Description
Using chips composed of thousands of spots, each with the capability of holding DNA molecules corresponding to a given gene, DNA microarray technology has enabled researchers to measure simultaneously gene expression across the genome. As with other large scale genomics approaches, microarray technologies are broadly applicable across disciplines of life and biomedical sciences, but remain daunting to many researchers. This guide is designed to demystify the technology and inform more biologists about this critically important experimental technique.
.Provides a basic overview of microarray technology and available platforms for those unfamiliar with the technology
.Includes detailed discussion of experimental design and analysis of microarray experiments, giving first-time users valuable information that can be tailored to their own research needs
.Provides discussion of such hot areas as ChIP (chromatin immunoprecipitation) with hybridization to DNA arrays, microarray-based comparative genomic hybridization (CGH), and cell and tissue arrays
Expert author team highlights the utility of the technology using examples from human health and disease--e.g., malaria and cancer diagnostics.