softcover reprint of the original 1st ed. 1990)
Loot Price: R2,887
Discovery Miles 28 870
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Calcium Regulating Hormones, Vitamin D Metabolites, and Cyclic AMP Assays and Their Clinical Application (Paperback, Softcover reprint of the original 1st ed. 1990)
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Calcium metabolism is regulated by three specific hormones:
parathor- mone, calciferol metabolites, and calcitonin. Cyclic AMP
also plays an important part in calcium regulation, and its
concentration in urine can be taken as a measure of parathyroid
function. Methods for quantitative measurement of, e.g.
calcium-regulating hormones and vitamin D metabolites as well as of
cAMP are absolutely necessary for safe differential diagnosis of
diseases of the parathyroid like hypo- and hyperparathyroidism. In
this monograph all presently available methods are summarized as to
whether they can already be obtained as test kits or are still
being tested. Radioimmunoassays for the various peptide fragments
such as 53-84, 44-68, 28-48, and 1-34 are described, as are
immunochemiluminescence methods and adenylate cyclase bioassays.
The same is true for the vitamin D metabolites, where the various
assays for calcidiol and calcitriol such as HPLC, protein-binding
assay with second antibody separation, and double antibody RIA are
dex scribed. Finally, determination of calcitonin and cAMP is
discussed in detail. This is a practically and clinically oriented
monograph for working in the fields of internal medicine,
endocrinology, and laboratory medicine.
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