Polypharmacy practices are very common in psychiatry specially in Bangladesh.Psychiatric patients receive multiple drugs in order to have their therapeutic recovery. Both typical and atypical antipsychotic drugs are frequently prescribed by the psychiatrists. Use of multiple antipsychotic molecules may exert some sort of synergistic efficacy but cause a lot of unwanted side effects in the long run. Such a practice can adversely affect the quality of life of the corresponding patients. More rational use of antipsychotic drug should practiced in psychiatry with a view to ensuring quality of life of the psychiatric patients. Atypical antipsychotic drugs are new generation drugs and more safe for use. Besides atypical antipsychotic drugs sometimes offer some unique benefits which make them unparalleled choice.Appropriate drug should be chosen depending on the disease condition and overall benefits of the patients. Unnecessary any molecules' use should be discouraged so that adverse effects or metabolic side effects can be minimized to the least content. In this way we can expect better quality of life along with stabilized psychiatric patients.

The study was designed for phytochemical investigations of ethanolic extract of bark and leaf of Swietenia mahagoni belonging to the family of Meliaceae and evaluation of their biological activities with the special emphasis on analgesic, anti-inflammatory, anti-microbial and cytotoxic screening in different animal model. Phytochemical investigations were done by extensive analysis with high resolution proton NMR spectroscopic data. The ethanol extract of stem bark was partitioned between pet-ether, dichloromethane and methanol fractions. Chromatographic isolation of dichloromethane fraction using column chromatography followed by preparative TLC afforded tetranortriterpenoid compound. Ethanol extract and different fractions showed significant analgesic and anti-inflammatory potential.From the bio-assay of different fractions and extract, significant cytotoxic properties were evaluated whereas mild to moderate antimicrobial activity was found in this study.