Mucoadhesive drug delivery system is now-a-days a booming field for research interest. In the present study an anti-fungal and anti-inflammatory drug are formulated in combination to treat oral candidiasis. This research thus will open a new horizon for fellow researchers to explore buccal route for local targeting of drugs going apart from its conventional use of enhancing the bio availability of poorly absorbed drugs through G.I.Tract. The diverse conditions like Herpes infections, Oral lesions and many more local conditions can be treated efficiently by such formulations. Miconazole Nitrate molecule has been extensively studied and worked upon, which resulted into several formulations and had been brought into the market in various countries. The formulated combination thus is a step ahead treatment for the oral candidiasis, which will show its anti-fungal activity and will also take care of the local inflammation caused due to infection.